Randy K. Kalkman

Pitch Comparisons between Electrical Stimulation of a Cochlear Implant and Acoustic Stimuli Presented to a Normal-hearing Contralateral Ear

Four cochlear implant users, having normal hearing in the unimplanted ear, compared the pitches of electrical and acoustic stimuli presented to the two ears. Comparisons were between 1,031-pps pulse trains and pure tones or between 12 and 25-pps electric pulse trains and bandpass-filtered acoustic pulse trains of the same rate. Three methods—pitch adjustment, constant stimuli, and interleaved adaptive procedures—were used. For all methods, we showed that the results can be strongly influenced by non-sensory biases arising from the range of acoustic stimuli presented, and proposed a series of checks that should be made to alert the experimenter to those biases. We then showed that the results of comparisons that survived these checks do not deviate consistently from the predictions of a widely-used cochlear frequency-to-place formula or of a computational cochlear model. We also demonstrate that substantial range effects occur with other widely used experimental methods, even for normal-hearing listeners.

Simultaneous and non-simultaneous dual electrode stimulation in cochlear implants: evidence for two neural response modalities

Conclusion: There are two modalities of dual electrode stimulation: a shifting, continuous excitation, which is the desired effect, and a split excitation with considerable variation in loudness. The first one most likely occurs in the basal turn, with adjacent contacts, stimulated simultaneously rather than sequentially. Objectives: This study examines the effects on place pitch and loudness of simultaneous current steering and sequential stimulation. These can give cochlear implant patients access to more perceptual channels than physical contacts in the electrode array. Materials and methods: For both lateral wall and perimodiolar electrodes, simultaneous current steering as well as sequential stimulation, place pitch and loudness of the percept were predicted with a computational model of the implanted human cochlea. The loudness predictions were validated with psychophysical loudness balancing experiments. Results: Simultaneous stimulation with adjacent electrode contacts in the basal end of the cochlea was generally able to produce a single, gradually shifting intermediate pitch percept. Simultaneous stimulation beyond the first cochlear turn, sequential stimulation and simultaneous stimulation with non-adjacent electrode contacts often produced two regions of excitation. In the case of sequential stimulation the total amount of current to reach most comfortable loudness was raised, both in the model and in the patients.

Place pitch versus electrode location in a realistic computational model of the implanted human cochlea.

Place pitch was investigated in a computational model of the implanted human cochlea containing nerve fibres with realistic trajectories that take the variable distance between the organ of Corti and spiral ganglion into account. The model was further updated from previous studies by including fluid compartments in the modiolus and updating the electrical conductivity values of (temporal) bone and the modiolus, based on clinical data. Four different cochlear geometries are used, modelled with both lateral and perimodiolar implants, and their neural excitation patterns were examined for nerve fibres modelled with and without peripheral processes. Additionally, equations were derived from the model geometries that describe Greenwoods frequency map as a function of cochlear angle at the basilar membrane as well as at the spiral ganglion. The main findings are: (I) in the first (basal) turn of the cochlea, cochlear implant induced pitch can be predicted fairly well using the Greenwood function. (II) Beyond the first turn this pitch becomes increasingly unpredictable, greatly dependent on stimulus level, state of the cochlear neurons and the electrodes distance from the modiolus. (III) After the first turn cochlear implant induced pitch decreases as stimulus level increases, but the pitch does not reach values expected from direct spiral ganglion stimulation unless the peripheral processes are missing. (IV) Electrode contacts near the end of the spiral ganglion or deeper elicit very unpredictable pitch, with broad frequency ranges that strongly overlap with those of neighbouring contacts. (V) The characteristic place pitch for stimulation at either the organ of Corti or the spiral ganglion can be described as a function of cochlear angle by the equations presented in this paper.

