R. W. Payne

Comparison of serum C-reactive protein, glycoprotein and seromucoid in cancer, arthritis, tuberculosis and pregnancy.

Summary and Conclusions C-reactive protein has been found to be present in cancer as well as in acute inflammatory states. In cancer, acute rheumatoid arthritis and active tuberculosis, CRP is significantly corrated with seromucoid. A lesser but significant correlation was found between serum glycoprotein and CRP in these conditions. In pregnancy which was characteristically accompanied by elevated serum glycoprotein and normal seromucoid concentrations, CRP was only occasionally found. This suggests that the elevated serum glycoprotein levels of pregnancy may be due to causes other than inflammation.

Absence of serum albumin associated with rheumatoid arthritis.

Excerpt Albumin is the most abundant serum protein component in the normal human being. This major serum protein component is of obvious importance in providing a major portion of the osmotic press...

Serum Protein and Glycoprotein Alteration in Swine with Experimental Arthritis.

Summary A serial study was made of protein and glycoprotein changes of swine during arthritis which follows recovery from Erysipelothrix infections. As in sera from humans with rheumatoid arthritis, elevated serum glycoprotein, seromucoid and serum globulins and lowered serum albumin concentrations were noted in swine sera during active phases of the disease. No serum α1-globulin was identified in swine sera. During remissions of experimental arthritis, serum glycoprotein levels decreased and the serum albumin increased. Cortisone treatment of animals with active arthritis produced clinical improvement accompanied by striking increases of albumin protein with decreases of seromucoid, serum γ-globulin protein and γ-globulin bound hexose concentrations.

Interactions of Triethylenethiophosphoramide, Estrogen and Gonadotropin On the Ovary of Hypophysectomized Immature Rat.

Summary In the hypophysectomized weanling rat triethylenethiophosphoramide (Thio-TEPA) produced quantitative destruction of granulosa cells and ova. Stimulation of the ovary by pituitary gonadotropin was antagonized by Thio-TEPA, resulting in blocking of luteinization and formation of cystic follicles. Diethylstilbestrol partially protected against destructive effects of Thio-TEPA on the ovary allowing luteinization to proceed. Under all circumstances Thio-TEPA caused a quantitative reduction in ovarian weight over a period of 5 days.