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Dive into the research topics where R A de Melker is active.

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Featured researches published by R A de Melker.


BMJ | 1991

Co-amoxiclav in recurrent acute otitis media: placebo controlled study.

C. L. M. Appelman; J. Q. P. J. Claessen; F. W. M. M. Touw-Otten; G. J. Hordijk; R A de Melker

OBJECTIVE--To determine the efficacy of coamoxiclav in children aged 6 months to 12 years with recurrent acute otitis media. DESIGN--A randomised double blind placebo controlled clinical trial. SETTING--General practice in the Netherlands. PATIENTS--121 children with recurrent acute otitis media, defined by onset of otalgia and otoscopic signs of middle ear infection within four to 52 weeks after the previous attack. Confirmation of diagnosis and randomisation was done by otolaryngologists. INTERVENTION--Oral co-amoxiclav or placebo in weight related doses for seven days. MAIN OUTCOME MEASURE--An irregular clinical course defined as the presence of otalgia or a body temperature greater than or equal to 38 degrees C, or both, after three days. RESULTS--Eleven (16%; 95% confidence interval 9% to 28%) children had an irregular course in the co-amoxiclav group and 10 (19%; 9% to 31%) in the placebo group (difference not significant). Age, dichotomised at 2 years, was the only significant prognostic factor for irregular course of the disease (odds ratio 5.9; 1.8 to 19.1). Among children aged below 2 years, 28% (4/14) in the co-amoxiclav group and 58% (7/12) in the placebo group had irregular courses. For children 2 years and older these percentages were 13% (7/52) and 7% (3/41). CONCLUSION--Children with recurrent acute otitis media are at greater risk of an irregular clinical course of the disease than children with a first episode of acute otitis media. Co-amoxiclav has no significant benefit over placebo in treating children over 2 years with acute otitis media.


Journal of Epidemiology and Community Health | 1998

Is immunising all patients with chronic lung disease in the community against influenza cost effective? Evidence from a general practice based clinical prospective cohort study in Utrecht, the Netherlands

Eelko Hak; G A van Essen; Erik Buskens; W.A.B. Stalman; R A de Melker

STUDY OBJECTIVE: There is little information on the potential benefit of immunising all patients with chronic lung disease in the community against influenza. The clinical effectiveness and economic benefit was established of the influenza vaccination programme in a general practice based cohort of adult patients with chronic lung disease followed up during the 1995/96 influenza A epidemic. DESIGN: A prospective cohort study from October 1995 to March 1996. SETTING: The study was undertaken in the Utrecht General Practices Network with six large group practices, covering a total population of approximately 50,000 patients in the Netherlands. PATIENTS: Computerised medical records of 1696 patients with chronic lung disease aged over 18 years with an indication for vaccination according to the Dutch GP guidelines were reviewed. MAIN RESULTS: The overall attack rate of any complication, including all cause death, low respiratory tract infection, and acute cardiac disease was 15%. Exacerbations of lung disease were most frequent (13%). Death, pneumonia, and acute cardiac disease were mainly limited to patients > or = 65 years. No effectiveness of the immunisation programme could be established in patients 18-64 years (n = 1066), after controlling for baseline prognosis in multivariable logistic regression analysis. In vaccinees > or = 65 years (n = 630), the occurrence of any complication was reduced by 50% (95% CI 17, 70%). The economic benefit was estimated at 50 Pounds per elderly vaccinee. CONCLUSIONS: This study suggests that in the Netherlands immunisation of elderly patients with chronic lung disease against influenza is effective and cost-saving, hence these patients should be given high priority. More, preferably experimental, studies are needed to establish whether adult lung patients under 65 years in the community will also benefit from vaccination.


Medical Education | 1999

Are professional attitudes related to gender and medical specialty

V Batenburg; J. A. Smal; Aart Lodder; R A de Melker

The importance of professional attitudes in medical care has long been recognized; however, medical training has not stressed attitude development until recently. In previous studies among medical students, we found that gender and specialty preference are important factors in attitudes. In this study, patient‐centredness of trainees in general practice and surgery and of final‐year clerks preferring one of these specialties was assessed in one medical school in The Netherlands. The effect of gender, specialty and training level on attitude was investigated.


