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Dive into the research topics where R. Eugene Zierler is active.

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Featured researches published by R. Eugene Zierler.


Journal of the American College of Cardiology | 2011

2011 ACCF/AHA Focused Update of the Guideline for the Management of Patients With Peripheral Artery Disease (Updating the 2005 Guideline) A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines

Thom W. Rooke; Alan T. Hirsch; Sanjay Misra; Anton N. Sidawy; Joshua A. Beckman; Laura K. Findeiss; Jafar Golzarian; Heather L. Gornik; Jonathan L. Halperin; Michael R. Jaff; Gregory L. Moneta; Jeffrey W. Olin; James C. Stanley; Christopher J. White; John V. White; R. Eugene Zierler

Keeping pace with the stream of new data and evolving evidence on which guideline recommendations are based is an ongoing challenge to timely development of clinical practice guidelines. In an effort to respond promptly to new evidence, the American College of Cardiology Foundation/American Heart Association (ACCF/AHA) Task Force on Practice Guidelines (Task Force) has created a “focused update” process to revise the existing guideline recommendations that are affected by the evolving data or opinion. New evidence is reviewed in an ongoing fashion to more efficiently respond to important science and treatment trends that could have a major impact on patient outcomes and quality of care. Evidence is reviewed at least twice a year, and updates are initiated on an as-needed basis and completed as quickly as possible while maintaining the rigorous methodology that the ACCF and AHA have developed during their partnership of >20 years. These updated guideline recommendations reflect a consensus of expert opinion after a thorough review primarily of late-breaking clinical trials identified through a broad-based vetting process as being important to the relevant patient population, as well …


Circulation | 1998

Prospective Study of Atherosclerotic Disease Progression in the Renal Artery

Michael T. Caps; Claudio Perissinotto; R. Eugene Zierler; Nayak L. Polissar; Robert O. Bergelin; Michael J. Tullis; Kim Cantwell-Gab; Robert C. Davidson; D. Eugene Strandness

BACKGROUND The aim of this study was to determine the incidence of and the risk factors associated with progression of renal artery disease in individuals with atherosclerotic renal artery stenosis (ARAS). METHODS AND RESULTS Subjects with >/=1 ARAS were monitored with serial renal artery duplex scans. A total of 295 kidneys in 170 patients were monitored for a mean of 33 months. Overall, the cumulative incidence of ARAS progression was 35% at 3 years and 51% at 5 years. The 3-year cumulative incidence of renal artery disease progression stratified by baseline disease classification was 18%, 28%, and 49% for renal arteries initially classified as normal, <60% stenosis, and >/=60% stenosis, respectively (P=0.03, log-rank test). There were only 9 renal artery occlusions during the study, all of which occurred in renal arteries having >/=60% stenosis at the examination before the detection of occlusion. A stepwise Cox proportional hazards model included 4 baseline factors that were significantly associated with the risk of renal artery disease progression during follow-up: systolic blood pressure >/=160 mm Hg (relative risk [RR]=2.1; 95% CI, 1.2 to 3.5), diabetes mellitus (RR=2.0; 95% CI, 1.2 to 3.3), and high-grade (>60% stenosis or occlusion) disease in either the ipsilateral (RR=1.9; 95% CI, 1.2 to 3.0) or contralateral (RR=1.7; 95% CI, 1.0 to 2.8) renal artery. CONCLUSIONS Although renal artery disease progression is a frequent occurrence, progression to total renal artery occlusion is not. The risk of renal artery disease progression is highest among individuals with preexisting high-grade stenosis in either renal artery, elevated systolic blood pressure, and diabetes mellitus.


Circulation | 2011

2011 ACCF/AHA focused update of the guideline for the management of patients with peripheral artery disease (Updating the 2005 Guideline)

Thom W. Rooke; Alan T. Hirsch; Sanjay Misra; Anton N. Sidawy; Joshua A. Beckman; Laura K. Findeiss; Jafar Golzarian; Heather L. Gornik; Jonathan L. Halperin; Michael R. Jaff; Gregory L. Moneta; Jeffrey W. Olin; James C. Stanley; Christopher J. White; John V. White; R. Eugene Zierler

