R. A. Maxwell

Studies with the Ganglionic Blocking Agent, Chlorisondamine Chloride in Unanesthetized and Anesthetized Dogs

The normotensive unanesthetized dog receiving chlorisondamine chloride, pentapyrrolidinium, or hexamethonium exhibits a drop in systolic blood pressure, narrowing of pulse pressure, tachycardia and relaxation of nictitating membranes. The relative potencies of these compounds are in the ratio 8:3:1 respectively. While these compounds are apparently equally well absorbed, the activity of chlorisondamine chloride is markedly prolonged. This prolonged activity of chlorisondamine chloride after oral administration is probably due, in large part, to its persistence in the tissues. Chlorisondamine chloride and hexamethonium can suppress the pressor response induced in neurogenic hypertensive dogs by application of annoying stimuli.

Effects of Reserpine on Urinary Bladder Tension

Summary Reserpine will produce a gradual increase in bladder tension which is initiated within five minutes after intravenous injection. This response is not blocked by ganglionic blocking agents. Atropine has a slight to moderate antagonizing effect on this response. The adrenergic blocking agent, phentolamine, has a marked antagonizing effect on this response. Reserpine can potentiate the response of the bladder to mecholyl and carbamylcholine. The significance of these facts is discussed.

Influence of Adrenergic Blockade and an Amine Oxidase Inhibitor on Reserpine Hypotension

Summary In proper doses administration of reserpine phosphate subsequent to adrenergic blockade with phentolamine will produce a more rapid decline in blood pressure than is commonly obtained by administration of reserpine alone. After pretreatment with amine oxidase inhibitor, choline p-tolyl ether, reserpine will produce pressor responses. These data are interpreted as supporting the hypothesis that reserpine releases sympathomimetic humoral agents which mask the early onset of the cardiovascular actions commonly attributed to reserpine.

Effect of ganglionic blocking agents on pressor responses induced by splanchnic faradization.

Summary The effects of the ganglionic blocking agents, TEA, hexamethonium, pentapyrrolidinium and chlorisondamine chloride on the pressor responses induced by peripheral splanchnic faradization have been determined in 16 cats. These agents did not antagonize the pressor responses when the ipsi-lateral adrenal gland was present or after it had been ablated. The significance of these findings is discussed.

Cardiovascular Response of the Anesthetized Hamster to Reserpine and Ganglionic Blockade

The changes produced by reserpine and the ganglionic blocking agent, chlorisondamine chloride on the blood pressure, peripheral flow and blood vessel caliber of the hamster have been studied in an attempt to determine the first cause of the hypotensive effect of these compounds.