Raymond J. Thibault

Functionalization of polymer microspheres using click chemistry.

We describe a new method to covalently link a wide variety of molecules to the surface of colloidal polymer microspheres using the Cu(I)-catalyzed azide-alkyne reaction, most commonly known under the class of reactions identified by the term click chemistry. The method is generic and readily applied to a spectrum of colloidal particle systems allowing surfaces to be tailored with virtually any desired functionality. To demonstrate this method, polystyrene microspheres were functionalized with two different polyethylene oxide-based polymers, and changes in hydrodynamic radii after functionalization were measured using dynamic light scattering. Control of surface functional groups was demonstrated by fluorescently labeling the colloidal microspheres using the same Cu-catalyzed azide-alkyne cycloaddition reaction.

Feature Article: Recognition-Mediated Assembly of Polymers

The concepts of molecular recognition present powerful tools for the control of polymer assemblies. In recent years, numerous researchers have coupled supramolecular chemistry with polymer synthesis and engineering, creating a discipline located squarely at the interface of chemistry and polymer science. This review will present an overview of the field of supramolecular polymer science, establishing fundamental differences between main- and sidechain supramolecular polymers and demonstrating the utility of these methodologies in polymer structure control, guest sensing, surface deposition, and in the formation of microscale aggregates.