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Journal of Biomedical Science | 2010

Effects of taurine on male reproduction in rats of different ages

Jiancheng Yang; Gaofeng Wu; Ying Feng; Qiufeng Lv; Shumei Lin; Jianmin Hu

BackgroundIt has been demonstrated that taurine is one of the most abundant free amino acids in the male reproductive system, and can be biosynthesized by male reproductive organs. But the effect of taurine on male reproduction is poorly understood.MethodsTaurine and β-alanine (taurine transport inhibitor) were offered in water to male rats of different ages. The effects of taurine on reproductive hormones, testis marker enzymes, antioxidative ability and sperm quality were investigated.ResultsThe levels of T and LH were obviously increased by taurine supplementation in rats of different ages, and the level of E was also significantly elevated in baby rats. The levels of SOD, ACP, SDH and NOS were obviously increased by taurine administration in adult rats, but the levels of AKP, AST, ALT and NO were significantly decreased. The levels of SOD, ACP, LDH, SDH, NOS, NO and GSH were significantly elevated by taurine administration in aged rats, but the levels of AST and ALT were significantly decreased. The motility of spermatozoa was obviously increased by taurine supplement in adult rats. The numbers and motility of spermatozoa, the rate of live spermatozoa were significantly increased by taurine supplement in aged rats.ConclusionsThe present study demonstrated that a taurine supplement could stimulate the secretion of LH and T, increase the levels of testicular marker enzymes, elevate testicular antioxidation and improve sperm quality. The results imply that taurine plays important roles in male reproduction especially in aged animals.


Advances in Experimental Medicine and Biology | 2009

Antihypertensive Effect of Taurine in Rat

Jianmin Hu; Xingli Xu; Jiancheng Yang; Gaofeng Wu; Changmian Sun; Qiufeng Lv

To investigate the effect of taurine on hypertension, a rat model of hypertension was produced by administering N-nitro-L-arginine methylester (L-NAME) to reduce the levels of the vasodilator, nitric oxide. At the same time that L-NAME was administered, taurine treated animals received either 1% or 2% taurine in the drinking water. As a control, 1% taurine was added to the water without L-NAME administration in order to investigate the effects of taurine on blood pressure of normal rats. The results showed that taurine increased serum levels of nitric oxide and nitric oxide synthase, inhibited the elevation of blood pressure, interfered with the activity of the renin-angiotensin-aldosterone system and minimized the elevation in serum cytokine, endothelin, neuropeptide Y and thromboxane B2. It also reduced oxygen derived free radical generation, upregulated the antioxidant defenses and inhibited the proliferation of vascular smooth muscle cells. These data indicate that taurine benefits hypertensive rats, with 2% taurine mediating greater improvement than 1% taurine.


Journal of Biomedical Science | 2010

Preventive effect of taurine on experimental type II diabetic nephropathy.

Shumei Lin; Jiancheng Yang; Gaofeng Wu; Mei Liu; Xinhong Luan; Qiufeng Lv; He Zhao; Jianmin Hu

BackgroundIt has been verified that taurine has some preventive effects on diabetes and its complications when used alone or together with other drugs, but there are few reports about taurine on the prevention of diabetic nephropathy, the mechanisms of which are still unknown.MethodsTaurine was administered to type II diabetic rats induced by high fat high sugar diet combined with STZ injection. The preventive effect of taurine on diabetic nephropathy was investigated by detecting blood glucose, lipid metabolism, kidney function and glomerular basement membrane metabolism.ResultsTaurine could lower blood glucose, TG, TC, BUN, Scr, NAG, U-PRO, the expression of laminin B1( LBN1) mRNA, and increase HDL-C of diabetic rats.ConclusionsThe results indicated that taurine could prevent the occurrence and development of diabetic nephropathy by decreasing blood glucose, improving lipid metabolism, glomerular basement membrane metabolism, and kidney function.


