Ralph Vaughan Williams

A Constitutive Model for the Inelastic Multiaxial Response of Rene’ 80 at 871C and 982C

This paper contains an extension of the uniaxial state variable constitutive model of Ramaswamy et al. (1988) to the case of multiaxial loading. The correlation between uniaxial and multiaxial loading conditions is achieved through the assumptions of material isotropy and conservation of inelastic volume. The multiaxial extension is based only on the material parameters evaluated from uniaxial loading. The research is accompanied by a multiaxial experimental program to evaluate the response of Rene 80 at 871 C and 982 C. Experiments in the program include torsion, proportional axial and torsion, and nonproportional loading. It was shown experimentally that there is no extra hardening from the multiaxial loading than results from uniaxial loading. Further, it is shown that the multiaxial model is successful in predicting the experimental results using only the parameters determined from the uniaxial experiments.

Molecular Variation at the HLA-A, B, C, DRB1, DQA1, and DQB1 Loci in Full Heritage American Indians in Arizona: Private Haplotypes and Their Evolution

A sample of 492 full heritage, unrelated residents of the Gila River Indian Community (GRIC) of Arizona were characterized for their high-resolution DNA alleles at the HLA-A, B, C, DRB1, DQA1, and DQB1 loci. Only five allelic categories are found at HLA-A, 10 at HLA-B, 8 at HLA-C and HLA-DR, and 4 at DQA1 and DQB1. There is little evidence for population structure at the 6 loci. Two private alleles, B*5102 and B*4005, which are found nearly exclusively in American Indian populations in the desert southwest and northern Mexico, are likely new mutations after the first inhabitation of the area, the evolution of which are reflected in the contemporary distribution of their respective haplotypes. DRB1*1402 has the highest reported frequency of any specificity at the DRB1 locus, 0.7461, and serves as a sensitive probe for locating related east Asian populations. The haplotypes in this population also exhibit a highly restricted distribution and strong genetic disequilibria, which has important implications for matching solid organ and bone marrow allografts. It is shown that, when one considers HLA-A-B-DRB1 homozygotes as allograft donors for all full heritage members of the GRIC, 50% of the community would find a non-mismatched organ within the homozygotes for the six most common haplotypes. This raises questions about transplantation policy and whether, in the presence of high-frequency private alleles and a restricted number of haplotypes, the full heritage American Indian community of the desert southwest should act as its own pool of donors for its affected members.