Rachael M. Payne
Johns Hopkins University
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Featured researches published by Rachael M. Payne.
Public Health | 2018
Charalampos Siotos; Z. Ibrahim; J. Bai; Rachael M. Payne; Stella M. Seal; Scott D. Lifchez; A.A. Hyder
OBJECTIVES Hand injuries result in major healthcare costs from lack of productivity and disability. With rapid industrialization, the incidence of hand injuries is expected to rise in low- and middle-income countries (LMICs). However, estimates of burden and validated outcome tools are needed for effective resource allocation in the management of these injuries. STUDY DESIGN We conducted a systematic review to evaluate the burden of hand injuries in LMICs according to Preferred Reporting Items for Systematic Review and Meta-Analyses guidelines. METHODS We searched PubMed, Scopus, Embase, Cochrane Library, PAIS International, African Index Medicus, Global Health, IMMEMR, IMSEAR, Wholis and Bdenf, Lilacs, Scielo, WPRIM, and WHO International Clinical Trials Registry Platform to detect eligible articles with no restrictions on length of follow-up, type of hand injury, or date. RESULTS We included 17 articles after screening 933 eligible articles based on title, abstract, and full-text screening. There was significant heterogeneity and low quality of evidence. All included articles suggest that hand injuries were associated with work limitations for the majority of patients, and residual pain can further limit their activities. Direct and indirect costs related to treatment account for a major healthcare burden with limited evidence on estimates of long-term cost from disability. CONCLUSIONS The present systematic review highlights the paucity of high-quality data on the epidemiology, management, and burden of hand injuries in LMICs. The data are heterogeneous, and comprehensive metrics are lacking. Because hand injuries can account for a significant proportion of injury-related disability, reducing the overall burden of hand injuries is of utmost importance.
Plastic and reconstructive surgery. Global open | 2017
Meredith L. Meyer; Ricardo J. Bello; Charalampos Siotos; Mohamad E. Sebai; Rachael M. Payne; Michele A. Manahan; Justin M. Sacks; Carisa M. Cooney; Gedge D. Rosson
Sarday, M ay 6, 2017 persists until the infection is cleared by antibiotic therapy and/or surgical management. While the acute phase response is essential for tissue healing and regeneration, over-activation of the acute phase response is maladaptive and may lead to systemic complications including thrombosis, organ failure, and disseminated intravascular coagulation. In the setting of severe infections, continuous activation of the APR has the potential to become dysregulated. The magnitude of the acute phase reaction can be quantified by both the peak concentration of CRP as well as the total duration of CRP elevation through calculating the area under the curve. We hypothesize that the area under the CRP curve is increased in musculoskeletal infection due to continual tissue injury and we believe that this cumulative response over time correlates with the incidence of complications.
Plastic and reconstructive surgery. Global open | 2017
Mohamad E. Sebai; Charalampos Siotos; Rachael M. Payne; Stella M. Seal; Mehran Habibi; Kristen P. Broderick; Michele M. Manahan; Gedge D. Rosson
RESULTS: The decision tree shows the associated probabilities, QALYs and costs for each clinical outcome arising from either the LVOS arm or the SSIR arm. An ICUR of
Plastic and reconstructive surgery. Global open | 2017
Mohamad E. Sebai; Charalampos Siotos; Rachael M. Payne; Stella M. Seal; Kristen P. Broderick; Mehran Habibi; Michele A. Manahan; Carisa M. Cooney; Gedge D. Rosson
644/QALY favoring LVOS was calculated based off of its clinical-effectiveness gain of 7.11 QALY at an additional cost of
Plastic and reconstructive surgery. Global open | 2017
Rachael M. Payne; Charalampos Siotos; Michele A. Manahan; Gedge D. Rosson; Carisa M. Cooney
4,579.43 (partly due to the additional costs of radiation treatment and the bilateral operation needed for LVOS compared to no radiation and unilateral surgery for SSIR). This proved that LVOS is a cost-effective surgical option given that a surgical approach is deemed cost-effective if its ICUR is less than
Plastic and Reconstructive Surgery | 2018
Rachael M. Payne; Charalampos Siotos; Michele A. Manahan; Gedge D. Rosson; Carisa M. Cooney
50,000/QALY. One-way sensitivity analyses underscored the degree by which LVOS was costeffective. For example, LVOS became cost-ineffective when a successful LVOS cost more than
Journal of Craniofacial Surgery | 2018
Jamie A. Spitz; Rachael M. Payne; Marco F. Ellis
50,000. Similarly, probabilistic sensitivity analysis using Monte-Carlo simulation showed that even with varying multiple variables at once, results tended to favor our conclusion supporting the costeffectiveness of LVOS.
Plastic and reconstructive surgery. Global open | 2017
Rachael M. Payne; Amy Elizabeth Anderson; Alexis Parrillo; Kaitlyn Sadtler; Iwen Wu; Jeffrey W. Aston; Allison Steiner; Carisa M. Cooney; Damon S. Cooney; Patrick J. Byrne; Drew M. Pardoll; Jennifer H. Elisseeff
PURPOSE: Although numerous publications have described distraction osteogenesis (DO) for craniosynostosis, methods of reporting quantitative results have been inconsistent. Therefore, the efficacy of anterior DO and posterior DO in regards to volume change is not well established. We report a metric that relates volume change to distraction length and our analysis of ICV change by distraction osteogenesis.
Plastic and reconstructive surgery. Global open | 2017
Charalampos Siotos; Ricardo J. Bello; Rachael M. Payne; Mehran Habibi; Kristen P. Broderick; Oluseyi Aliu; Carisa M. Cooney; Gedge D. Rosson
METHODS: A systematic scoping review was undertaken from October 2016 to January 2017, with no restrictions on date or language. We followed the five scoping review steps as proposed by Arskey and O’Malley: (1) Identification of the research question; (2) Identification of relevant studies; (3) Study selection; (4) Data charting and (5) Collation and reporting of results.2 A narrative synthesis of the literature according to themed issues was developed, together with a summary of relevant numeric data.
Plastic and reconstructive surgery. Global open | 2017
Charalampos Siotos; Rachael M. Payne; Scott D. Lifchez; Damon S. Cooney; Gedge D. Rosson; Carisa M. Cooney