Advances in Experimental Medicine and Biology | 2013

Effects of Taurine on Myocardial cGMP/cAMP Ratio, Antioxidant Ability, and Ultrastructure in Cardiac Hypertrophy Rats Induced by Isoproterenol

Qunhui Yang; Jiancheng Yang; Gaofeng Wu; Ying Feng; Qiufeng Lv; Shumei Lin; Jianmin Hu

Taurine is the most abundant free amino acid in the human body and accounts for more than 50% of the total amino acid pool in the mammalian heart. To investigate the preventive effects of taurine on cardiac hypertrophy in rats, myocardial injury was established by hypodermic injection of isoprenaline (ISO) (10 mg/kg d) for 7 days. The preventive effects of taurine (100 mg/kg d, 200 mg/kg d, and 300 mg/kg d, i.p) on heart coefficient; ultrastructure of cardiac muscle; the levels of creatine kinase heart isoenzyme (CK-MB), cAMP, and cGMP; and antioxidant ability were investigated. The results showed that taurine could significantly prevent the increase of heart coefficient induced by ISO. Compared with the model group, 100 mg/kg and 200 mg/kg taurine significantly decrease the levels of cAMP and cGMP, while 300 mg/kg taurine could significantly decrease the levels of cAMP in myocardium, and all the three concentrations of taurine could significantly increase the ratio of cGMP/cAMP. The level of serum CK-MB was significantly increased by ISO; 200 mg/kg taurine could significantly decrease it, but 100 mg/kg and 300 mg/kg taurine had no significant effect. As for the antioxidant ability, ISO administration could significantly increase the myocardial level of MDA but had no significant effects on the myocardial levels of SOD, GSH, GSH-Px, and T-AOC. However, taurine administration could significantly decrease the myocardial level of MDA and increase the levels of GSH and T-AOC compared with the model group. The serum levels of SOD, GSH-Px, GSH, and T-AOC were significantly reduced by ISO administration, but the level of MDA showed no significant changes compared with the control group. Taurine administration could significantly increase the serum levels of SOD, GSH-Px, GSH, and T-AOC and decrease the level of MDA compared with the model group. All the results indicated that 200 mg/kg taurine had better effects. The ultrastructure of cardiomyocytes showed that taurine administration could significantly reverse the injury caused by ISO. In conclusion, the present study demonstrated that taurine could inhibit the injury induced by ISO by increasing myocardial negative inotropic effect and antioxidant ability, decreasing the hypertrophic response to isoproterenol and protecting the integrity of -myocardial ultrastructure, decreasing myocardial leak of CK-MB.


Advances in Experimental Medicine and Biology | 2013

Inhibitory effects of taurine on STZ-induced apoptosis of pancreatic islet cells.

Shumei Lin; Jiancheng Yang; Gaofeng Wu; Mei Liu; Qiufeng Lv; Qunhui Yang; Jianmin Hu

The present research aims to investigate the inhibition effect of taurine on the apoptosis of pancreatic islet cells induced by Streptozotocin (STZ). One hundred male Wistar rats weighing 180-200 g were randomly divided into two groups, rats in the experimental were intraperitoneally injected with 2% STZ (50 mg/kg bw, dissolved in 0.1 mmol/L pH 4.2 citrate buffer), rats in the control group were injected with the same volume of citrate buffer. Rats with the fasting blood glucose level higher than 16.7 mmol/L were selected and randomly divided into four groups: Rats in M group were STZ-induced diabetes rats, rats in T1, T2, and T3 groups were intragastrically administered with taurine (dissolved in 0.5% sodium carboxymethyl cellulose as thickening agent) once a day for 4 weeks with the contents of 0.6 g/kg, 1.2 g/kg, and 2.4 g/kg bw, respectively, while rats in group C and M were given the same amount of thickening agent as T2 group. Four weeks later, pancreatic tissues were fixed and processed for paraffin section. The results showed that STZ induced a significant increase in apoptotic rate of pancreatic islet cells, up-regulated the expression of bax and Fas and down-regulated the expression of Bcl-2, which were significantly blocked by taurine (P < 0.05). The results indicated that taurine could significantly restrain apoptosis of pancreatic islet cells induced by STZ.


