Rachel Tomer

Does unilateral dopamine deficit contribute to depression

A system of emotional control of behavior is believed to be lateralized to the right hemisphere. Given that dopaminergic pathways are involved in affective behavior, depression, which is recognized as an integral part of Parkinsons disease, may be associated with a dopamine imbalance. The present study examined this hypothesis in patients with unilateral symptomatology indicating either left hemisphere parkinsonism (LHP) or right hemisphere parkinsonism (RHP). Sixteen patients were tested on a battery of neuropsychological tests and several scales for evaluating mood. The two groups did not differ significantly on either cognitive or emotional measures. However, RHP patients rated themselves higher on the Present Scale of Cantril, and showed some neglect of the left visual field, as compared to LHP patients.

Exposure to amphetamine after substantia nigra lesion interferes with the process of behavioral recovery

Recovery from unilateral substantia nigra lesion may be indicated by re-emergence of circling in the pre-lesion preferred direction. Following 6-OHDA-induced lesion of the dominant SN, we examined: (a) The effect of the delay from lesioning on amphetamine-induced rotation asymmetry, and (b) The effect of early post-lesion exposure to amphetamine on later rotation asymmetry. d-Amphetamine was initially injected either 7, 14, 21, or 30 days after lesioning. Transient circling in pre-lesion preferred direction (contralateral to lesioned side) was more frequently encountered on days 7 and 30 after lesioning, as compared to days 14 and 21. The contralateral rotation observed on day 7 is attributed to degeneration-induced DA release, whereas contralateral rotation noted on day 30 is believed to reflect the operation of post-lesion compensatory processes within the spared DA neurons. In response to subsequent amphetamine administration 30 days after lesioning, rats with previous exposure to the drug circled ipsilaterally, whereas most rats given amphetamine for the first time in that session rotated contralaterally to the lesion. These findings suggest that post-lesion administration of amphetamine interferes with the process of recovery.

Visual evoked potentials in hemiparkinsonism

Abstract Visual evoked potentials (VEPs) were recorded bilaterally from the parietal areas in patients with hemiparkinsonism. VEPs recorded over the hemisphere contralateral to the side of parkinsonian symptomatology showed diminished maximal amplitude of secondary components and increased peak latency of an early positive component (P 100 ). After a period of levodopa treatment symmetry of latencies and reversal of VEP max asymmetry were observed.

Transient contralateral rotation following unilateral substantia nigra lesion reflects susceptibility of the nigrostriatal system to exhaustion by amphetamine

Following unilateral 6-OHDA induced SN lesion, a transient period of contralateral rotation has been reported to precede the predominant ipsilateral circling. In order to clarify the nature of this initial contralateral rotation we examined the effect of the duration of recovery period after the lesion, on amphetamine-induced rotational behavior. Three days post lesion, most rats circled predominantly contralaterally to the lesion. Such contralateral rotation may result from either degeneration-induced breakdown of the DA pool, or lesion-induced increase of DA turnover in the spared neurons. A substantial degree of contralateral preference was still evident when amphetamine was administered for the first time 24 days after lesioning, indicating involvement of spared cells in the contralateral rotation. However, regardless of the duration of recovery (and irrespective of either lesion volume, amphetamine dose, or post-lesion motor exercise), amphetamine-induced rotation tended to become gradually more ipsilateral as the observation session progressed, and all rats circled ipsilaterally to the lesion in response to further amphetamine injections. These findings suggest that amphetamine has an irreversible effect on the post-lesion DA pool contributing to contralateral rotation.

Left hemisphere hyperactivity in schizophrenia: Abnormality inherent to psychosis or neuroleptic side-effects?

Studies measuring reflective lateral eye movements (LEM) in schizophrenic patients revealed predominance of rightward LEMs, which was interpreted as suggesting left hemisphere overactivation in schizophrenia. In the present study LEM behaviour of medicated schizophrenics was compared to that of non-medicated patients. Rightward LEMs were predominant in a group of patients treated with phenothiazines with piperazine side chains, whereas among schizophrenics treated with non-piperazine drugs leftward LEMs were more predominant. This finding suggests that previous reports on LEM directionality in schizophrenia may have been confounded by neuroleptic medication. The possible effect of piperazine derivatives on hemispheric balance is discussed.

Reactive gaze laterality in schizophrenic patients

Reflective lateral eye movements (LEMs) in response to questions of different categories are indicative of differential hemispheric reactivity. These LEMs were studied in schizophrenic patients and normal subjects, in response to 24 questions (12 visual-emotional and 12 verbal-neutral). Two categories of saccades were observed: short-latency LEMs (S-LEMs) and long-latency LEMs (L-LEMs). S-LEMs are believed to be associated with orienting response mechanism. L-LEMs are considered to be related to decision-making or formulating hemispheric-activity-dependent response strategy. In the present study, a general trend of leftward LEMs was found among normals regardless of the questions category, whereas schizophrenics tended to show predominantly rightward LEMs. This suggests that individual cognitive style, rather than task variables, affects LEM direction. The two types of LEMs and their different involvement in hemispheric activity are discussed.

Hemisphere laterality and smooth pursuit in normal individuals.

34 right-handed women of college age who consistently responded with leftward (“left-movers”) or rightward (“right-movers”) reflective lateral eye movements were tested on spatial and non-spatial syllogisms while engaged in an eye-tracking task. Contrary to expectation, no interaction between tracking direction and syllogism type was observed. Left-movers performed better on all tasks. The results are discussed in relation to hemispheric asymmetry.