Keeping pace with the stream of new data and evolving evidence on which guideline recommendations are based is an ongoing challenge to timely development of clinical practice guidelines. In an effort to respond promptly to new evidence, the American College of Cardiology Foundation/American Heart Association (ACCF/AHA) Task Force on Practice Guidelines (Task Force) has created a “focused update” process to revise the existing guideline recommendations that are affected by the evolving data or opinion. New evidence is reviewed in an ongoing fashion to more efficiently respond to important science and treatment trends that could have a major impact on patient outcomes and quality of care. Evidence is reviewed at least twice a year, and updates are initiated on an as-needed basis and completed as quickly as possible while maintaining the rigorous methodology that the ACCF and AHA have developed during their partnership of >20 years. These updated guideline recommendations reflect a consensus of expert opinion after a thorough review primarily of late-breaking clinical trials identified through a broad-based vetting process as being important to the relevant patient population, as well …


Journal of Vascular Surgery | 1994

Natural history of atherosclerotic renal artery stenosis: A prospective study with duplex ultrasonography

R. Eugene Zierler; Robert O. Bergelin; Janette A. Isaacson; D. Eugene Strandness

PURPOSE Although the prevalence of renal artery stenosis in patients with peripheral arterial disease is in the range of 30% to 40%, the role of renal revascularization in patients without severe hypertension or kidney failure is controversial. Duplex scanning is a noninvasive technique that is ideally suited for screening and follow-up of renal artery disease. The purpose of this study was to document the natural history of renal artery stenosis in patients who were not candidates for immediate renal revascularization. METHODS Eighty-four patients with at least one abnormal renal artery detected by duplex scanning were recruited from patients being screened for renal artery stenosis. Of the 168 renal artery/kidney sides, 29 were excluded (15 prior interventions, 6 nondiagnostic duplex scans, 8 presumed nonatherosclerotic lesions), leaving 80 patients with 139 sides for the follow-up protocol. Renal arteries were classified as normal, less than 60% stenosis, 60% or greater stenosis, or occluded by use of previously validated criteria. RESULTS The study group included 36 men and 44 women with a mean age of 66 years who were monitored for a mean interval of 12.7 months. The initial status of the 139 renal arteries was normal in 36, less than 60% stenosis in 35, 60% or greater stenosis in 63, and occluded in 5. Although none of the initially normal renal arteries showed disease progression, the cumulative incidence of progression from less than 60% to 60% or greater renal artery stenosis was 23% +/- 9% at 1 year and 42% +/- 14% at 2 years. All four renal arteries that progressed to occlusion had 60% or greater stenoses at the initial visit, and for those sides with a 60% or greater stenosis, the cumulative incidence of progression to occlusion was 5% +/- 3% at 1 year and 11% +/- 6% at 2 years. The mean decrease in kidney length associated with progression of renal artery stenosis to occlusion was 1.8 cm. CONCLUSIONS Progression of renal artery stenosis, as defined in this study, occurs at a rate of approximately 20% per year. Progression to occlusion is associated with a marked decrease in kidney length. Whether this natural history can be improved by earlier intervention for renal artery stenosis remains to be determined.


Journal of Vascular Surgery | 1986

Noninvasive diagnosis of renal artery stenosis by ultrasonic duplex scanning.

Ted R. Kohler; R. Eugene Zierler; Robert Martin; Stephen C. Nicholls; Robert O. Bergelin; Andris Kazmers; Kirk W. Beach; D. Eugene Strandness

We retrospectively studied the results of duplex scanning for evaluation of renal artery disease in 158 patients. Satisfactory examinations were achieved in 144 patients (90%). Arteriograms were available for 43 renal arteries. We used the ratio of the peak velocities in the renal artery and the aorta (RAR) to separate nonstenotic arteries (less than 60% diameter reduction) from stenotic arteries (greater than 60% diameter reduction). With an RAR of greater than 3.5 to indicate stenotic lesions, duplex scanning had a sensitivity of 91% (20 of 22 diseased arteries correctly identified) and specificity of 95% (20 of 21 normal or insignificantly diseased arteries correctly identified). One of four occluded arteries was incorrectly interpreted as patent because of misidentification of a collateral vessel. Prospective studies will be necessary to validate this test and establish other criteria for a more detailed classification of renal artery stenosis. The ratio of the end-diastolic to peak systolic velocities in the renal artery (EDR) tended to decrease with increasing serum creatinine levels, presumably because renal vascular resistance increases with end-stage parenchymal disease. EDR may prove useful in the detection of advanced parenchymal disease before renal artery revascularization is attempted.


