R. N. Warrener

The synthesis of polarofacial spacer molecules: a new twist in the coupling of ring strained olefins with oxadiazoles.

Abstract New approaches to the synthesis of rigid spacer molecules in which an oxygen-bridge bestows the facial polarity is described: attempts to couple 7-oxanorbornenes together using 1,3,4-oxadiazoles yields inverted, non linear products in a stereospecific reaction which differs significantly from that known to obtain with norbornenes.

The synthesis of spacer molecules containing an alcohol group at each terminus

Abstract New spacer molecules are reported which contain alcohol functional groups at each end of the rigid carbocyclic framework. Simple coupling and extension reactions are used in their production thereby offering wide versatility in the shape, length and physical properties of these molecules.

Transfer technology III: The synthesis of bridged cyclic polyenes using a new retrosynthetic algorithm as a guide.

Abstract This route to bridged [4] and [8] annulenes employs a new retrosynthetic algorithm, transannular π-bond pairing, as its basis and improved transfer reagents for substituted cyclobutadienes to achieve the synthesis.

A transannular π-bond pairing approach to the synthesis of 1,3-cyclopentadiene diesters and maleimido-oxepines and a report on their isomerisation.

Abstract Polycyclobutanoid compounds containing an end-fused 3-membered ring are central to the synthesis of the title target molecules: a new mode for their production is presented. Cyclopentadiene 1,3-diester is isolated and its isomerisation studied. Intermediates supporting the oxygen-walk isomerisation of maleimido-oxepines are isolated.