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Dive into the research topics where Qingyou Lu is active.

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Featured researches published by Qingyou Lu.


Review of Scientific Instruments | 2009

A simple, compact, and rigid piezoelectric step motor with large step size.

Qi Wang; Qingyou Lu

We present a novel piezoelectric stepper motor featuring high compactness, rigidity, simplicity, and any direction operability. Although tested in room temperature, it is believed to work in low temperatures, owing to its loose operation conditions and large step size. The motor is implemented with a piezoelectric scanner tube that is axially cut into almost two halves and clamp holds a hollow shaft inside at both ends via the spring parts of the shaft. Two driving voltages that singly deform the two halves of the piezotube in one direction and recover simultaneously will move the shaft in the opposite direction, and vice versa.


Review of Scientific Instruments | 2010

Self-manifestation and universal correction of image distortion in scanning tunneling microscopy with spiral scan

J. Wang; Jihui Wang; Yubin Hou; Qingyou Lu

We demonstrate that severe distortions may occur but hard to identify in a standard line-by-line scanned scanning tunneling microscope image, deforming the atomic lattice into a completely different structure type and leading to a wrong interpretation of the data. We also show that a spiral scan image can reveal the details of the drifting by causing the atomic rows to bend with the curvatures being closely related to the extent and direction of the drifting. By straightening the curved atomic rows, the true atomic arrangement can thus be precisely recovered.


Review of Scientific Instruments | 2013

Note: A compact, rigid, and easy-to-build piezo motor: The intact-tube GeckoDrive

Qi Wang; Yubin Hou; Qingyou Lu

We report an extremely simple, rigid, low machine tolerance, yet high performance piezoelectric motor, in which two rings are coaxially glued at the ends of one intact piezotube, respectively, using the proper gluing method. A central shaft is pushed to press against the inner edges of the rings by a spring strip at a proper axial position and in the gap between the shaft and the inner wall of the piezotube. It is compared with other important forms of three-friction driven motors and shows advantageous structure and unexpectedly excellent performance, hence deserving a new name: the GeckoDrive.


Review of Scientific Instruments | 2013

A high-stability scanning tunneling microscope achieved by an isolated tiny scanner with low voltage imaging capability

Qi Wang; Yubin Hou; J. Wang; Qingyou Lu

We present a novel homebuilt scanning tunneling microscope (STM) with high quality atomic resolution. It is equipped with a small but powerful GeckoDrive piezoelectric motor which drives a miniature and detachable scanning part to implement coarse approach. The scanning part is a tiny piezoelectric tube scanner (industry type: PZT-8, whose d31 coefficient is one of the lowest) housed in a slightly bigger polished sapphire tube, which is riding on and spring clamped against the knife edges of a tungsten slot. The STM so constructed shows low back-lashing and drifting and high repeatability and immunity to external vibrations. These are confirmed by its low imaging voltages, low distortions in the spiral scanned images, and high atomic resolution quality even when the STM is placed on the ground of the fifth floor without any external or internal vibration isolation devices.


Review of Scientific Instruments | 2012

A piezo motor based on a new principle with high output force, rigidity and integrity: The Tuna Drive

Xiaolong Liu; Qingyou Lu

We present a linear piezoelectric motor as simple as one piezoelectric scanner tube (PST) spring-clamping a central shaft at both ends with roughly equal clamping forces. The clamping points are aligned with ±X electrodes at one end and ±Y electrodes at the other end. Thus, the ±X (or ±Y) push-pull motions of the PST can cause the push-pull motions of the clamping points on the shaft (called push-pull rubbing), which reduces the total dynamic friction force at one (or the other) end of the PST. This new piezo motor advances one step by fast push-pull rubbing at one end while slowly retracting the PST followed by fast push-pull rubbing at the other end while slowly elongating the PST. Apart from the obvious advantages of simplicity, rigidity, integrity, etc., we will also show that this motor can produce a large output force, which we believe is because of the huge drop of the clamping friction force when the push-pull rubbing occurs.


Oncotarget | 2016

Moderate and strong static magnetic fields directly affect EGFR kinase domain orientation to inhibit cancer cell proliferation.

Lei Zhang; Jihao Wang; Honglei Wang; Wenchao Wang; Zhiyuan Li; Juanjuan Liu; Xingxing Yang; Xinmiao Ji; Yan Luo; Chen Hu; Yubin Hou; Qianqian He; Jun Fang; Junfeng Wang; Qingsong Liu; Guohui Li; Qingyou Lu; Xin Zhang

Static magnetic fields (SMFs) can affect cell proliferation in a cell-type and intensity-dependent way but the mechanism remains unclear. At the same time, although the diamagnetic anisotropy of proteins has been proposed decades ago, the behavior of isolated proteins in magnetic fields has not been directly observed. Here we show that SMFs can affect isolated proteins at the single molecular level in an intensity-dependent manner. We found that Epidermal Growth Factor Receptor (EGFR), a protein that is overexpressed and highly activated in multiple cancers, can be directly inhibited by SMFs. Using Liquid-phase Scanning Tunneling Microscopy (STM) to examine pure EGFR kinase domain proteins at the single molecule level in solution, we observed orientation changes of these proteins in response to SMFs. This may interrupt inter-molecular interactions between EGFR monomers, which are critical for their activation. In molecular dynamics (MD) simulations, 1-9T SMFs caused increased probability of EGFR in parallel with the magnetic field direction in an intensity-dependent manner. A superconducting ultrastrong 9T magnet reduced proliferation of CHO-EGFR cells (Chinese Hamster Ovary cells with EGFR overexpression) and EGFR-expressing cancer cell lines by ~35%, but minimally affected CHO cells. We predict that similar effects of magnetic fields can also be applied to some other proteins such as ion channels. Our paper will help clarify some dilemmas in this field and encourage further investigations in order to achieve a better understanding of the biological effects of SMFs.


