Rajeev Ramchand

Disparate prevalence estimates of PTSD among service members who served in Iraq and Afghanistan: Possible explanations

The authors reviewed 29 studies that provide prevalence estimates of posttraumatic stress disorder (PTSD) among service members previously deployed to Operations Enduring and Iraqi Freedom and their non-U.S. military counterparts. Studies vary widely, particularly in their representativeness and the way PTSD is defined. Among previously deployed personnel not seeking treatment, most prevalence estimates range from 5 to 20%. Prevalence estimates are generally higher among those seeking treatment: As many as 50% of veterans seeking treatment screen positive for PTSD, though much fewer receive a PTSD diagnosis. Combat exposure is the only correlate consistently associated with PTSD. When evaluating PTSD prevalence estimates among this population, researchers and policymakers should carefully consider the method used to define PTSD and the population the study sample represents.

How Criminal System Racial Disparities May Translate into Health Disparities

Disadvantaged racial and ethnic minorities in the U.S. are strikingly over-represented in the juvenile justice and adult criminal justice systems. This paper briefly reviews the extent of over-representation attributable primarily to drug offenses and an earlier conceptual framework introduced by Iguchi and colleagues showing how the use of incarceration as a key drug control tool has disproportionately affected the health and well being of racial and ethnic minority communities. We then provide observations from the field that demonstrate how the implementation of a quality assessment approach might be used to mitigate procedural/structural biases that contribute to disparities in minority confinement, and ultimately, to reduce disparities in access to resources and health care.

Prevalence of, risk factors for, and consequences of posttraumatic stress disorder and other mental health problems in military populations deployed to Iraq and Afghanistan

This review summarizes the epidemiology of posttraumatic stress disorder (PTSD) and related mental health problems among persons who served in the armed forces during the Iraq and Afghanistan conflicts, as reflected in the literature published between 2009 and 2014. One-hundred and sixteen research studies are reviewed, most of which are among non-treatment-seeking US service members or treatment-seeking US veterans. Evidence is provided for demographic, military, and deployment-related risk factors for PTSD, though most derive from cross-sectional studies and few control for combat exposure, which is a primary risk factor for mental health problems in this cohort. Evidence is also provided linking PTSD with outcomes in the following domains: physical health, suicide, housing and homelessness, employment and economic well-being, social well-being, and aggression, violence, and criminality. Also included is evidence about the prevalence of mental health service use in this cohort. In many instances, the current suite of studies replicates findings observed in civilian samples, but new findings emerge of relevance to both military and civilian populations, such as the link between PTSD and suicide. Future research should make effort to control for combat exposure and use longitudinal study designs; promising areas for investigation are in non-treatment-seeking samples of US veterans and the role of social support in preventing or mitigating mental health problems in this group.

Posttraumatic Distress and Physical Functioning: A Longitudinal Study of Injured Survivors of Community Violence

This study examines the cross-lagged relationships between posttraumatic distress symptoms and physical functioning, using a sample of 413 persons who were hospitalized for injuries resulting from community violence. Posttraumatic distress was assessed at 1 week, 3 months, and 12 months postinjury, and posttraumatic physical functioning was assessed at 3 months and 12 months. Structural equation modeling was used to assess the prospective relationship between posttraumatic distress symptoms and physical functioning while controlling for demographic characteristics and objective measures of injury severity. Results indicate that posttraumatic distress and physical functioning are reciprocally related. Individuals with high levels of psychological distress at 1 week posttrauma have worse physical functioning at 3 months. Psychological distress at 3 months was not significantly associated with subsequent change in physical functioning at 12 months. Individuals with poor physical functioning at 3 months had higher than expected levels of psychological distress at 12 months. These findings demonstrate a reciprocal relationship between physical and mental health following traumatic injury. Interventions targeting physical recovery may influence subsequent mental health, and therapies aimed at improving early mental health may also have long-term benefits for physical recovery.

Alcohol abuse and illegal drug use among Los Angeles County trauma patients: Prevalence and evaluation of single item screener

BACKGROUND The misuse of alcohol and illicit drugs is implicated with injury and repeat injury. Admission to a trauma center provides an opportunity to identify patients with substance use problems and initiate intervention and prevention strategies. To facilitate the identification of trauma patients with substance use problems, we studied alcohol abuse and illegal substance use patterns in a large cohort of urban trauma patients, identified correlates of alcohol abuse, and assessed the utility of a single item binge-drinking screener for identifying patients with past 12-month substance use problems. METHODS Between February 2004 and August 2006, 677 patients from four large trauma centers in Los Angeles County were interviewed. The sample was broadly representative of the entire Los Angeles County trauma center patient population. RESULTS Twenty-four percent of patients met criteria for alcohol abuse and 15% reported using an illegal drug other than marijuana in the past 12 months. Male gender, assaultive injury, peritrauma substance use, and history of binge drinking were prominent risk factors. A single item binge drinking screen correctly identified alcohol abuse status in 76% of all patients; the screen also performed moderately well in discriminating between those who had or had not used illegal drugs in the past 12 months, with sensitivity estimates reaching 0.79 and specificity estimates reaching 0.74. CONCLUSIONS A large proportion of urban trauma patients abuse alcohol and use illegal drugs. Distinct sociodemographic and substance use history may indicate underlying risky behaviors. Interventions and injury prevention programs need to address these causal behaviors to reduce injury morbidity and recidivism. In the busy trauma care setting, a one-item screener could be helpful in identifying patients who would benefit from more thorough assessment and possible brief intervention.