Advances in Experimental Medicine and Biology | 2013

Taurine and Chinese Traditional Medicine Accelerate Alcohol Metabolism in Mice

Gaofeng Wu; Jiancheng Yang; Shumei Lin; Ying Feng; Qunhui Yang; Qiufeng Lv; Jianmin Hu

Excessive alcohol consumption is dangerous and causes serious damage to health. The main organ capable of alcohol oxidizing is liver which is also the main organ synthesizing taurine, a sulfur-containing β-amino acid, which is the major free intracellular amino acid presenting in many tissues of human and animals and exerting many physiologic and pharmacologic functions. To investigate the effect of taurine and Chinese traditional medicine on alcohol metabolism after acute alcoholic intake, male Kunming mice were administered with 60% alcohol (0.4 ml) intragastrically. Water, taurine, or taurine coadministration with Chinese traditional medicine was intragastrically administered to mice 30 min before or after alcohol intake. The disappearance of body-righting reflex was used to determine the intoxication of mice. Durations between alcohol intake and intoxication (tolerance time), intoxication and recovery (maintenance time) were recorded. The concentration of blood alcohol, levels of hepatic alcohol dehydrogenase (ADH), and acetaldehyde dehydrogenase (ALDH) were detected at 20, 50, 90, 120, and 150 min after alcohol intake. The results showed that taurine administered alone or together with Chinese traditional medicine could both significantly reduce the number of intoxicated mice, postpone the tolerance time, shorten the maintenance time, and could obvisouly decrease blood level of alcohol, increase hepatic levels of ADH and ALDH. The results indicated that taurine administered alone or together with traditional Chinese medicine could significantly accelerate the metabolism of alcohol, reduce the toxicity of alcohol, and coadministration of taurine and traditional Chinese medicine had better effects.


Advances in Experimental Medicine and Biology | 2013

Synergistic effects of taurine and L-arginine on attenuating insulin resistance hypertension.

Ying Feng; Jitao Li; Jiancheng Yang; Qunhui Yang; Qiufeng Lv; Yongchao Gao; Jianmin Hu

To elucidate the synergistic effects of taurine and L-arginine on hypertension, 25% fructose were administered to male Wistar rats for 3 months to establish insulin resistance hypertensive models. Rats with the systolic blood pressure (SBP) higher than 150 mmHg were considered as model rats. Forty-two model rats were randomly divided into six groups and administered with 3% taurine, 2.7% taurine + 0.3% L-arginine, 2.1% taurine + 0.9% L-arginine, 1.5% taurine + 1.5% L-arginine and 3% L-arginine in drinking water respectively. The results showed that coadministration of taurine (1.5%) and L-arginine (1.5%) could bring the levels of SBP, blood glucose, and insulin down to normal levels after 4 weeks. The thickness of blood vessels increased significantly in model group, which could be reversed by taurine and L-arginine. Serum NO, cGMP, and ET levels could return to normal levels. These data indicated that both taurine and L-arginine could ameliorate vascular remodeling and showed obvious antihypertensive effects, and taurine (1.5%) and L-arginine (1.5%) in the drinking water showed a better result in the cure of hypertension.


Advances in Experimental Medicine and Biology | 2015

Effects of Taurine on Blood Index of Hypothalamic Pituitary Adrenal (HPA) Axis of Stress-Induced Hypertensive Rat

Qiufeng Lv; Gonglin Dong; Shuang Cao; Gaofeng Wu; Ying Feng; Liu Mei; Shumei Lin; Qunhui Yang; Jiancheng Yang; Jianmin Hu

To elucidate the protective mechanism of taurine against stress induced hypertension, 32 male Wistar rats were randomly divided into four groups: normal control group; stress control group; β–alanine stress group and taurine stress group. Rats of the two control groups were administered physiological saline while the β–alanine treated group was administered β–alanine (200 mg/kg/day) and the taurine treated group was administered taurine (200 mg/kg/day). The hypertensive model was produced by stressing the rats for 3 weeks. Serum levels of angiotensin converting enzyme (ACE), angiotensin II (AngII), glucocorticoid hormone (CRH), adrenocorticotropic hormone (ACTH), Glucocorticoid (GC), epinephrine (EPI), norepinephrine (NA) in the β–alanine stress group was significantly higher than those of the other groups (P < 0.05). However, serum of the taurine stress group contained more angiotensin converting enzyme 2 (ACE2) than those of the other groups (P < 0.05). These data indicate that taurine regulates the hypothalamus pituitary adrenal (HPA) axis of the renin-angiotensin-aldosterone system (RAAS), thereby contributing to the prevention of stress-induced hypertension.


