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Dive into the research topics where R. Rodrigues is active.

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Featured researches published by R. Rodrigues.


Physiological Genomics | 2016

Association of ADAMTS7 gene polymorphism with cardiovascular survival in coronary artery disease.

Pereira A; R. Palma Dos Reis; R. Rodrigues; A.C. Sousa; S. Gomes; S. Borges; I. Ornelas; Ana Isabel Freitas; Graça Guerra; Eva Henriques; M. Rodrigues; S. Freitas; C. Freitas; António Brehm; Décio Pereira; Maria Isabel Mendonça

Recent genetic studies have revealed an association between polymorphisms at the ADAMTS7 gene locus and coronary artery disease (CAD) risk. Functional studies have shown that a CAD-associated polymorphism (rs3825807) affects ADAMTS7 maturation and vascular smooth muscular cell (VSMC) migration. Here, we tested whether ADAMTS7 (A/G) SNP is associated with cardiovascular (CV) survival in patients with established CAD. A cohort of 1,128 patients with angiographic proven CAD, who were followed up prospectively for a mean follow-up period of 63 (range 6-182) mo, were genotyped for rs3825807 A/G. Survival statistics (Cox regression) compared heterozygous (AG) and wild-type (AA) with the reference homozygous GG. Kaplan-Meier (K-M) survival curves were performed according to ADAMTS7 genotypes for CV mortality. Results showed that 47.3% of patients were heterozygous (AG), 36.5% were homozygous for the wild-type allele (AA) and only 16.2% were homozygous for the GG genotype. During the follow-up period, 109 (9.7%) patients died, 77 (6.8%) of CV causes. Survival analysis showed that AA genotype was an independent risk factor for CV mortality compared with reference genotype GG (HR = 2.7, P = 0.025). At the end of follow-up, the estimated survival probability (K-M) was 89.8% for GG genotype, 82.2% for AG and 72.3% for AA genotype (P = 0.039). Carriage of the mutant G allele of the ADAMTS7 gene was associated with improved CV survival in patients with documented CAD. The native overfunctional ADAMTS7 allele (A) may accelerate VSMC migration and lead to neointimal thickening, atherosclerosis progression and acute plaque events. ADAMTS7 gene should be further explored in CAD for risk prediction, mechanistic and therapeutic goals.


Acta Médica Portuguesa | 2017

Aortic Dissection Mimicking ST Elevation Myocardial Infarction

R. Rodrigues; Nuno Borja Santos; Décio Pereira

the false lumen and no ostia originating from it. Thoracic and abdominal angio-CT scan confirmed type A aortic dissection extending to abdominal aorta and right iliac artery (Fig.s 1C, 1D). Acute type A aortic dissection can be difficult to diagnose and can mimic STEMI.1 Although right coronary artery is more often involved when myocardial infarction is present, this diagnose has to be considered when difficulty is present in selective catheterization of either ostia.2 Aortic Dissection Mimicking ST Elevation Myocardial Infarction


Acta Cardiologica | 2017

Interrupted aortic arch in a 58-year-old patient

R. Rodrigues; André Correia; Bruno Silva; Susana Gomes; Décio Pereira

Received 22 December 2015; revision accepted for publication 8 February 2016. A 58-year-old male patient was evaluated in the cardiology outpatient setting after an episode of hypertension and atrial fibrillation. He was also an ex-smoker. Echocardiogram revealed slight left ventricular dilation with diastolic dysfunction and a systolic function in the lower normality level, as well as a rheumatic valvar disease with moderate mitral stenosis and slight aortic valve involvement, atrial enlargement and pulmonary hypertension. After an episode of acute pulmonary oedema the patient was referred for coronary catheterization. A right femoral approach was attempted and progression of the guidewire was not possible due to an interrupted aortic arch (IAA) (figure 1A), that was confirmed by right radial approach (figure 1B). The coronary arteries had no significant stenosis but the circumflex artery had an anomalous origin. A CT-scan confirmed an interrupted aortic arch (IAA) in the descending aorta, 27 mm below the left subclavian artery, and a short, 15-mm occluded segment Interrupted aortic arch in a 58-year-old patient


Acta Cardiologica | 2017

Unroofed coronary sinus: multi-modality evaluation

R. Rodrigues; Gomes Serrão; Susana Gomes; Décio Pereira

Received 22 December 2015; revision accepted for publication 29 April 2016. A 61-year-old man was referred for mild exercise intolerance. He had a previous history of chronic obstructive pulmonary disease, arterial hypertension and was an ex-smoker. Physical examination revealed a systolic murmur and his electrocardiogram showed sinus rhythm and an incomplete right bundle-branch block. A transthoracic echocardiogram was performed and showed mild left ventricular hypertrophy, mild rheumatic mitro-aortic disease, left atrial (LA) enlargement and dilated right ventricle (figure 1 A-D), dilated coronary sinus (CS) (panel A, small arrow) and a prominent CS flux into right atria (RA) (panel C, D, large arrow). Transoesophageal echocardiography revealed a communication between the LA and the RA through a dilated coronary sinus (panel E, large arrow). A cardiac computed tomography confirmed the diagnosis of an unroofed coronary sinus showing the shunt between LA and RA through a dilated CS (panel F, large arrow). Unroofed coronary sinus: multi-modality evaluation