Seven-Year Life Outcomes of Adolescent Offenders in Los Angeles

OBJECTIVES We examined important life outcomes for adolescent offenders to describe how they were faring in young adulthood. METHODS We assessed 449 adolescent offenders (aged 13-17 years) in Los Angeles, CA, whose cases had been adjudicated by the Los Angeles Superior Court and who had been referred to group homes between February 1999 and May 2000. We used the Global Appraisal of Individual Needs to interview respondents at baseline and at 3, 6, 12, 72, and 87 months after baseline. A total of 395 respondents (88%) were interviewed or confirmed as dead at the final interview. RESULTS At final interview, 12 respondents had died, 7 of them from gunshot wounds. Thirty-six percent of respondents reported recent hard drug use, and 27% reported 5 or more symptoms of substance dependence. Sixty-six percent reported committing an illegal activity within the previous year, 37% reported being arrested within the previous year, and 25% reported being in jail or prison every day for the previous 90 days. Fifty-eight percent had completed high school or obtained a GED, and 63% reported working at a job in the previous year. CONCLUSIONS The high rates of negative life outcomes presented here suggest the need for more effective rehabilitation programs for juvenile offenders.

Prevalence and Correlates of Drinking Behaviors of Previously Deployed Military Personnel and Matched Civilian Population.

We examined drinking behaviors (frequency of use, quantity of use, and frequency of binge drinking) and correlates of frequency of use and binge drinking in a representative sample of previously deployed personnel from the U.S. military (n = 1,887). Drinking behaviors were compared with a matched sample of adults in U.S. households (n = 17,533). Comparable patterns of alcohol consumption were reported in both samples: 70% of previously deployed personnel and 69% of U.S. adults reported drinking alcohol in the past 30 days, though civilians drank on average more drinks on the days that they drank than did previously deployed military personnel. Regression analyses indicated that, among previously deployed military personnel, deployment-related experiences (e.g., combat-related traumas) and psychological distress (e.g., symptoms associated with posttraumatic stress disorder) were associated with frequency of drinking behaviors. We discuss the implication of our findings for developing interventions to modify drinking behaviors for military personnel.

The effectiveness of community-based delivery of an evidence-based treatment for adolescent substance use

This study evaluates the effectiveness of motivational enhancement therapy/cognitive behavioral therapy-5 (MET/CBT-5) when delivered in community practice settings relative to standard community-based adolescent treatment. A quasi-experimental strategy was used to adjust for pretreatment differences between the MET/CBT-5 sample (n = 2,293) and those who received standard care (n = 458). Results suggest that youth who received MET/CBT-5 fared better than comparable youth in the control group on five of six 12-month outcomes. A low follow-up rate (54%) in the MET/CBT-5 sample raised concerns about nonresponse bias in the treatment effect estimates. Sensitivity analyses suggest that although modest differences in outcomes between the MET/CBT-5 nonrespondents and respondents would yield no significant differences between the two groups on two of the six outcomes, very large differences in outcomes between responders and nonresponders would be required for youth receiving MET/CBT-5 to have fared better had they received standard outpatient care.

Subgroups Analysis when Treatment and Moderators are Time-varying

Prevention scientists are often interested in understanding characteristics of participants that are predictive of treatment effects because these characteristics can be used to inform the types of individuals who benefit more or less from treatment or prevention programs. Often, effect moderation questions are examined using subgroups analysis or, equivalently, using covariate × treatment interactions in the context of regression analysis. This article focuses on conceptualizing and examining causal effect moderation in longitudinal settings in which both treatment and the putative moderators are time-varying. Studying effect moderation in the time-varying setting helps identify which individuals will benefit more or less from additional treatment services on the basis of both individual characteristics and their evolving outcomes, symptoms, severity, and need. Examining effect moderation in these longitudinal settings, however, is difficult because moderators of future treatment may themselves be affected by prior treatment (for example, future moderators may be mediators of prior treatment). This article introduces moderated intermediate causal effects in the time-varying setting, describes how they are part of Robins’ Structural Nested Mean Model, discusses two problems with using a traditional regression approach to estimate these effects, and describes a new approach (a two-stage regression estimator) to estimate these effects. The methodology is illustrated using longitudinal data to examine the time-varying effects of receiving community-based substance abuse treatment as a function of time-varying severity (or need).

Associations Between Abstinence in Adolescence and Economic and Educational Outcomes Seven Years Later Among High-Risk Youth

AIM In this study, we investigated the relationship between abstinence and long-term educational and economic outcomes among a sample of high-risk youth. METHODS Multivariable regression models were used to estimate associations between abstinence and outcomes among a sample of 13-17 year-olds referred to group homes in Los Angeles in 1999-2000 and followed for 87 months afterwards. Abstinence was measured during the first year of the study. We considered differential effects based on the duration of abstinence (12 vs. 6 months) and type of abstinence (all substances vs. use of alcohol and/or marijuana) on three 87-month outcomes: having received a high-school diploma or equivalent by age 20, institutionalization in the past 90 days, and total legitimate income for the past 90 days. RESULTS Abstinence from all substances for 12 months was associated with positive long-term educational and economic outcomes relative to using any drug during the same time interval. Abstaining from all substances for 12 months was also associated with an increased likelihood of being a legitimate wage earner and decreased likelihood of being institutionalized relative to using only alcohol and/or marijuana during that time interval. No effect on long-term outcomes was seen among youth who abstained for only 6 months relative to those who used drugs during this interval, or for youth who used only alcohol and/or marijuana over 12 months vs. those who used other drugs during this interval. CONCLUSIONS The results presented here justify continued and expanded efforts to promote long periods of abstinence from all drugs for high-risk youth.