R. M. Fink

CARBON-PHOSPHORUS HETEROCYCLES. STRUCTURAL ANALYSIS OF 1,2,3,4-TETRAHYDRO-1,4-DIMETHYL-1-PHENYL-PHOSPHINOLINIUM HEXAFLUOROPHOSPHATE AND 1,2,3,4-TETRAHYDRO-1-ETHYL-4-METHYL-1-PHENYLPHOS-PHINOLINIUM HEXAFLUOROPHOSPHATE. A NOVEL COCRYSTALLIZATION OF STEREOISOMERS OF THE FORMER

Abstract An analysis is provided for the cyclization of 2-butenyldiphenylmethylphosphonium bromide and 2-butenyldiphenylethylphosphonium bromide via the use of 115% polyphosphoric acid (PPA) at 160°C. In addition, the X-ray diffraction analysis of the crystalline products 1,2,3,4-tetrahydro-1,4-dimethyl-1-phenylphosphinolinium hexafluorophosphate and 1,2,3,4-tetrahydro-1-ethyl-4-methyl-1-phenylphosphinolinium hexafluorophosphate is discussed. An unusual cocrystallization occurs with the diastereoisomers of 1,2,3,4-tetrahydro-1,4-dimethyl-1-phenylphosphinolinium hexafluorophosphate which can be seen in the crystalline structure. Some screening data furnished by the National Cancer Institute is also evaluated in terms of carcinostatic activity versus the type of substitution on phosphorus.

METASTATIC ADENOCARCINOMA OF THE THYROID WITH ELEVATED BASAL METABOLISM: RADIOIODINE STUDIES

Excerpt Increasing interest has been shown in the use of radioiodine as a tool for the clinical investigation and therapy of various thyroid maladies. This has followed upon the availability of lar...