Current focussing in cochlear implants: An analysis of neural recruitment in a computational model

Several multipolar current focussing strategies are examined in a computational model of the implanted human cochlea. The model includes a realistic spatial distribution of cell bodies of the auditory neurons throughout Rosenthals canal. Simulations are performed of monopolar, (partial) tripolar and phased array stimulation. Excitation patterns, estimated thresholds, electrical dynamic range, excitation density and neural recruitment curves are determined and compared. The main findings are: (I) Current focussing requires electrical field interaction to induce spatially restricted excitation patterns. For perimodiolar electrodes the distance to the neurons is too small to have sufficient electrical field interaction, which results in neural excitation near non-centre contacts. (II) Current focussing only produces spatially restricted excitation patterns when there is little or no excitation occurring in the peripheral processes, either because of geometrical factors or due to neural degeneration. (III) The model predicts that neural recruitment with electrical stimulation is a three-dimensional process; regions of excitation not only expand in apical and basal directions, but also by penetrating deeper into the spiral ganglion. (IV) At equal loudness certain differences between the spatial excitation patterns of various multipoles cannot be simulated in a model containing linearly aligned neurons of identical morphology. Introducing a form of variability in the neurons, such as the spatial distribution of cell bodies in the spiral ganglion used in this study, is therefore essential in the modelling of spread of excitation. This article is part of a Special Issue entitled .

Stimulation of the facial nerve by intracochlear electrodes in otosclerosis: a computer modeling study.

Hypothesis: The increased likelihood of facial nerve stimulation (FNS) with cochlear implantation in advanced cochlear otosclerosis is due to a lowering of the facial nerve excitation threshold with increasing bone demineralization. Background: Facial nerve stimulation can complicate cochlear implant fitting, often necessitating the deactivation of certain electrode contacts. Methods: High-resolution computed tomographic scans were used to estimate anatomic features of the cochlea and the facial nerve canal. These features were added to a detailed computational model of the implanted human cochlea to examine the consequences of increased conductivity of the bone of the otic capsule. The model took into account the electrode contact type (banded or otherwise) and position (perimodiolar or lateral wall) of the electrode array. Results: Contrary to the hypothesis, facial nerve thresholds were found to be slightly elevated with increased conductivity of the surrounding bone. However, the threshold and most comfortable loudness levels of the auditory nerve increase more rapidly owing to the reduced current density in the scala tympani as current leaks more easily out of the cochlea. Lateral wall electrodes were predicted to result in an increased likelihood of FNS. A progressively reduced probability of FNS was indicated for the full-band, half-band, and plated electrode arrays, respectively. Conclusion: The clinical observation of increased FNS in cases of cochlear otosclerosis has been demonstrated in a computational model. Rather than decreased FN threshold, it is the increased levels for cochlear stimulation that is the main factor. Particularly, perimodiolar designs with more shielding against lateral spread of current could reduce the likelihood of FNS.

Stimulation strategies and electrode design in computational models of the electrically stimulated cochlea: An overview of existing literature.

ABSTRACT Since the 1970s, computational modeling has been used to investigate the fundamental mechanisms of cochlear implant stimulation. Lumped parameter models and analytical models have been used to simulate cochlear potentials, as well as three-dimensional volume conduction models based on the Finite Difference, Finite Element, and Boundary Element methods. Additionally, in order to simulate neural responses, several of these cochlear models have been combined with nerve models, which were either simple activation functions or active nerve fiber models of the cochlear auditory neurons. This review paper will present an overview of the ways in which these computational models have been employed to study different stimulation strategies and electrode designs. Research into stimulation strategies has concentrated mainly on multipolar stimulation as a means of achieving current focussing and current steering, while modeling work on electrode design has been chiefly concerned with finding the optimal position and insertion depth of the electrode array. Finally, the present and future of computational modeling of the electrically stimulated cochlea is discussed.

A fast, stochastic, and adaptive model of auditory nerve responses to cochlear implant stimulation.