Ultramicroscopy | 2014

A compact high field magnetic force microscope

Haibiao Zhou; Ze Wang; Yubin Hou; Qingyou Lu

We present the design and performance of a simple and compact magnetic force microscope (MFM), whose tip-sample coarse approach is implemented by the piezoelectric tube scanner (PTS) itself. In brief, a square rod shaft is axially spring-clamped on the inner wall of a metal tube which is glued inside the free end of the PTS. The shaft can thus be driven by the PTS to realize image scan and inertial stepping coarse approach. To enhance the inertial force, each of the four outer electrodes of the PTS is driven by an independent port of the controller. The MFM scan head is so compact that it can easily fit into the 52mm low temperature bore of a 20T superconducting magnet. The performance of the MFM is demonstrated by imaging a manganite thin film at low temperature and in magnetic fields up to 15T.


Nature Communications | 2015

Evolution and control of the phase competition morphology in a manganite film

Haibiao Zhou; Lingfei Wang; Yubin Hou; Zhen Huang; Qingyou Lu; Wenbin Wu

The competition among different phases in perovskite manganites is pronounced since their energies are very close under the interplay of charge, spin, orbital and lattice degrees of freedom. To reveal the roles of underlying interactions, many efforts have been devoted towards directly imaging phase transitions at microscopic scales. Here we show images of the charge-ordered insulator (COI) phase transition from a pure ferromagnetic metal with reducing field or increasing temperature in a strained phase-separated manganite film, using a home-built magnetic force microscope. Compared with the COI melting transition, this reverse transition is sharp, cooperative and martensitic-like with astonishingly unique yet diverse morphologies. The COI domains show variable-dimensional growth at different temperatures and their distribution can illustrate the delicate balance of the underlying interactions in manganites. Our findings also display how phase domain engineering is possible and how the phase competition can be tuned in a controllable manner.


Review of Scientific Instruments | 2012

18/20 T high magnetic field scanning tunneling microscope with fully low voltage operability, high current resolution, and large scale searching ability

Quanfeng Li; Qi Wang; Yubin Hou; Qingyou Lu

We present a home-built 18/20 T high magnetic field scanning tunneling microscope (STM) featuring fully low voltage (lower than ±15 V) operability in low temperatures, large scale searching ability, and 20 fA high current resolution (measured by using a 100 GOhm dummy resistor to replace the tip-sample junction) with a bandwidth of 3.03 kHz. To accomplish low voltage operation which is important in achieving high precision, low noise, and low interference with the strong magnetic field, the coarse approach is implemented with an inertial slider driven by the lateral bending of a piezoelectric scanner tube (PST) whose inner electrode is axially split into two for enhanced bending per volt. The PST can also drive the same sliding piece to inertial slide in the other bending direction (along the sample surface) of the PST, which realizes the large area searching ability. The STM head is housed in a three segment tubular chamber, which is detachable near the STM head for the convenience of sample and tip changes. Atomic resolution images of a graphite sample taken under 17.6 T and 18.0001 T are presented to show its performance.


Measurement Science and Technology | 2009

Fully low voltage and large area searching scanning tunneling microscope

Zongqiang Pang; Jihui Wang; Qingyou Lu

We present a novel scanning tunneling microscope (STM), which allows the tip to travel a large distance (millimeters) on the sample and take images (to find microscopic targets) anywhere it reaches without losing atomic resolution. This broad range searching capability, together with the coarse approach and scan motion, is all done with only one single piezoelectric tube scanner as well as with only low voltages (<15 V). Simple structure, low interference and high precision are thus achieved. To this end, a pillar and a tube scanner are mounted in parallel on a base with one ball glued on the pillar top and two balls glued on the scanner top. These three balls form a narrow triangle, which supports a triangular slider piece. By inertial stepping, the scanner can move the slider toward the pillar (coarse approach) or rotate the slider about the pillar (travel along sample surface). Since all the stepping motions are driven by the scanners lateral bending which is large per unit voltage, high voltages are unnecessary. The technology is also applicable to scanning force microscopes (SFM) such as atomic force microscopes (AFM), etc.

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Yubin Hou

University of Science and Technology of China

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Jihao Wang

University of Science and Technology of China

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Jihui Wang

University of Science and Technology of China

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Qiyuan Feng

University of Science and Technology of China

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Wenjie Meng

University of Science and Technology of China

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Haibiao Zhou

University of Science and Technology of China

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J. Wang

University of Science and Technology of China

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Qi Wang

University of Science and Technology of China

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Ze Wang

University of Science and Technology of China

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Xin Zhang

Chinese Academy of Sciences

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