Ralph M. Myerson

SARCOIDOSIS WITH VERTEBRAL INVOLVEMENT

Excerpt The protean manifestations of sarcoidosis are well known. Involvement of practically every organ and system of the body, including the bones, has been well documented. Vertebral sarcoidosis...

LÖFFLER'S SYNDROME: REPORT OF A CASE ASSOCIATED WITH ADMINISTRATION OF MEPHENESIN CARBAMATE (TOLSERAM)

Excerpt In 1932 and 1936 Loffler1, 2described a syndrome, commonly associated with his name, characterized by transitory pulmonary infiltrations that are often migratory, eosinophilia, and a benign...

Xanthomatous Biliary Cirrhosis Following Chlorpromazine

Abstract A case of chlorpromazine-induced jaundice, progressing to a chronic hepatic disorder characterized by a marked disturbance of lipid metabolism, with formation of xanthomas and resembling xanthomatous biliary cirrhosis, is presented. Markedly elevated levels of prothrombin, proconvertin and proaccelerin were also present.

Erythrocytosis associated with hepatocellular carcinoma

Abstract The development of erythrocytosis in a patient with hepatocellular carcinoma is reported. There was no demonstrable evidence of increased erythropoietic activity in the patients serum, the hepatic tumor or in the normal liver tissue. The cause for the erythrocytosis remains unexplained.

Deposition of C14-Labelled Cholesterol in the Atheromatous Aorta.

Summary The results suggest that circulating cholesterol exchanges with available cholesterol pools of intima of human aorta. This exchange is slow. Cholesterol in the atheromatous plaques appears to exchange or accept circulatory cholesterol with the greatest difficulty. The highest exchange or depositions were observed for area of the arch of human aorta; abdominal part of aorta showed a smaller exchange. The media showed about the same cholesterol rate of exchange through length of aorta. A disk technic suitable for various types of quantitative assays of intima, media, etc. of the aorta was described.

HYPERPARATHYROIDISM ASSOCIATED WITH PAGET'S DISEASE

Excerpt The clinical, biochemical, radiologic, and histopathologic findings of hyperparathyroidism are sufficiently characteristic in the majority of instances to allow the diagnosis to be made wit...

The effect of L-triiodothyronine on the fatty acidcomposition of human adipose tissue

Biopsies of subcutaneous fat were analyzed for lipid composition before and after the administration of L-triiodothyronine in 6 obese patients. A slight decrease in total lipids occurred but there were insignificant changes in the fatty acid composition. The study demonstrates the striking constancy of the fatty acid composition of human adipose tissue and its resistance to change.

Hepatocellular carcinoma, positive Australia (hepatitis-associated) antigen and sarcoidosis

Hepatocellular carcinoma usually develops in patients with coarse or macronodular cirrhosis, which in turn is usually considered to be a consequence of viral hepatitis. To explore the relationship between hepatitis and primary carcinoma of the liver, several groups have investigated the incidence of Australia antigen (AU-1) or hepatitis-associated antigen (HAA) in patients with hepatocellular carcinoma. The data have not been consistent. A high frequency of Australia antigen has been reported in series from Greece (1, 2), Uganda (3, 4), and Senegal (4). There are conflicting reports from this country (4-7). This is a report of hepatocellular carcinoma and Australia antigen occurring in an American-born Negro. The case is of added interest because of the presence of long-standing, multisystem sarcoidosis.

Lidocaine-cimetidine Interaction

Excerpt To the editor: Knapp and associates (1) recently reported 15 patients who were treated with cimetidine and lidocaine concomitantly, and the authors concluded that there was an interaction b...

Detection of deconjugation of bile salts by measurement of the specific activity of 14CO2 in expired air

Abstract:Procedures currently available to detect bile acid deconjugation are technically difficult and are not routinely performed in clinical practice. We have assessed bile acid deconjugation by measuring 14CO2 specific activity of breath samples taken at intervals following the oral administration of 1-14C glycocholic acid and of 1-14C taurocholic acid. The test is based on the fact that during deconjugation, the amino acid and cholic acid moieties are split and the labeled carbon is converted to 14CO2 and exhaled. Controls and a number of patients with various malabsorption syndromes have been studied. Included were patients with bacterial overgrowth syndromes, ileal bypass, gastrocolic fistula, regional ileitis, cirrhosis of the liver, and chronic pancreatitis. The results indicate that breath analysis provides a simple, inexpensive and reliable screening technique for the detection of bile acid deconjugation.