Acta Cardiologica | 2017

Incomplete Shone’s complex: adult age diagnosis

R. Rodrigues; André Correia; Gomes Serrão; P. Faria; Susana Gomes; Décio Pereira

Received 22 December 2015; revision accepted for publication 13 January 2016. A 25-year-old male with previous history of heart surgery was referred for a control echocardiogram. He had been operated when he was 5 years old for reparation of aortic coarctation and the excision of a subaortic membrane, and was then lost to follow-up. No other changes were detected previously or during surgery. The patient was clinically stable without medication and the physical exam was unremarkable. The echocardiogram showed normal left ventricular function, but bicuspid aortic valve (figure 1 A), conditioning mild aortic stenosis, and a parachute mitral valve (figure 1 B, C) with single papillary muscle (figure 1 D, E – arrow) were present, with slight increase in transmitral velocity and mild regurgitation. No residual coarctation was present. Shone’s complex is a rare congenital heart disease consisting of several levels of left-sided obstructive lesions including supravalvar mitral ring, parachute mitral valve, Incomplete Shone’s complex: adult age diagnosis


Revista Portuguesa De Pneumologia | 2016

Novos «critérios refinados» eletrocardiográficos na avaliação de atletas

R. Rodrigues; Gomes Serrão; Susana Gomes; Décio Pereira

We read the exhaustive review by Machado and Vaz Silva entitled ‘‘Benign and pathological electrocardiographic changes in athletes’’ with great interest. As stated in the article, the Seattle criteria are among the most commonly used tools for assessing the electrocardiogram (ECG) of athletes, in order to detect and differentiate pathological alterations from those related to intense exercise. They have improved the false-positive rate while maintaining diagnostic accuracy in particular populations, compared to the previous recommendations for the interpretation of the ECG in athletes published by the European Society of Cardiology (ESC), initially in 2005 and updated in 2010. However, although the Seattle criteria were the first to address the influence of race, with specific recommendations for individuals of African and Afro-Caribbean origin (who have a higher risk of sudden cardiac death), the false-positive rate remains high, especially in black athletes. This increases the cost of pre-participation screening, besides the consequences of exclusion from competitive sports in terms of the professional and emotional impact on athletes’ lives. Sheikh et al. compared ECG changes between black and white athletes and proposed a set of ‘refined’ criteria which, without losing sensitivity, improved specificity, particularly in black athletes. These new criteria are predicated on the idea that isolated ECG findings of left or right atrial dilatation, left or right axis deviation, and/or right ventricular hypertrophy are of dubious value in athletes without symptoms, family history or abnormalities on physical examination (Table 1). Sheikh et al.’s study


International Journal of Cardiovascular Sciences | 2016

Saved by the x-ray

R. Rodrigues; N. Santos; Susana Gomes; Décio Pereira

Manuscript received on January 12, 2016; revised on June 05, 2016; approved on May 29, 2016. Long QT syndrome; Electrocardiography, ambulatory; Torsades de pointes.


European Heart Journal | 2018

P1685Gene - Environment interactions in the cellular axis of ischemic cardiopathy using machine learning models

Pereira A; R. Palma Dos Reis; R. Rodrigues; Jucemar Monteiro; J A Sousa; A.C. Sousa; Eva Henriques; M. Rodrigues; Graça Guerra; S. Borges; I. Ornelas; A Drumond; Maria Isabel Mendonça


European Heart Journal | 2018

P2513Synergistic association between TCF21 gene variant and smoking

J A Sousa; Maria Isabel Mendonça; Pereira A; R. Rodrigues; Jucemar Monteiro; M. Neto; A.C. Sousa; Eva Henriques; S. Freitas; Ana Isabel Freitas; S. Borges; I. Ornelas; A Drumond; R. Palma Dos Reis


European Heart Journal | 2018

P934Gene-gene interaction in ischemic cardiopathy by MDR: beyond logistic regression

Pereira A; R. Palma Dos Reis; Jucemar Monteiro; J A Sousa; R. Rodrigues; M. Neto; A.C. Sousa; S. Freitas; M. Rodrigues; Ana Isabel Freitas; C. Freitas; I. Ornelas; A Drumond; Maria Isabel Mendonça

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Pereira A

Hospital Pulido Valente

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A.C. Sousa

Instituto de Biologia Molecular e Celular

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S. Gomes

Universidade Federal Rural do Semi-Árido

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M. Rodrigues

Federal University of Paraíba

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Jucemar Monteiro

Universidade Federal do Rio Grande do Sul

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Susana Gomes

Instituto Nacional de Saúde Dr. Ricardo Jorge

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