Cochlear implants (CIs) rehabilitate hearing impairment through direct electrical stimulation of the auditory nerve. New stimulation strategies can be evaluated using computational models. In this study, a computationally efficient model that accurately predicts auditory nerve responses to CI pulse train input was developed. A three-dimensional volume conduction and active nerve model developed at Leiden University Medical Center was extended with stochasticity, adaptation, and accommodation. This complete model includes spatial and temporal characteristics of both the cochlea and the auditory nerve. The model was validated by comparison with experimentally measured single fiber action potential responses to pulse trains published in the literature. The effects of pulse rate and pulse amplitude on spiking patterns were investigated. The modeled neural responses to CI stimulation were very similar to the single fiber action potential measurements in animal experiments. The models responses to pulse train stimulation with respect to spatial location were also investigated. Adaptation was stronger at the borders of the stimulated area than in the center. By combining spatial details with long-term temporal components and a broad implementation of stochasticity a comprehensive model was developed that was validated for long duration electric stimulation of a wide range of pulse rates and amplitudes. The model can be used to evaluate auditory nerve responses to cochlear implant sound coding strategies.

Variations in cochlear duct shape revealed on clinical CT images with an automatic tracing method

Cochlear size and morphology vary greatly and may influence the course of a cochlear implant electrode array during insertion and its final intra-cochlear position. Detailed insight into these variations is valuable for characterizing each cochlea and offers the opportunity to study possible correlations with surgical or speech perception outcomes. This study presents an automatic tracing method to assess individual cochlear duct shapes from clinical CT images. On pre-operative CT scans of 479 inner ears the cochlear walls were discriminated by interpolating voxel intensities along radial and perpendicular lines within multiplanar reconstructions at 1 degree intervals from the round window. In all 479 cochleas, the outer wall could be traced automatically up to 720 degrees. The inner wall and floor of the scala tympani in 192 cochleas. The shape of the cochlear walls were modelled using a logarithmic spiral function including an offset value. The vertical trajectories of the scala tympani exhibited a non-monotonous spiral slope with specific regions at risk for CI-related insertion trauma, and three slope categories could be distinguished. This presented automatic tracing method allows the detailed description of cochlear morphology and can be used for both individual and large cohort evaluation of cochlear implant patients.

Reducing interaction in simultaneous paired stimulation with CI

In this study simultaneous paired stimulation of electrodes in cochlear implants is investigated by psychophysical experiments in 8 post-lingually deaf subjects (and one extra subject who only participated in part of the experiments). Simultaneous and sequential monopolar stimulation modes are used as references and are compared to channel interaction compensation, partial tripolar stimulation and a novel sequential stimulation strategy named phased array compensation. Psychophysical experiments are performed to investigate both the loudness integration during paired stimulation at the main electrodes as well as the interaction with the electrode contact located halfway between the stimulating pair. The study shows that simultaneous monopolar stimulation has more loudness integration on the main electrodes and more interaction in between the electrodes than sequential stimulation. Channel interaction compensation works to reduce the loudness integration at the main electrodes, but does not reduce the interaction in between the electrodes caused by paired stimulation. Partial tripolar stimulation uses much more current to reach the needed loudness, but shows the same interaction in between the electrodes as sequential monopolar stimulation. In phased array compensation we have used the individual impedance matrix of each subject to calculate the current needed on each electrode to exactly match the stimulation voltage along the array to that of sequential stimulation. The results show that the interaction in between the electrodes is the same as monopolar stimulation. The strategy uses less current than partial tripolar stimulation, but more than monopolar stimulation. In conclusion, the paper shows that paired stimulation is possible if the interaction is compensated.

Pitch comparisons between cochlear‐implant stimulation and sounds played to a normal‐hearing contralateral ear.

A small group of cochlear implant users, having normal hearing in the unimplanted ear, compared the pitches of electrical and acoustic stimuli presented to the two ears. Comparisons were between 1031‐pps pulse trains and pure tones or between 12‐ or 25‐pps electric pulse trains and bandpass filtered acoustic pulse trains of the same rate. Three methods (pitch adjustment, constant stimuli, and interleaved adaptive procedures) were used. For all methods, we showed that the results can be strongly influenced by non‐sensory biases arising from the range of acoustic stimuli presented, and proposed a series of checks that should be made to alert the experimenter to those biases. We then showed that the results of comparisons that survived these checks do not deviate consistently from the predictions of a widely used cochlear frequency‐to‐place formula or of a computational cochlear model. In one case, the matches were reliable enough to successfully reveal the movement (slippage) of the electrode array. We also...