American Journal of Hypertension | 1995

A prospective study of disease progression in patients with atherosclerotic renal artery stenosis

R. Eugene Zierler; Robert O. Bergelin; Robert C. Davidson; K. Cantwell-Cab; Nayak L. Polissar; D.E. Strandness

The natural history of renal artery stenosis (RAS) has been difficult to document because serial arteriography is rarely justified. Duplex scanning is a noninvasive technique that is ideally suited for both screening and follow-up of RAS. In this approach, renal arteries are classified as normal, < 60% stenosis, > or = 60% stenosis, or occluded, and disease progression is defined as a change in the duplex classification. The purpose of this study was to determine the rate of disease progression in atherosclerotic RAS by serial duplex scanning. At least one abnormal renal artery was identified in each of 76 patients being screened for RAS. Of the 152 renal arteries, 20 were excluded (14 prior interventions, 5 occlusions, 1 technically inadequate duplex scan), leaving 132 for the natural history follow-up protocol. The patient group included 36 men and 40 women, with a mean age of 67 years, who were followed for a mean of 32 months (maximum 55 months). The initial status of the 132 renal arteries was normal in 36, < 60% stenosis in 35, and > or = 60% stenosis in 61. The cumulative incidence of progression from normal to > or = 60% RAS was 0% at 1 year, 0% at 2 years, and 8% at 3 years. The cumulative incidence of progression from < 60% to > or = 60% RAS was 30% at 1 year, 44% at 2 years, and 48% at 3 years. All 4 renal arteries that progressed to occlusion had > or = 60% stenoses at the initial visit, and for those arteries with a > or = 60% stenosis, the cumulative incidence of progression to occlusion was 4% at 1 year, 4% at 2 years, and 7% at 3 years. Progression of RAS occurred at an average rate of 7% per year for all categories of baseline disease combined. Progression of atherosclerotic RAS is relatively common, particularly from < 60% to > or = 60% stenosis.


Journal of Vascular Surgery | 1989

Long-term follow-up and clinical outcome of carotid restenosis******

Dean A. Healy; R. Eugene Zierler; Stephen C. Nicholls; Alexander W. Clowes; Jean F. Primozich; Robert O. Bergelin; D. Eugene Strandness

The efficacy of carotid endarterectomy is dependent on the inherent ability of the operation to prevent stroke as well as the incidence of restenosis and associated symptoms. To examine the long-term effects of restenosis, 301 patients having carotid endarterectomy were followed by serial duplex scanning for an average of 4 years. Carotid restenosis, defined as 50% or greater diameter reduction by duplex scanning, occurred after 78 of the endarterectomies; regression of recurrent stenosis occurred in 20 arteries. By life-table analysis the cumulative incidence of restenosis at 7 years was 31%, and the cumulative incidence of regression was 10%. Thus the prevalence of recurrent stenosis at 7 years was 21%. Restenosis developed in women more frequently than men (p = 0.01). Transient ischemic attack occurred in 12% of patients with restenosis, and stroke occurred in 3%; however, the cumulative incidence of stroke or transient ischemic attack was not statistically different in those patients with and without restenosis. Similarly, cumulative survival at 7 years was no different. Carotid restenosis usually occurs early in the postoperative period and tends to regress or remain stable during long-term follow-up. A conservative approach to treatment appears justified, since transient ischemic attacks and stroke were rarely associated with restenosis.


Journal of Vascular Surgery | 1992

Intraabdominal paraanastomotic aneurysms after aortic bypass grafting

James M. Edwards; Sharlene A. Teefey; R. Eugene Zierler; Ted R. Kohler

Although the reported incidence of intraabdominal paraanastomotic aneurysms after abdominal aortic bypass grafting ranges from 1% to 15%, the true incidence is unknown because few studies have used routine, serial radiographic or sonographic imaging studies. Since July 1, 1988, we have used yearly abdominal sonography examinations to monitor our patients with aortic grafts. In the first 33 months we studied 138 patients. Medical records of 111 of these were available for review and form the basis of this report. Eleven patients (10%) were found to have intraabdominal paraanastomotic aneurysms ranging in overall size from 4.1 to 6.2 cm (mean, 5.0 +/- 0.7 cm). The mean time between operation and detection of an aneurysm was 144 +/- 101 months (range, 8 to 336 months). Three paraanastomotic aneurysms occurred within 3 years of operation, and the remaining eight occurred late (7 to 28 years). By life-table analysis, the incidence of paraanastomotic aneurysms was 27% at 15 years. Paraanastomotic aneurysms were classified as either pseudoaneurysms (presumed disruption of the anastomotic suture line, n = 7) or as true aneurysms (widening of the adjacent aorta, n = 4). True aneurysms occurred only after repair of an abdominal aortic aneurysm, whereas pseudoaneurysms were more frequent after bypass for occlusive disease. The finding of paraanastomotic aneurysms in 10% of our patients supports the use of yearly sonography for routine follow-up after aortic grafting.


