Rajput Mc

Acute Insulin Response to Glucagon, Tolbutamide, and Glucose in Non-insulin-dependent Diabetes of the Young

Acute insulin release in response to maximal intravenous doses of glucose (0.5 g/kg), tolbutamide (1 g), and glucagon (1 mg) was studied in 10 subjects with non-insulin-dependent diabetes of the young (NIDDY) and 10 age-, sex-, and weight-matched controls. Diabetic subjects had attenuated insulinemic responses to all three stimuli, in comparison with control subjects. However, insulin responses to glucagon and tolbutamide were higher than those obtained with intravenous glucose. This study demonstrates that the pancreatic β-cell is more responsive to nonglucose secretagogues than to glucose stimuli in individuals with NIDDY.

Nephropathy in Indian Patients with Non-insulin-dependent Diabetes in the Young

In 85 patients diagnosed as having non-insulin-dependent diabetes in the young (NIDDY), 6 were found to have nephropathy. The duration of diabetes ranged from 2 to 17 yr; 5 of the 6 patients had retinopathy as evidenced by fluoroscein angiography (3 with proliferative changes). All 6 patients had a 24-h urinary protein excretion >0.5 g and a glomerular filtration rate <80 ml/min. Serum β2-microglobulin levels were increased in all 6 patients, while only 3 had increased serum creatinine levels.