R. El Hage

Geometric indices of hip bone strength in obese, overweight, and normal-weight adolescent boys

SummaryThe aim of this study was to compare hip bone strength indices in obese, overweight, and normal-weight adolescent boys using hip structure analysis. After adjusting for weight, obese boys displayed lower intertrochanteric cross-sectional moment of inertia and femoral shaft cross-sectional moment of inertia and section modulus in comparison to normal-weight and overweight boys. This study suggests that in obese adolescent boys, femoral shaft bending strength is not adapted to the increased body weight.IntroductionThe influence of being obese or overweight on bone strength in adolescents remains controversial. The main aim of this study was to compare hip bone strength indices in obese, overweight, and normal-weight adolescent boys using hip structure analysis. The second aim of this study was to explore the influence of lean mass and fat mass on hip bone strength indices in the same population.MethodsThis study included 70 adolescent boys (25 obese, 25 normal weight, and 20 overweight). The three groups (obese, overweight, and normal weight) were matched for maturity (Tanner stage) and age. Body composition and bone mineral density (BMD) were assessed by dual-energy X-ray absorptiometry (DXA). To evaluate hip bone strength, DXA scans were analyzed at the femoral neck (FN), the intertochanteric (IT), and the femoral shaft (FS) by the Hip Structure Analysis (HSA) program. Cross-sectional area (CSA), an index of axial compression strength, section modulus (Z), an index of bending strength, and cross-sectional moment of inertia (CSMI), an index of structural rigidity were measured from bone mass profiles.ResultsBody weight, lean mass, fat mass and BMI were significantly higher in obese and overweight boys in comparison to normal-weight boys (P < 0.05). Total hip (TH) BMD and femoral neck (FN) BMD were significantly higher in obese and overweight boys in comparison to normal-weight boys (P < 0.05). After adjusting for age or maturation index, obese and overweight boys displayed significantly higher TH and FN BMD, CSA, CSMI, and Z of the three sites (FN, IT, and FS) in comparison to normal-weight boys (P < 0.05). However, after adjusting for weight, obese boys displayed significantly lower IT CSMI and FS CSMI and Z in comparison to normal-weight and overweight boys (P < 0.05).ConclusionsThis study suggests that in obese adolescent boys, intertrochanteric structural rigidity and femoral shaft structural rigidity and bending strength are not adapted to the increased body weight.UNLABELLED The aim of this study was to compare hip bone strength indices in obese, overweight, and normal-weight adolescent boys using hip structure analysis. After adjusting for weight, obese boys displayed lower intertrochanteric cross-sectional moment of inertia and femoral shaft cross-sectional moment of inertia and section modulus in comparison to normal-weight and overweight boys. This study suggests that in obese adolescent boys, femoral shaft bending strength is not adapted to the increased body weight. INTRODUCTION The influence of being obese or overweight on bone strength in adolescents remains controversial. The main aim of this study was to compare hip bone strength indices in obese, overweight, and normal-weight adolescent boys using hip structure analysis. The second aim of this study was to explore the influence of lean mass and fat mass on hip bone strength indices in the same population. METHODS This study included 70 adolescent boys (25 obese, 25 normal weight, and 20 overweight). The three groups (obese, overweight, and normal weight) were matched for maturity (Tanner stage) and age. Body composition and bone mineral density (BMD) were assessed by dual-energy X-ray absorptiometry (DXA). To evaluate hip bone strength, DXA scans were analyzed at the femoral neck (FN), the intertochanteric (IT), and the femoral shaft (FS) by the Hip Structure Analysis (HSA) program. Cross-sectional area (CSA), an index of axial compression strength, section modulus (Z), an index of bending strength, and cross-sectional moment of inertia (CSMI), an index of structural rigidity were measured from bone mass profiles. RESULTS Body weight, lean mass, fat mass and BMI were significantly higher in obese and overweight boys in comparison to normal-weight boys (P < 0.05). Total hip (TH) BMD and femoral neck (FN) BMD were significantly higher in obese and overweight boys in comparison to normal-weight boys (P < 0.05). After adjusting for age or maturation index, obese and overweight boys displayed significantly higher TH and FN BMD, CSA, CSMI, and Z of the three sites (FN, IT, and FS) in comparison to normal-weight boys (P < 0.05). However, after adjusting for weight, obese boys displayed significantly lower IT CSMI and FS CSMI and Z in comparison to normal-weight and overweight boys (P < 0.05). CONCLUSIONS This study suggests that in obese adolescent boys, intertrochanteric structural rigidity and femoral shaft structural rigidity and bending strength are not adapted to the increased body weight.

DXA-based variables and osteoporotic fractures in Lebanese postmenopausal women

INTRODUCTION The aim of this study was to assess DXA-based variables (bone mineral density, bone mineral apparent density, compressive strength index of the femoral neck and trabecular bone score) in Lebanese postmenopausal women having presented a previous fracture. MATERIALS AND METHODS One thousand Lebanese postmenopausal women between 45 and 89 years participated in this study. The women were recruited by advertisements offering bone mineral density measurements at a reduced cost. Subjects with previous history of radiotherapy or chemotherapy were excluded. Informed written consent was obtained from all the participants. RESULTS Femoral neck compressive strength index (FN CSI) was significantly (P<0.001) associated with the presence of fracture using a simple logistic regression (odds ratio=0.51 [0.385-0.653]). When a multivariate logistic regression analysis was performed with the presence of fracture as a dependent variable and each of age, FN BMD and FN CSI as independent variables, only FN BMD (P=0.005) and FN CSI (P=0.004) were found to be associated with the presence of fracture. CONCLUSION This study suggests that FN CSI is associated with history of osteoporotic fractures in postmenopausal women. The use of FN CSI in clinical practice may help to identify patients with high risk of fracture. LEVEL OF EVIDENCE Epidemiological study, level IV.

Epidemiology of hip fractures in Lebanon: A nationwide survey

INTRODUCTION Hip fractures are a reliable indicator of osteoporosis. Despite their importance, few studies have assessed their epidemiology in Lebanon and the Middle East. HYPOTHESES Hip fracture incidence rates in Lebanon approximate those of Northern countries, and show the same characteristics, particularly the exponential increase with age, higher incidence in women, and a recent trend of rate leveling in women but not in men. MATERIALS AND METHODS A national database of hip fracture cases admitted to hospitals in Lebanon in 2007 was created. Crude and age-adjusted incidence rates were calculated at 5-year intervals for individuals over age 50. These rates were also standardized to the 2000 United States population, and compared to those of other countries. Projected incidence rates in Lebanon in 2020 and 2050 were also calculated. RESULTS A total of 1199 patients were included in the study. The crude annual incidence rate in individuals over 50 was 147 per 100,000 individuals, 132 per 100,000 males and 160 per 100,000 females, with a female-to-male ratio of 1.2. The age-standardized annual incidence rates (per 100,000) were 180 in males and 256 in females. Assuming unchanged healthcare parameters, the projected crude incidence rates for people over 50 are expected to reach 174 and 284 per 100,000 in 2020 and 2050 respectively. CONCLUSIONS Lebanese hip fracture rates are lower than Northern countries, but show many similar characteristics such as an exponential increase with age, a higher incidence in women, and clues of a leveling of rates in women but not in men. Numbers are expected to increase substantially in the coming decades. LEVEL OF EVIDENCE Level IV. Epidemiological study.