Archive | 2017

Taurine Recovers Testicular Steroidogenesis and Spermatogenesis in Streptozotocin-Induced Diabetic Rats

Hong Liu; Shumei Lin; Qiufeng Lv; Qunhui Yang; Gaofeng Wu; Jianmin Hu; Jiancheng Yang

A great deal of investigations have verified that diabetic male reproductive impairment is associated with the dysfunction of testicular steroidogenesis and spermatogenesis resulted from insulin deficiency and hyperglycaemia-induced oxidative stress. It has been identified taurine is profitable for diabetes mellitus and diabetic implications through its insulin-like and islet cells protective activity. Furthermore, our previous studies found that taurine could increase testicular antioxidative ability, stimulate the endocrine activity of hypothalamic-pituitary-testicular axis, elevate testosterone level, raise sperm quality, suppress the deterioration of testicular function. Accordingly, we hypothesized that taurine may have beneficial effects on testicular dysfunction under diabetic mellitus status. Here, we investigated the effects of taurine on testicular steroidogenesis and spermatogenesis in streptozotocin (STZ)-induced type I diabetic rats. We observed that taurine treatment can markedly increase the body and testis weights, testicular SDH and G6PDH activities, decrease the serum fasting glucose concentration of diabetic rats. Serum contents of GnRH, LH, FSH, T, and testicular StAR, 3β-HSD, 17β-HSD mRNA expression levels were also obviously raised by taurine administration, indicating that taurine can improve testicular steroidogenesis in diabetic animals. Finally, we found taurine supplementation effectively elevated the sperm count and motility, reduced sperm abnormality, suggesting that taurine can increase the testicular spermatogenesis function of diabetic rat. In summary, the present data indicated that taurine can rescue the function of testicular steroidogenesis and spermatogenesis in STZ-induced type I diabetic rats possibly by increasing the endocrine activity of hypothalamic-pituitary-testicular axis.


Advances in Experimental Medicine and Biology | 2015

Taurine accelerates alcohol and fat metabolism of rats with alcoholic Fatty liver disease.

Gaofeng Wu; Riyi Tang; Jiancheng Yang; Yan Tao; Zhiyuan Liu; Ying Feng; Shumei Lin; Qunhui Yang; Qiufeng Lv; Jianmin Hu

Liver is considered to be the main organ capable of oxidizing alcohol and fat. Chronic consumption of alcohol is the major cause of liver injury and the development of alcoholic fatty liver disease (AFLD). Liver is also the main organ capable of synthesizing taurine, and the effects of taurine on liver disease have aroused great attention. In the present study, alcohol and pyrazole were administered to male Wistar rats by way of intragastric administration and combined with a high fat diet in order to establish the AFLD model. Taurine was administered in the drinking water during and after the establishment of the AFLD model. The preventive experiment lasted for 12 weeks. The curative experiment was divided into 4 and 8 weeks. Hepatic activities of ADH, ALDH, serum ALT, AST, TC, TG, HDL-C, LDL-C, NEFA and hepatic NEFA were measured. The results showed that hepatic ADH and ALDH in AFLD rats were significantly lower while serum ALT, AST, TC, TG, LDL-C, NEFA and hepatic NEFA in model group were significantly higher than normal rats (P < 0.05), and serum HDL-C was obviously lower. Serum ALT, AST, TC, TG, LDL-C, NEFA, and hepatic NEFA were decreased in taurine preventive and curative groups (P < 0.05), while hepatic activities of ADH and ALDH, serum HDL-C were significantly increased in taurine groups (P < 0.05). Observation of the pathological sections showed that taurine can significantly attenuate fatty degeneration and the deposition of the liver caused by alcohol. The results indicated that taurine presumably accelerates the metabolism of alcohol and fat in the liver, thereby inhibiting and reversing hepatic fatty degeneration in AFLD rats.

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Jiancheng Yang

Shenyang Agricultural University

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Jianmin Hu

Shenyang Agricultural University

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Gaofeng Wu

Shenyang Agricultural University

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Qunhui Yang

Shenyang Agricultural University

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Shumei Lin

Shenyang Agricultural University

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Ying Feng

Shenyang Agricultural University

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Mei Liu

Shenyang Agricultural University

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Gonglin Dong

Shenyang Agricultural University

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Shuang Cao

Shenyang Agricultural University

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Yiqing Cui

Shenyang Agricultural University

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