Journal of Vascular Surgery | 1988

Perioperative and late outcome in patients with left ventricular ejection fraction of 35% or less who require major vascular surgery

Andris Kazmers; Manuel D. Cerqueira; R. Eugene Zierler

Survival in patients with diminished left ventricular ejection fraction (EF) is reduced after major vascular surgery. The objective of this study was to determine perioperative (30-day) and subsequent outcome after major vascular surgery in those with severe cardiac dysfunction, defined by EF being 35% or less (normal EF greater than 50%). From Aug. 1, 1984 to Jan. 1, 1988, 35 patients with EF equal to 27.7% +/- 6.1% (mean +/- 1 standard deviation) have required 47 major vascular procedures: 53% (n = 25) were limb revascularizations; 21% (n = 10) were direct aortoiliac aneurysm repairs: 23% (n = 11) were carotid endarterectomies: one patient had transaortic renal endarterectomy. Two deaths occurred within the first 30 days, yielding a 4.3% perioperative mortality rate (2 of 47 procedures). The cumulative mortality rate for the entire group during follow-up of 410 +/- 390 days was 40% (14 of 35 patients). Most late deaths (71%) occurred within the first 6 months after surgery and each was due to cardiovascular complications. Survival for those with an EF of 29% or less was significantly worse than for those with an EF greater than 29%, determined by life-table analysis (p less than 0.012, Mantel-Cox). The cumulative mortality rate was 59% with an EF of 29% or less and 18% in those with an EF greater than 29% (p less than 0.029, two-tailed Fisher exact test). The perioperative mortality rate for those with an EF of 35% or less who require major vascular surgery is acceptable, but overall survival during follow-up is diminished.(ABSTRACT TRUNCATED AT 250 WORDS)


Journal of Vascular Surgery | 1997

Results of percutaneous transluminal angioplasty for atherosclerotic renal artery stenosis: A follow-up study with duplex ultrasonography

Michael J. Tullis; R. Eugene Zierler; David J. Glickerman; Robert O. Bergelin; Kim Cantwell-Gab; D. Eugene Strandness

PURPOSE The short and long-term anatomic results of percutaneous transluminal renal angioplasty (PTRA) in the treatment of atherosclerotic renovascular disease have been poorly documented because of a lack of follow-up arteriography. The purpose of this study was to evaluate the anatomic results of PTRA with serial duplex examinations. METHODS The records of 41 patients who underwent 52 primary PTRA procedures and had subsequent duplex follow-up of at least 6 months were reviewed. After PTRA, renal arteries were classified as normal, < 60% stenosis, > or = 60% stenosis, or occluded on the basis of previously validated duplex criteria. RESULTS The study group included 26 men and 15 women with a mean age of 65 years, who were observed for a mean interval of 34 months. Endovascular stents were placed in 12 of the 52 arteries. The initial post-PTRA renal artery stenosis classification (based on arteriography or duplex scan) was normal in 23, < 60% in 19, and > or = 60% in 10. The cumulative incidence of restenosis from normal to > or = 60% was 13% at 1 year and 19% at 2 years. The cumulative incidence of restenosis from < 60% to > or = 60% was 44% at 1 year and 55% at 2 years. The cumulative incidence of progression from > or = 60% to occlusion was 10% at 2 years. Although 83% of the 12 stented arteries and only 33% of the 40 nonstented arteries were normal immediately after PTRA, after 1 year the stented renal arteries showed a 44% restenosis rate, whereas the nonstented renal arteries showed a 18% restenosis rate (p = 0.087). CONCLUSIONS Restenosis after PTRA for atherosclerotic disease is relatively common and correlates with the initial anatomic result. Although PTRA with stent placement yields superior immediate technical results, the high early restenosis rate is disturbing.

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Kirk W. Beach

University of Washington

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Jeffrey W. Olin

Icahn School of Medicine at Mount Sinai

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