Rajanikant Kurane

Synergistic catalysis by an aerogel supported ionic liquid phase (ASILP) in the synthesis of 1,5-benzodiazepines

An ionic liquid film of [Bmim]Cl containing an organometallic catalyst (Cp2ZrCl2) has been anchored on the porous matrix of an aerogel by adsorption interactions. The synthesized aerogel supported ionic liquid phase catalyst was successfully employed in the synthesis of medicinally relevant 1,5-benzodiazepines.

Remarkable anti-breast cancer activity of ferrocene tagged multi-functionalized 1,4-dihydropyrimidines.

A novel series of ferrocene tagged multi-functionalized 1,4-dihydropyrimidines is synthesized by base catalyzed cyclocondensation between ferrocenyl chalcones and amidines. The structures of synthesized compounds were established on the basis of (1)H NMR, (13)C NMR, FTIR spectroscopy as well as by mass spectrometry. The compounds were evaluated for in vitro anticancer activity. The most active compounds from the series displayed GI50 value equal to doxorubicin against the strain of human breast cancer cell line MDA-MB-435.

An expedient synthesis of oxazolones using a cellulose supported ionic liquid phase catalyst

A novel cellulose supported ionic liquid phase catalyst containing hydroxide ions ([CellFemImi]OH) has been synthesized by covalent anchoring of 1-N-ferrocenylmethyl imidazole in the functionalized cellulose matrix followed by an anion metathesis reaction. The [CellFemImi]OH was characterized by various techniques including FT-IR, FT-Raman, 13C solid state NMR, X-ray diffraction, energy dispersive X-ray (EDX) analysis, field emission scanning electron microscopy (FESEM) and thermogravimetric analysis. The [CellFemImi]OH was effectively employed as a heterogeneous catalyst in the synthesis of oxazolones by cyclocondensation of aryl aldehydes with hippuric acid in the presence of acetic anhydride.

Potentially antibreast cancer enamidines via azide–alkyne–amine coupling and their molecular docking studies

An attempt to prepare a new triazole series by Cu catalyzed multicomponent reactions of tosyl azide, propargyl bromide and secondary amines led to the synthesis of enamidines. All the synthesized enamidines were evaluated for antiproliferative activities. The four molecules 4a–c and 4h showed higher anticancer activity with GI50 values less than the standard drug doxorubicin against human breast cancer cell line MCF-7. The virtual analysis ascertains the mode of action of these compounds via inhibition of human cell division protein kinase7 (CDK7).

Intermolecular C–O Coupling Using Hemicucurbituril Supported Ionic Liquid Phase Catalyst

Hemicucurbituril supported ionic liquid phase catalyst (HmCucSILP) has been synthesized by anchoring multilayer of ionic liquid ([Bmim]Cl) containing Pd(OAc)2 and X-phos on the surface of hemicucurbit[6]uril. The HmCucSILP was effectively employed in intermolecular C–O coupling of aryl halides with sodium alkoxides for the synthesis of alkyl aryl ethers.Graphical Abstract

Selective oxidation of alcohols using ferrocene-labeled Merrifield resin-supported ionic liquid phase catalysts

A novel ferrocene-labeled Merrifield resin-supported ionic liquid phase catalysts has been synthesized and successfully utilized for the selective oxidation of primary alcohols into corresponding aldehydes. The catalysts were recovered by simple filtration which greatly simplified the purification step and allowed successive reuse for multiple times without significant loss in activity.Graphical Abstract