Gut | 1999

What makes the dyspeptic patient feel ill? A cross sectional survey of functional health status, Helicobacter pylori infection, and psychological distress in dyspeptic patients in general practice

A O Quartero; M W M Post; Mattijs E. Numans; R A de Melker; N.J. de Wit

BACKGROUND Dyspepsia is prevalent in about 30% of the general population in Europe, but only 25% of people with complaints consult their general practitioner. AIMS To study the relation between the severity of dyspeptic complaints and the health status of patients presenting to the general practitioner; and the relation with patient characteristics, Helicobacter pyloriinfection, and psychological distress. METHODS A cross sectional, general practice based survey of 360 unselected primary care dyspeptic patients from 92 general practices in The Netherlands was conducted. Symptom severity was measured using a validated symptom score,H pylori using a whole blood test, and psychological distress using the GHQ-12 test. Functional health status was assessed using the COOP/Wonca charts. RESULTS Symptoms lasting more than three months and presence of relevant psychological distress were both associated with higher levels of dyspepsia.H pylori infection, frequency of symptoms, and age had no influence on dyspepsia severity. Severity of dyspepsia and psychological distress, but not H pyloriinfection or duration of symptoms, affected health status univariately. Dyspepsia correlated with general health, daily activities, and social activities. In logistic modelling, health status was far better predicted by psychological distress than by dyspepsia severity. CONCLUSION The relation between dyspeptic symptom severity and health status is limited.H pylori infection relates neither to functional health status, nor to intensity of dyspepsia. Psychological distress is a major determinant of impaired health of dyspeptic patients in general practice and may be the clue to improvement of health status in many dyspeptic patients.


The Lancet | 1996

Double-blind randomised trial of co-amoxiclav versus placebo for persistent otitis media with effusion in general practice

Fam van Balen; R A de Melker; F. W. M. M. Touw-Otten

BACKGROUND The treatment of persistent otitis media with effusion (OME) remains controversial, but this condition is the commonest reason for children to require ear, nose, and throat (ENT) surgery. Trials of antibiotics are inconclusive, are often weak methodologically, and have not been done in general practice. Our aim was a trial of an antibiotic for OME in such a population. METHODS 433 children, aged 6 months to 6 years, with OME from 57 general practices entered a 3-month watchful waiting period. Of 223 (52%) with persistent bilateral OME, 162 were randomised double-blind to receive co-amoxiclav suspension (20 mg/kg amoxicillin, 5 mg/kg clavulanate potassium) or matching placebo, orally three times a day for 14 days. All cases also received xylometazoline 0.25% decongestant nosedrops thrice daily. Of the 61 not randomised, 13 children were referred to an ENT surgeon and parents refused consent in 48 cases. The main outcome measures were persistent OME in both ears and in one or both ears, as assessed clinically and by tympanometry. Analysis was by intention-to-treat. FINDINGS 79 children in the treatment group and 70 in the placebo group were analysed for efficacy. 3 withdrew in the co-amoxiclav group (2 lost to follow-up, 1 due to side-effects); 6 withdrew in the placebo group (5 and 1, respectively). In addition, 4 tympanograms were uninterpretable in the controls. Compliance was over 90% in both groups. Persistent OME in both ears and in one or both ears were found at significantly lower rates in the co-amoxiclav group than in the controls at the 2-week follow-up: 53 vs 84% and 77 vs 93%, respectively. Odds ratios adjusted for sex, history of adenoidectomy, and upper respiratory tract infection at follow-up were 0.25 (95% CI 0.11, 0.58, p = 0.001) and 0.30 (0.10, 0.89, p = 0.03), respectively. Parents of children in the co-amoxiclav group reported significantly more side-effects than those of control children (44 vs 22%, p = 0.03). Side-effects were mostly gastrointestinal and mild. INTERPRETATION Our study in a general-practice setting confirmed the positive short-term effect of antibiotic treatment for persistent middle-ear infection. Before referral to an ENT surgeon, children with persistent OME presenting to general practitioners could be considered for such treatment, depending on the individual child and possible adverse sequelae.


International Journal of Pediatric Otorhinolaryngology | 1994

Validation of a portable tympanometer for use in primary care

F.A.M. van Balen; R A de Melker

Abstract Objective — to determine the accuracy of a handheld, portable tympanometer, the microtymp, in comparison with a reference instrument, the AR 85 tympanometer and with the gold standard: presence or absence of middle-ear fluid. Design — comparison of results from the microtymp with results from the reference tympanometer, the AR 85 and the gold standard. Setting — University Childrens Hospital, Utrecht and the General Hospital, Overvecht, Utrecht. Subjects — 142 children (284 ears) aged between 6 months and 12 years, who were referred by their General Practitioner or Ear, Nose and Throat surgeon for myringotomy and/or tympanostomy tube insertion. Main outcome measures — tympanometry with the AR 85 and presence or absence of middle-ear fluid. Results — In 243 ears, of the included 284 ears, the test results of the microtymp were compared with those of the reference instrument, the AR 85 tympanometer. Sensitivity 0.96 (95% C.I., 0.93, 0.99), Specificity 0.81 (95% C.I.: 0.71, 0.91). In 233 ears, of the included 284 ears, the test results of the microtymp were compared with the gold standard. Sensitivity 0.94 (95% C.I.: 0.90, 0.98), specificity 0.48 (95% C.I.: 0.37, 0.59). Conclusion — The microtymp is a valid instrument for diagnosing middle-ear effusions. The results of the microtymp are highly comparable with traditional tympanometers: high sensitivity and much lower specificity. Use in primary care can increase diagnostic accuracy of otitis media with effusion (OME) and makes follow-up possible. This will help to discriminate between those OME cases who need further treatment and those who will resolve spontaneously.


