Ramesh Chandra Malhotra
Defence Research and Development Establishment
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Publication
Featured researches published by Ramesh Chandra Malhotra.
Journal of Chemical Research-s | 2005
Pradeep Kumar Gupta; Kumaran Ganesan; Ambuja Pande; Ramesh Chandra Malhotra
Fentanyl, N-(1-phenethyl-4-piperidyl) propionanilide, was prepared by performing three successive one pot reactions at room temparature.
Drug and Chemical Toxicology | 2009
Laxmi Manral; Natrajan Muniappan; Pradeep Kumar Gupta; Kumaran Ganesan; Ramesh Chandra Malhotra; R. Vijayaraghavan
The breathing pattern of mice that were exposed to fentanyl aerosol was studied (2.7, 5.7, 6.0, 10.0, and 23.6 μg/m3; for 1 hour), using dimethyl sulfoxide as a vehicle. This study was conducted in a head-only exposure assembly. Body plethysmographs connected to a volumetric pressure transducer were used to capture the respiratory signals, and an on-line computer program capable of recognizing the changes in the breathing pattern was used for monitoring the respiratory pattern. The response of mice to fentanyl exposure was found to be concentration dependent. A lower concentration (2.7 μg/m3) showed fast recovery and no mortality, while 100% mortality was observed at a higher concentration (23.6 μg/m3). No sensory, pulmonary irritation, and airway limitation in mice was observed, and death occurred probably due to respiratory depression. The concentration that decreased 50% of the respiratory frequency (RD50) was estimated to be 6.4 μg/m3. The extrapolated human threshold limit value, calculated from the RD50 value, was found to be 0.192 μg/m3. The concentration that caused 50% mortality in exposed mice (LC50) was estimated to be 8.8 μg/m3. This study shows that aerosolized fentanyl does not cause sensory and pulmonary irritation, and since the RD50 and LC50 are very close with a low safety margin, this type of sedative should not be used as an incapacitating agent.
Journal of Sulfur Chemistry | 2005
Kumaran Ganesan; Ramesh Chandra Malhotra; K. Sekhar
Reaction of elemental sulfur in ethylenediamine with 1,1-thiobis(2-chloroethane) or sulfur mustard, the potent chemical warfare agent has been studied. The optimum conditions for the reaction are established for the complete conversion of sulfur mustard into non-toxic products. The above reaction has been successfully converted into a technology for chemical destruction of sulfur mustard (patented in USA, Russia, Germany and India).
Australian Journal of Entomology | 2006
Kumaran Ganesan; M. J. Mendki; M.V.S. Suryanarayana; Shri Prakash; Ramesh Chandra Malhotra
Organic Process Research & Development | 2005
Ambuja Pande; Kumaran Ganesan; Asheesh Kumar Jain; and Pradeep Kumar Gupta; Ramesh Chandra Malhotra
Journal of The Korean Chemical Society | 2007
Suman Awasthi; Poonam Rishishwar; Ambati Narasimha Rao; Kumaran Ganesan; Ramesh Chandra Malhotra
Defence Science Journal | 2007
Asheesh Kumar Jain; Pradeep Kumar Gupta; Kumaran Ganesan; Ambuja Pande; Ramesh Chandra Malhotra
Journal of Thermal Analysis and Calorimetry | 2009
Laxmi Manral; Pradeep Kumar Gupta; M.V.S. Suryanarayana; Kumaran Ganesan; Ramesh Chandra Malhotra
Journal of Heterocyclic Chemistry | 2005
Asheesh Kumar Jain; Pradeep Kumar Gupta; Kumaran Ganesan; Ambuja Pande; Deepak Pardasani; Ramesh Chandra Malhotra
Archive | 2009
Pradeep Kumar Gupta; Laxmi Manral; Kumaran Ganesan; Ramesh Chandra Malhotra; K. Sekhar