R. Abou Taam

Surfactant protein C gene (SFTPC) mutation-associated lung disease: high-resolution computed tomography (HRCT) findings and its relation to histological analysis.

Determine high‐resolution tomography (HRCT) scan characteristics in children with SFTPC mutation and correlate them to histological findings.

Incidence Rate and Factors Related to Post-Bronchoalveolar Lavage Fever in Children

Background: Post-bronchoscopy and bronchoalveolar lavage (BAL) fever in children has been described by several authors. Objectives: This study aimed at assessing the occurrence of fever after these examinations and associated risk factors. Methods: The study was performed in the Bronchoscopy Unit of Hôpital Necker-Enfants Malades, Paris, France, from June 2004 to July 2005. 148 children who underwent fiberoptic bronchoscopy and BAL, and remained in the Unit for 24 h, were included. Results: 37.8% of the patients presented post-BAL fever. In the multivariate analysis of the selected factors (age, immunodeficiency, general or local anesthesia, mucosal biopsy, inflammation and suppuration at the moment of the examination, abnormal bronchoalveolar fluid cellularity and infection), only age <2 years and presence of infection remained associated with fever. Conclusions: The occurrence of fever is a frequent event in children who underwent BAL. In order to reduce post-BAL fever, antibiotic strategies should be devised based on prospective studies assessing identification of predictive air-way infection criteria and/or rapid bacteriological result analysis.

Remodelling and inflammation in preschoolers with severe recurrent wheeze and asthma outcome at school age

The influence of airway remodelling and inflammation in preschoolers with severe recurrent wheeze on asthma outcomes is poorly understood.