BMJ | 1993

Treating persistent glue ear in children.

R A de Melker

view of its clear advantages over the other lasers, whose rate of energy delivery does not match the predicted physical behaviour of the blood vessels, we suggest that the pulsed dye laser should be offered as the first line treatment for portwine stains whenever possible. M J C VAN GEMERT Professor of Laser Medicine Laser Centre, Academic Medical Centre, Amsterdam 1 105AZ, The Netherlands J A S CARRUTH Consultant Otolaryngologist ENT Department, Royal South Hants Hospital, Southampton S09 4PE P G SHAKESPEARE Director Laing Laboratory, Odstock Hospital, Salisbury SP2 8BJ


Scandinavian Journal of Gastroenterology | 2001

Dyspepsia in primary care: Acid suppression as effective as prokinetic therapy. A randomized clinical trial

A O Quartero; Mattijs E. Numans; R A de Melker; Arno W. Hoes; N.J. de Wit

Background: While dyspeptic patients in primary care often receive empirical treatment with antisecretory drugs, a substantial number suffer from motility disturbances which may be associated with their complaints. We aimed to compare the effectiveness of treatment with antisecretory treatment with a prokinetic agent in uninvestigated dyspepsia. Methods: 563 patients presenting dyspeptic complaints to the general practitioner with a low likelihood of organic (ulcer, reflux or malignant) disease, i.e. absence of alarm symptoms or a history of peptic ulcer disease or gastro-oesophageal reflux disease were included. They entered a randomized, double-blind trial of 4 weeks of ranitidine 150 mg bid compared with 4 weeks of cisapride 10 mg bid, with 3 months follow-up. Treatment failure was defined as no response to treatment or a relapse of symptoms within the follow-up period. Also studied were the effect on dyspepsia severity, response to treatment after 4 weeks, and time to relapse. Results: For all randomized patients, the incidence of overall treatment success after 3 months follow-up with antisecretory treatment was 107/271 (39.5%) and with a prokinetic agent 122/282 (43.3%); the risk difference was 3.8% (95% CI-4.4% to 12.0%); the difference in symptom severity score after 4 weeks of treatment was 0.3; 95% CI-0.4% to 1.0%. For patients responding to 4 weeks of treatment, relapsefree time was 86 days in the prokinetic group and 79 days in the acid suppression group (P = 0.005). Conclusions: Antisecretory and prokinetic therapies are equally effective in primary care patients with uninvestigated dyspeptic complaints, though relapse rates are lower in patients treated with prokinetic treatment.BACKGROUND While dyspeptic patients in primary care often receive empirical treatment with antisecretory drugs, a substantial number suffer from motility disturbances which may be associated with their complaints. We aimed to compare the effectiveness of treatment with antisecretory treatment with a prokinetic agent in uninvestigated dyspepsia. METHODS 563 patients presenting dyspeptic complaints to the general practitioner with a low likelihood of organic (ulcer, reflux or malignant) disease, i.e. absence of alarm symptoms or a history of peptic ulcer disease or gastro-oesophageal reflux disease were included. They entered a randomized, double-blind trial of 4 weeks of ranitidine 150 mg bid compared with 4 weeks of cisapride 10 mg bid, with 3 months follow-up. Treatment failure was defined as no response to treatment or a relapse of symptoms within the follow-up period. Also studied were the effect on dyspepsia severity, response to treatment after 4 weeks, and time to relapse. RESULTS For all randomized patients, the incidence of overall treatment success after 3 months follow-up with antisecretory treatment was 107/271 (39.5%) and with a prokinetic agent 122/282 (43.3%); the risk difference was 3.8% (95% CI -4.4% to 12.0%); the difference in symptom severity score after 4 weeks of treatment was 0.3; 95% CI -0.4% to 1.0%. For patients responding to 4 weeks of treatment, relapse-free time was 86 days in the prokinetic group and 79 days in the acid suppression group (P = 0.005). CONCLUSIONS Antisecretory and prokinetic therapies are equally effective in primary care patients with uninvestigated dyspeptic complaints, though relapse rates are lower in patients treated with prokinetic treatment.


British Journal of General Practice | 1997

The end of antibiotic treatment in adults with acute sinusitis-like complaints in general practice? A placebo-controlled double-blind randomized doxycycline trial.

W A B Stalman; G A van Essen; Y. van der Graaf; R A de Melker


British Journal of General Practice | 1996

Do patients with sore throat benefit from penicillin? A randomized double-blind placebo-controlled clinical trial with penicillin V in general practice.

C F Dagnelie; Y. van der Graaf; R A de Melker

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Eelko Hak

University of Groningen

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Mattijs E. Numans

Leiden University Medical Center

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W.A.B. Stalman

VU University Medical Center

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