Raymond F. Krzesicki

BIOCHEMICAL APPROACHES TO MONITORING HUMAN POPULATIONS FOR GERMINAL MUTATION RATES: I. ELECTROPHORESIS*

The advent of relatively inexpensive and convenient techniques for identifying genetic variants of proteins on the basis of differences in molecular charge, thermostability, or, for enzymes, activity has opened a new chapter in the study of mutation. In this presentation, we shall speak to the progress being made in our understanding of human mutation rates and in monitoring programs because of the ability to readily detect charge and size variations in proteins; in a companion presentation, Dr. Mohrenweiser will address the progress being made with reference to the search for mutations affecting thermo stability or activity levels.