R. Srinivasa Rao
Indian Institute of Chemical Technology
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Featured researches published by R. Srinivasa Rao.
Tetrahedron Letters | 2001
J. S. Yadav; B. V. Subba Reddy; R. Srinivasa Rao; G Veerendhar; K. Nagaiah
Abstract Aziridines react smoothly with arenes in the presence of a catalytic amount of indium triflate at ambient temperature to afford the corresponding β-aryl amine derivatives in excellent yields with high regioselectivity.
Tetrahedron | 2003
J. S. Yadav; B. V. S. Reddy; J.S.S. Reddy; R. Srinivasa Rao
Room temperature ionic liquids are found to catalyze efficiently the three component-coupling reactions of aldehydes, amines and cyclic enol ethers such as 3,4-dihydro-2H-pyran and 2,3-dihydrofuran under mild and convenient conditions to afford the corresponding pyrano- and furanoquinolines in excellent yields with high endo-selectivity. Interestingly, 2,3-dihydrofuran afforded selectively endo-products under the similar reaction conditions.
Tetrahedron | 2002
J. S. Yadav; B. V. S. Reddy; R. Srinivasa Rao; Ajit C. Kunwar
Indium trichloride catalyzes efficiently the cycloaddition reactions of aryl amines with 3,4-dihydro-2H-pyran (DHP) under mild reaction conditions to afford the corresponding pyrano[3,2-c]quinolines in high yields with high diastereoselectivity.
Tetrahedron Letters | 2002
J. S. Yadav; B. V. S. Reddy; G. Kondaji; R. Srinivasa Rao; S. Praveen Kumar
Abstract Pyrrole and its derivatives react smoothly with acid chlorides and sulfonyl chlorides in the presence of zinc metal in toluene at ambient temperature to afford the corresponding 2-acetyl and 2-sulfonyl pyrrole derivatives in high yields with high regioselectivity.
Bioorganic & Medicinal Chemistry Letters | 2010
K. Nagaiah; Akkaladevi Venkatesham; R. Srinivasa Rao; Venkateshwarlu Saddanapu; J. S. Yadav; Shaik Jeelani Basha; Akella V. S. Sarma; Balasubramanian Sridhar; Anthony Addlagatta
New cis-fused tetrahydrochromeno[4,3-b]quinolines have been synthesized by intramolecular [4+2] imino-Diels-Alder reactions of 2-azadienes derived in situ from aromatic amines and 7-O-prenyl derivatives of 8-formyl-2,3-disubstituted chromenones in the presence of 20mol% Yb(OTf)(3) in acetonitrile under reflux conditions in good to excellent yields. The structures were established by spectroscopic data and further confirmed by X-ray diffraction analysis. These compounds were evaluated for their antiproliferative activity against MDA-MB-231 and MCF-7 breast cancer cells. The results showed that compounds 3e, 3f, and 3k exhibit significant antiproliferative activity against MCF-7 breast cancer cells and low inhibitory activity against MDA-MB-231 breast cancer cell lines. Compound 3h displayed activity as comparable to tamoxifen on both the cell lines.
Bioorganic & Medicinal Chemistry Letters | 2009
P. Srihari; Palash Dutta; R. Srinivasa Rao; J. S. Yadav; S. Chandrasekhar; Pravin Thombare; Jogeswar Mohapatra; Abhijit Chatterjee; Mukul R. Jain
Solvent free multicomponent reaction of Baylis Hillman acetate, TMS azide and arylnitrile to produce 1,5-disubstituted tetrazole is described. Some of these tetrazoles are found to be potential TNF-alpha inhibitors.
MedChemComm | 2012
A. Venkatesham; R. Srinivasa Rao; K. Nagaiah; J. S. Yadav; G. RoopaJones; S. J. Basha; Balasubramanian Sridhar; Anthony Addlagatta
A new series of chromeno-annulated cis-fused pyrano[3,4-c]pyran derivatives have been synthesized by intramolecular [4 + 2] domino Knoevenagel–hetero-Diels–Alder reactions of 1-oxa-1,3-butadienes derived in situ from 1,3-dicarbonyls/active methylenes and 7-O-prenyl derivatives of 8-formyl-2,3-disubstituted chromenones in the presence of 20 mol% ethylenediamine diacetate (EDDA) in acetonitrile under reflux conditions in good to excellent yields. The structures were established based on spectroscopic data, and were further confirmed by X-ray diffraction analysis. These compounds were evaluated for their anti-proliferative activity using an in vitro MTT cytotoxicity assay. The results clearly demonstrated that compounds 4a, 4b, 4c, 4j, 4k, 4l, 4m and 4n exhibited significant anti-proliferative activity against human A549 lung cancer and non-cancer MRC-5 cell lines along with potent inhibitory activity against human neuroblastoma SK-N-SH cancer cell lines. Among these, compounds 4a, 4b and 4j displayed the most potent anti-proliferative activity against human lung cancer A549 cell lines, while 4a and 4b displayed against neuroblastoma SK-N-SH cancer cell lines when compared to the standard doxorubicin.
Synthetic Communications | 2006
K. Nagaiah; V. Naveen Kumar; R. Srinivasa Rao; B. V. S. Reddy; A. V. Narsaiah; J. S. Yadav
Abstract The imines were generated in situ from carbonyl compounds and amines, which undergo smooth reduction with sodium borohydride in an ionic liquid/H2O solvent system. The reaction conditions were very mild and neutral to afford the corresponding highly functionalized amines in excellent yields. IICT Communication No. 041013.
ChemInform | 2008
J. S. Yadav; B. V. Subba Reddy; R. Srinivasa Rao; G. Rajendar
Cycloaddition reactions have found many important synthetic applications in the preparation of biologically important classes of heterocycles. Cycloaddition reactions lead to the formation of new σ-bonds via a cyclic transition state resulting in cyclic products with desired ring size and stereoselectivities. This review collects the synthesis of the most important heterocyclic compounds via cycloadditions under indium catalysis. This review also discusses the mechanistic and stereochemical aspects of these cycloadditions.
Synthetic Communications | 2012
K. Nagaiah; K. V. Purnima; D. Sreenu; S. Jhansi; R. Srinivasa Rao; J. S. Yadav
Abstract β-Enamino derivatives have been synthesized by the condensation of amines and β-dicarbonyl compounds in the presence of 1 mol% of phosphomolybdic acid (PMA) at room temperature in good to excellent yields. GRAPHICAL ABSTRACT