R Kalyani

Sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid

Sclerosing mucoepidermoid carcinoma with eosinophilia (SMECE) is a recently described carcinoma of the thyroid gland associated with Hashimotos thyroiditis and considered to have a relatively indolent clinical course. We present a 65-year-old female, clinically euthyroid, who presented with a thyroid swelling since last 8 months along with right-sided cervical lymphadenopathy. Fine needle aspiration cytology suggested poorly differentiated carcinoma along with the involvement of the lymphnodes while histopathological examination showed features of SMECE with metastatic deposits in the right-sided cervical lymphnodes.

Malignant peripheral nerve sheath tumor with divergent differentiation.

A malignant peripheral nerve sheath tumor (MPNST) is an uncommon spindle cell sarcoma accounting for approximately 5% of all soft tissue sarcomas. A 55-year-old female with a right suprarenal tumor showed MPNST with additional foci of epithelioid, rhabdomyoblastic, osteogenic and lipogenic differentiation. Although the capacity of MPNST to undergo epithelioid, rhabdomyoblastic, osteogenic and very rarely lipogenic differentiation is reported in literature, the occurrence of all these differentiation in one case has not been described in literature before. To the best of our knowledge, this is only the second MPNST case with lipomatous differentiation.

Retroperitoneal cystic schwannoma: A case report with review of literature

The occurrence of retroperitoneal schwannoma is uncommon and its presence may only be expressed by insidious onset of nonspecific symptoms such as vague abdominal pain. Imaging modalities like computed tomography and magnetic resonance imaging may demonstrate the tumor, but due to heterogeneity and degeneration in some tumors, it may mimic malignancy. So, fine needle aspiration cytology followed by tissue sampling through needle biopsies may be essential to confirm the diagnosis prior to the surgery. This case is reported for its rare clinical presentation, having duration of more than 40 years with cystic degenerative changes.

Giant chondroid syringoma with divergent differentiation: Cyto-histo-immuno correlation

Chondroid syringoma is a rare benign skin adnexal tumor of eccrine/apocrine origin affecting commonly the head and neck region. It is also called as mixed tumor of skin because of the presence of both the epithelial and mesenchymal components. There are very few case reports of chondroid syringoma diagnosed on fine needle aspiration cytology (FNAC). We hereby report a case of giant chondroid syringoma occurring over the lower back in a 50-year-old male, diagnosed initially on cytology and confirmed by histopathology. This case is reported for its unusual size and site of occurrence. We describe the clinical features, cytology, histopathology, immunohistochemistry, and differential diagnosis of giant chondroid syringoma along with review of literature.

Vulval schwannoma: A cytological diagnosis

Schwannomas are the most common peripheral nerve sheath tumors, the frequent sites of involvement being the head and neck, the flexor aspect of the limbs, especially near the elbow, wrist, knee, and trunk. Involvement of the female genital tract is extremely rare. We present one such rare case of a solitary vulval schwannoma which was diagnosed by fine needle aspiration cytology in a 48 year-old female, and confirmed by histopathological examination.

Fine-needle aspiration findings in epithelioid myoepithelioma of the parotid gland: A diagnostic pitfall

The cytological features of myoepithelioma of the parotid gland are documented in only a few case reports. We describe the fine-needle aspiration cytological findings in a case of epithelioid myoepithelioma of the parotid gland in a 43-year-old male. The differential diagnosis with other salivary gland neoplasms is discussed.

An unusual histomorphological presentation of fibroadenoma

A 59-year-old man with known history of rectal carcinoma completed adjuvant chemotherapy and radiotherapy a month back. He presented with severe intractable hiccoughs due to which he was unable to sleep the entire night. There was no history of fever, vomiting or abdominal pain. He was passing urine and stools normally. CT abdomen showed diffuse wall thickening with target appearance of the distal ileal loops with mild proximal dilatation of smallbowel loops. Features were suggestive of inflammatory wall thickening — likely to be radiation enteritis. The general physical and systemic examinations were unremarkable, not indicative of involvement of other organ systems. He was admitted and started on Piperacillin-Tazobactam, Amikacin, IV fluids, Potchlor, Rantac, Baclofen and Perinorm. His general condition improved slowly after 3 days. On discharge, the patient’s condition was stable and hiccoughs decreased. The patient did not visit for follow-up.