Qiong Hu
Anhui Normal University
Network
Latest external collaboration on country level. Dive into details by clicking on the dots.
Publication
Featured researches published by Qiong Hu.
Chemistry-an Asian Journal | 2010
Yimin Hu; Yuan Qu; Feng‐Hua Wu; Jinghan Gui; Yun Wei; Qiong Hu; Shaowu Wang
An efficient domino cyclization method for the construction of aza-podophyllotoxin/aza-conidendrin derivatives has been established. Reactions of different dienes with aryl halides in the presence of a palladium catalytic system produced different kinds of podophyllotoxin derivatives through a highly regioselective C-H functionalization. Treatment of dienes with aryl halides that have electron-withdrawing substituents on the phenyl ring created aza-podophyllotoxin derivatives by means of the functionalization of the C-H bonds ortho to the C-halide bonds of the incoming aryl halides. The reaction of dienes with 1-iodobenzene or aryl halides that incorporate electron-donating groups produced aza-conidendrin derivatives by means of the functionalization of both sp(3) C-H and sp(2) C-H bonds. The regioselective C-H functionalization for the formation of different pseudo-podophyllotoxin/-conidendrin derivatives is proven by analyses of the (1)H NMR spectra of the products and selective X-ray analyses of the structures of the products. Thus, the palladium-catalyzed domino cyclization of 1,6-dienes for the preparation of aza-podophyllotoxin/aza-conidendrin derivatives can be controlled by selectively controlling the C-H functionalization.
Chemistry: A European Journal | 2017
Yimin Hu; Yadong Hu; Qiong Hu; Jie Ma; Shuang Lv; Baohua Liu; Shaowu Wang
A facile method for the synthesis of fused, multifunctionalized salicylaldehydes and salicylketones by a one-pot, three-step cascade hexadehydro-Diels-Alder (HDDA) reaction of tetraynes followed by an intermolecular aldehyde/ketone reaction and hydroxylation is reported. Target compounds were prepared by the condensation of malonates with 3-bromo-1-propyne, and the resulting 2,2-di(1-propyn-3-yl)malonates underwent cross-coupling with phenylethynyl bromides to afford 2,2-di(5-phenyl-2,4-pentadiynyl)malonates, which underwent intramolecular cyclization to produce bicyclic salicylaldehydes. The overall transformation involves the formation of four new C-C bonds and one new Caryl -O bond through both intramolecular and intermolecular reactions. The reaction is easy to perform, proceeds under mild conditions, and exhibits excellent regioselectivity. Water, a simple and readily available reagent, was employed as the OH source. A plausible reaction mechanism is proposed for this new annulation based on isotopic substitution experiments.
Chemistry: A European Journal | 2017
Yimin Hu; Xiangzhen Meng; Shuang Lv; Dong Cheng; Qiong Hu; Jie Ma
The synthesis of fused, highly substituted chromenes in a one-pot-three-step cascade hexadehydro-Diels-Alder reaction of tetraynes followed by an intermolecular α,β-unsaturated aldehyde rearrangement is reported. The target compounds were prepared by the condensation of malonates with 3-bromo-1-propyne, and the resulting 2,2-di(1-propyn-3-yl)malonates underwent cross-coupling with phenylethynyl bromides to afford 2,2-di(5-phenyl-2,4-pentadiynyl)malonates, which underwent intramolecular cyclization to produce tricyclic chromenes. The overall transformation involves the formation of four new C-C bonds and one new C-aryl-O-C-aryl bond by both intramolecular cyclization and intermolecular rearrangement reactions. These constitute a key strategy for the construction of a highly substituted natural chromene core and a robust method for producing other chromenes.
RSC Advances | 2017
Qiong Hu; Lidong Li; Fei Yin; Hao Zhang; Yadong Hu; Baohua Liu; Yimin Hu
The facile synthesis of fused multifunctionalized isoindole-1,3-diones by a hexadehydro-Diels–Alder domino reaction of various substituted tetraynes and imidazole derivatives is reported. The overall transformation involved the formation of three new C–C bonds and two new Caryl–O bonds via intramolecular cyclization and intermolecular coupling oxidation reactions.
Chemical Communications | 2014
Hao Zhang; Qiong Hu; Lidong Li; Yimin Hu; Pingping Zhou; Xiaorong Zhang; Haifeng Xie; Fei Yin; Yadong Hu; Shaowu Wang
Chemical Communications | 2017
Yimin Hu; Jie Ma; Lidong Li; Qiong Hu; Shuang Lv; Baohua Liu; Shaowu Wang
Organic and Biomolecular Chemistry | 2014
Lidong Li; Qiong Hu; Pingping Zhou; Haifeng Xie; Xiaorong Zhang; Hao Zhang; Yadong Hu; Fei Yin; Yimin Hu
Archive | 2017
Yimin Hu; Jie Ma; Lidong Li; Qiong Hu; Shuang Lv; Baohua Liu; Shaowu Wang
Archive | 2017
Yimin Hu; Jie Ma; Lidong Li; Qiong Hu; Shuang Lv; Baohua Liu; Shaowu Wang
Archive | 2017
Yimin Hu; Jie Ma; Lidong Li; Qiong Hu; Shuang Lv; Baohua Liu; Shaowu Wang