R. Leenen

Abdominal diameters as indicators of visceral fat: comparison between magnetic resonance imaging and anthropometry

The aim of the present study was to investigate the usefulness of abdominal diameters to indicate visceral fat, their relationship with serum lipids and their capability of detecting changes in visceral fat. Before and after weight loss, visceral and subcutaneous fat, and the sagittal and transverse diameters were assessed by magnetic resonance imaging (MRI) in forty-seven obese men and forty-seven premenopausal obese women with an initial body mass index of 31.0 (SD 2.4) kg/m2. In a subsample (n 21), diameters, were also measured by anthropometry in the standing and supine positions. They were strongly correlated with the diameters derived from the MRI scans. Serum levels of total and HDL-cholesterol and triacylglycerol were measured before weight loss. In women the sagittal diameter correlated less strongly with visceral fat than anthropometrically-assessed waist circumference and waist:hip ratio (WHR). In men these associations were comparable. Changes in visceral fat with weight loss were more strongly correlated with changes in the sagittal diameter and sagittal:transverse diameter ratio (STR) than with changes in waist circumference or WHR in men. In women, changes in the anthropometric variables and the separate diameters (except STR) were not associated with visceral fat loss. In men, but not in women, both the sagittal diameter and the visceral fat area were related to serum lipids. It is concluded that the sagittal diameter and STR may have advantages over waist circumference and WHR in men, particularly in assessing changes in visceral fat, but this could not be demonstrated in women. The ability to predict visceral fat from circumferences and diameters or their ratios is, however, limited in obese men and women.

Visceral fat accumulation measured by magnetic resonance imaging in relation to serum lipids in obese men and women

In 91 apparently healthy obese subjects (45 premenopausal women and 46 men) the associations between specific fat depots and serum lipids were studied. Magnetic resonance imaging was used to quantify fat depots at abdominal and hip level. In women, an accumulation of visceral fat was associated with a less favourable lipid profile, even after adjustment for age and body fat percentage: higher triglycerides levels (P less than 0.001), lower levels of HDL-cholesterol (P less than 0.01) and a diminished HDL-cholesterol/LDL-cholesterol ratio (P less than 0.01). In men, however, the significant inverse relationship between an abundance of visceral fat and the HDL-cholesterol/LDL-cholesterol ratio and the significant positive correlations with total-, LDL-cholesterol and triglycerides disappeared after adjustment for age and fat percentage. Within each sex, subcutaneous fat neither at abdominal level nor at hip level was significantly related to serum lipids. It is concluded that there are gender differences in the associations between visceral fat accumulation and serum lipids.

Visceral fat loss measured by magnetic resonance imaging in relation to changes in serum lipid levels of obese men and women.

The effect of weight reduction on serum lipids in relation to visceral fat accumulation was studied in 78 healthy obese subjects (40 premenopausal women and 38 men) aged 27-51 years and with an initial body mass index of 30.7 +/- 2.2 kg/m2 (mean +/- SD). The subjects received a 4.2 MJ/day energy-deficit diet for 13 weeks. Magnetic resonance imaging was used to assess abdominal fat areas before and after weight loss. Weight reductions of 12.6 +/- 3.2 kg in men and 11.7 +/- 3.8 kg in women resulted in larger reductions in the fasting serum levels of total cholesterol (p < 0.05), low density lipoprotein cholesterol (p = 0.06), and triglycerides (p < 0.01) and a larger increase in the high density lipoprotein cholesterol/low density lipoprotein cholesterol ratio (p = 0.05) in men compared with women. Men also lost more visceral fat (p < 0.0001), whereas the reductions in the total and subcutaneous abdominal fat depots were similar. In women, visceral fat loss was significantly related with an increase of the high density lipoprotein cholesterol level, independent of the degree of total fat loss. In men, however, no significant correlations were observed between changes in visceral fat and any of the serum lipids. Comparisons of average changes in obese men and women suggest that visceral fat loss is associated with an improvement of the serum lipid profile. However, correlation analysis does not support a critical role of visceral fat in determining serum lipid concentrations on an individual level, except for an improvement of the high density lipoprotein cholesterol level with visceral fat loss in obese women.

Body composition and weight reduction in relation to antigen and activity of plasminogen activitor inhibitor (PAI-1) in overweight individuals

Tissue plasminogen activator inhibitor type 1 (PAI-1) plasma activity and antigen levels were determined in 22 healthy overweight individuals (11 females and 11 males), before and after a period of 13 weeks during which the participants were subjected to a 4.2 MJ deficient diet. The diet intervention resulted in a significant reduction in anthropometric variables under study (P<0.005). PAI-1 activity and antigen decreased significantly in both females and males (P<0.01), Lp(a) decreased in females only (P<0.01) and insulin (P<0.01) and triglycerides (P<0.005) were reduced in males only. Correlation between anthropometric variables and blood parameters were higher in females than in males. Results from this study support the beneficial effects of weight reduction on important atherogenic components.