R.H. Flocks

Comparison of flutamide (SCH-13521) and diethylstilbestrol in untreated advanced prostatic cancer.

A double-blind study comparing the efficacy of flutamide (SH-13521) and diethylstilbestrol in 15 patients with advanced, previously untreated adenocarcinoma in the prostate in herein presented. Patients receiving diethylstilbestrol, 1 mg. daily, remained stable without evidence of progression of their disease for an average of 25.6 weeks while those receiving either high-or low-dose flutamide showed no objective progression for an average of thirty weeks. There were no complete remissions, and no signficant side effects were seen with either of these agents. In this small series of hormonally untreated Stage D prostatic cancer patients, neither agent displayed significant superiority.

Cryosurgery for carcinoma of prostate

Abstract One hundred fifty-four patients with histologically proved prostatic cancer have been treated by cryosurgery via the open perineal route. This approach provides excellent access to the primary lesion, is well tolerated by the patients, and is not followed by a significant incidence of urinary incontinence. Radiologic evidence of metastatic regression was observed in 1 patient, aged seventy-nine, with Stage D disease. Subjective relief of bone pain occurred in 75 per cent of those at risk in whom a hormonal cause for pain relief can be excluded. Although the frequency of objective metastatic regression has been low, perineal cryosurgery has proved effective in the destruction of the local lesion. Two-year patient survival was significantly less in those having previous hormonal therapy.

Follow-up study of one hundred cases of carcinoma of the prostate treated with radioactive gold.

In previous papers we have reported our experience in the treatment with radioactive gold of moderately advanced carcinoma of the prostate where local extension made radical surgery of little avail and where distant metastases could not be demonstrated. We emphasized that for this type of treatment it was important to select the patients carefully. This careful selection has remained essentially unchanged in all subsequent work. Patients with lesions which were definitely operable (Group I) have been reserved for radical surgical approach, while those with distant metastases or widespread primary lesions (Group III) have been treated by conservative palliative therapy. The importance of collaboration between the urologist and radiologist in the carrying out of this treatment was also emphasized. The work was undertaken in an effort to salvage some of those patients who would otherwise be treated only palliatively and symptomatically by the use of hormones, orchiectomy, and limited surgical procedures. Fro...