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Featured researches published by R. K. Goel.


Bioorganic Chemistry | 2014

Synthesis, biological evaluation and molecular modeling study of pyrazole derivatives as selective COX-2 inhibitors and anti-inflammatory agents.

Ashish Kumar Tewari; Ved Prakash Singh; Pratima Yadav; Garima Gupta; Amit Kumar Singh; R. K. Goel; Pravin Shinde; C. Gopi Mohan

A novel series of pyrazole derivatives were synthesized and evaluated in vivo for their anti-inflammatory activity in carrageenan-induced rat paw edema model. Among all compounds, 5a, and 5b showed comparable anti-inflammatory activity to Nimesulide, the standard drug taken for the studies. In silico (docking) studies were carried out to investigate the theoretical binding mode of the compounds to target the cyclooxygenase (COX-2) using Autodock 4.2.


Indian journal of physiology and pharmacology | 2007

Effect of ethanolic extract of Eugenia jambolana seeds on gastric ulceration and secretion in rats.

Aditi Chaturvedi; M. S. Mohan Kumar; G. Bhawani; Harish Chaturvedi; Mohan Kumar; R. K. Goel


Indian Journal of Experimental Biology | 2006

Effect of plantain banana on gastric ulceration in NIDDM rats: Role of gastric mucosal glycoproteins, cell proliferation, antioxidants and free radicals

M Mohan Kumar; Mitesh Joshi; T. Prabha; M. Dorababu; R. K. Goel


Chemical & Pharmaceutical Bulletin | 2010

Novel anti-inflammatory agents based on pyrazole based dimeric compounds; design, synthesis, docking and in vivo activity.

Ashish Kumar Tewari; Priyanka Srivastava; Ved Prakash Singh; Amit Kumar Singh; R. K. Goel; Chethampadi Gopi Mohan


Indian Journal of Experimental Biology | 2010

Immunomodulatory effect of Moringa oleifera Lam. extract on cyclophosphamide induced toxicity in mice.

Anamika Gupta; Manish Kumar Gautam; Rahul Kunwar Singh; M. Vijay Kumar; Ch. V. Rao; R. K. Goel; Shampa Anupurba


Indian Journal of Experimental Biology | 2006

Teratogenicity of Asparagus racemosus Willd. root, a herbal medicine

R. K. Goel; T. Prabha; M Mohan Kumar; M. Dorababu; Prakash; G. Singh


Singapore Medical Journal | 2008

Teratogenic effects of the anticonvulsant gabapentin in mice

Prakash; Latha V. Prabhu; Rai R; Mangala M. Pai; Yadav Sk; Sampath Madhyastha; R. K. Goel; Gajendra Singh; Nasar Ma


Indian Journal of Experimental Biology | 2013

Healing effects of Aegle marmelos (L.) Correa fruit extract on experimental colitis.

Manish Kumar Gautam; Rr Ghatule; A. Singh; Purohit; M Gangwar; M Mohan Kumar; R. K. Goel


BMC Complementary and Alternative Medicine | 2013

Healing effects of Musa sapientum var. paradisiaca in diabetic rats with co-occurring gastric ulcer: cytokines and growth factor by PCR amplification

Mohan Kumar; Manish Kumar Gautam; Amit Kumar Singh; R. K. Goel


Journal of Natural Remedies | 2007

Status of Mucosal Offensive and Defensive Factors in Pylorus Ligated-Induced Gastric Ulceration in NIDDM Rats vis-a-vis Plantain Banana

Mitesh Joshi; M. Mohan Kumar; T. Prabha; M. Dorababu; R. K. Goel

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Amit Kumar Singh

Indian Institute of Technology (BHU) Varanasi

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M. Dorababu

Institute of Medical Sciences

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Ch. V. Rao

Banaras Hindu University

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Gajendra Singh

Institute of Medical Sciences

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Mitesh Joshi

Sardar Patel University

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Mohan Kumar

Institute of Medical Sciences

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A. Singh

Central Drug Research Institute

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