Qiong Su

Efficient One-Pot Preparation of Methylthio Arylbutadiynes by Double Elimination Protocol

Abstract A novel and efficient method for preparation of methylthio arylbutadiynes (Ar-C≡C-C≡C-SCH3) was described, and a series of compounds have been expediently obtained by the one-pot protocol starting from methylthiomethyl phenyl sulfone (MP-S) and arylpropargyl aldehydes. The mechanism was discussed on the basis of trapping and characterization of key intermediates. The results from experiments indicated that the reaction involved the initial nucleophilic addition of MP-S to arylpropargyl aldehydes to produce an intermediate carrying two leaving groups and subsequent double elimination reactions. Supplemental materials are available for this article. Go to the publishers online edition of Synthetic Communications® to view the free supplemental file. GRAPHICAL ABSTRACT

Selective Tandem Inter/intramolecular Eglington Coupling for Chiral Cyclophyne Synthesis

Abstract Tandem inter- and intramolecular Eglington couplings take place with good selectivity to afford an enantiopure three-dimensional cyclophyne with a large cavity.

Copper-catalyzed Oxidative Alkylation (Methylation) of Phosphonamides and Phosphinamides by Using Dicumyl Perxide

An effective and practical CuI-catalyzed methodology toward N-alkyl or N-methyl phosphonamides and phosphinamides was herein demonstrated. The transformation took place readily under the oxidative conditions, and plenty of N-alkylated (methylated) amides (30 examples) were successfully furnished in high efficiency (up to 92% yields). Dicumyl peroxide was considered to act either as the oxidant for the alkylation reaction or as methyl donator for the methylation protocol.

2,6-Bis(4-meth-oxy-phen-yl)-1,4-dithiine.

The title molecule, C18H16O2S2, reveals crystallographic twofold rotation symmetry (with both S atoms lying on the axis) and one half-molecule defines an asymmetric unit. The dithiine ring is in a boat conformation. The aromatic ring and the C=C bond are nearly coplanar, with small torsion angles of −171.26 (19) and 8.5 (3)°. The two S—C bond lengths [1.7391 (19) and 1.7795 (18) Å] are shorter than single C—S bonds and longer than analogous C=S double bonds, which indicates a certain degree of conjugation between the lone pair on the S atom and π electrons of the C=C bond. The crystal packing only features van der Waals interactions.