R. N. Iyer

Chemotherapy of cestode infections

The cestode infections are one of the most common intestinal parasitic diseases responsible for several health hazards in man and animals all over the world. Surprisingly, the chemotherapy of these parasites remained backward till the beginning of past decade which witnessed a considerable progress in this direction. Today, cestodiasis is considered as a major helminth problem both in advanced and developing countries which not only threat the health and general well being of humans but also hamper the economy of milk, meat and wool producing regions of the world. The incidence of cestode infections has always been alarming [1–3], however recently it has been estimated [4] that 80,000,000 people suffer from Taenia saginata and T. solium and there are 2,000,000 cases of Diphyllobothrium latum infection throughout the world.

An Unusual N-Dealkylation-Neighbouring Group Participations of Oximino Function [1]

Abstract Reaction of N,N-dialkyl-β-aminoketones (5 and 7) with hydroxylamine hydrochloride in pyridine results in the dealkylated oximine (6). The mechanism of this N-dealkylation may be explained as due to the neighbouring group participation of the oximine formed during the reaction.

A Convenient Synthesis of Naphth[2′,3′ : 5,6]- and [1′,2′ : 5,6]-1,3-oxazino[3,2-b]benzimidazoles and Benzoxazolo[3,2-b] [l,3]quinazolone - Mechanism of Thiophosgene Heteroeyelisation [1]

Abstract Reaction of thiophosgene or phosgene on 2′-aminonaphthanilides (2, 5) gave the corresponding 2-substituted-6-oxonaphth[2′,3′: 5,6]-1,3-oxazino[3,2-b]benzimidazoles (3) and 6-oxonaphth[1′,2′:5,6]-1,3-oxazino[3,2-b]benzimidazoles (6) respectively. The mechanism of such reactions has been studied by carrying reaction between 2′-hydroxy - anthranilide (7 a) and thiophosgene in acidic and basic media.

2′-Chloro-1-hydroxy-2-naphthanilide-4'- isothiocyanate — a New Cestodicidal Agent [1 ]

2′-Chloro-1-hydroxy-2-naphthanilide-4′-isothiocyanate (4) has been synthesized as the structural analogue of yomesan (1) and was found to be active against experimental dwarf tapeworm Hymenolepis nana infection in rats at an oral dose of 7.5 mg/kg.