Ranjeet Kumar
Rajendra Memorial Research Institute of Medical Sciences
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Indian Journal of Pediatrics | 2004
Rajniti Prasad; Ranjeet Kumar; B. P. Jaiswal; Utpal Kant Singh
Miltefosine, a phosphocholine analogue originally developed as antimalignant drug, has been found to be highly active against leishmaniain vitro and animal model. 1,2 Based on these experiences this drug was tried against human visceral leishmaniasis and found to be highly effective and achieved 97% and 94% cure in phase 2 and phase 3 trial in children.
Indian Journal of Pediatrics | 1976
Utpal Kant Singh; Ranjeet Kumar
Congenital hypertrophic pyloric stenosis, an important cause of intractable vomiting in infants is diagnosed clinically and confirmed ultrasonographically. Other useful interventions are plain radiography and berium study. Differential diagnosis includes pylorospasm and gastroesophageal reflux. Management protocol includes correction of dehydration and electrolyte imbalance and either Fredet Ramstedt pyloromyotomy or medical treatment with atropine sulphate. Atropine is initially given intravenously till vomiting is controlled and then orally at double the effective I.V. done for another 3 weeks. Atropine sulphate is generally well tolerated and side effects are few like tachycardia, raised SGPT and hyperthermia. Atropine sulphate is very effective, cheap, safe and perhaps more acceptable treatment option for CHPS.
PLOS ONE | 2016
Sushmita Das; Ganesh Chandra Sahoo; Pradeep Das; Utpal Kant Singh; Anil K. Jaiswal; Prachi P. Singh; Ranjeet Kumar; R. Kumar
Objectives To evaluate the contribution of breastfeeding to Rotavirus (RV)-induced antigenemia and/or RNAemia and disease severity in Indian children (<2 yrs age). Methods Paired stool and serum samples were collected from (a) hospitalized infants with diarrhea (n = 145) and (b) healthy control infants without diarrhea (n = 28). Stool RV-antigen was screened in both groups by commercial rapid-test and enzyme immunoassay. The disease severity was scored and real-time-PCR was used for viral-load estimation. Serum was evaluated for RV-antigenemia by EIA and RV-RNAemia by RT-PCR. Data was stratified by age-group and breastfeeding status and compared. Results Presence of RV-antigenemia and RV-RNAemia was positively related with presence of RV in stool. Disease severity and stool viral-load was significantly associated with RV-antigenemia[(r = 0.74; CI:0.66 to 0.84; P<0.0001,R2 = 0.59) and (r = -0.55; CI:-0.68 to -0.39; P<0.0001,R2 = 0.31) respectively], but not with RV-RNAemia. There was significant reduction in RV-antigenemiarate in the breast-fed group compared to non-breastfed infants, especially in 0–6 month age group (P<0.001). Non-breastfed infants were at risk for RV-antigenemia with severe disease manifestations in form of high Vesikari scores correlating with high fever, more vomiting episodes and dehydration. Conclusion RV-antigenemia was common in nonbreastfed children with severe RV-diarrhea and correlated with stool RV-load and disease severity.
Indian Journal of Pediatrics | 2002
Utpal Kant Singh; Rajniti Prasad; Ranjeet Kumar; B. P. Jaiswal
Diarrhoea, a major cause of morbidity and mortality can be produced by a variety of etiological factors. Management protocol includes assessment of the child, physical examination, lab-evaluation, assessment of severity of dehydration and rehydration therapy using either of the following-WHO-ORS, Home available fluids (HAF), sugar salt solution (SSS), improve WHO-ORS, Amino acid fortified ORS, rice based ORS, low osmolarity ORS. Intravenous fluids are required if patients can’t accept orally. Commonly observed electrolyte disturbances are hypernatremia, hyponatremia and hypokalemia. Conculsion is a common problem and can result due to electrolyte imbalance, cavernous sinus thrombosis, associated meningitis, shigella eccephalopathy and hypoglycemia in undernourished children. Treatment includes I.V. diazepam and I.V. glucose and correction of electrolyte imbalance. Additional treatment interventions include antimicrobial drugs including antibiotics, antimotility drugs, absorbents, nutritional and micro and macro nutrient supplementation.
Indian Pediatrics | 2005
Utpal Kant Singh; Ranjeet Kumar; Rajniti Prasad
Indian Pediatrics | 2001
Utpal Kant Singh; Ranjeet Kumar; Shivani Suman
Indian Journal of Pediatrics | 2002
Utpal Kant Singh; Ranjeet Kumar
Indian Pediatrics | 2006
Utpal Kant Singh; Rajniti Prasad; Ranjeet Kumar; Bir Prasad Jaiswal
Journal of the Indian Medical Association | 2004
Rajniti Prasad; Ranjeet Kumar; B. P. Jaiswal; Utpal Kant Singh
Archive | 2003
Kant Singh Utpal; Rajiniti Prasad; Ranjeet Kumar; Shivani Suman
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Rajendra Memorial Research Institute of Medical Sciences
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