Raymond L. Sherman

Lipoid nephrosis in Hodgkin's disease

Abstract Two cases of Hodgkins disease presenting as the nephrotic syndrome are described. Evaluation of the renal biopsy specimens by light microscopy, electron microscopy and immuno-fluorescent antibody staining was most compatible with a lipoid nephrosis type of lesion. In both cases there was a prompt and prolonged remission of the nephrotic syndrome when the Hodgkins disease was treated with radiation therapy.

Hereditary nephritis with a characteristic renal lesion.

Abstract Light and electron microscopic studies were performed on renal tissue from four involved members of a family with hereditary nephritis. The two females studied had no apparent deafness or renal insufficiency, but a nonspecific mild increase in mesangial matrix was noted on light microscopic examination of the renal biopsy specimen. The two males had neurosensory deafness. One had advanced renal insufficiency with glomerular sclerosis, whereas the other had no azotemia and less histopathologic change. However, all four had a characteristic ultrastructural lesion consisting of glomerular basement membrane splitting separated by clear spaces with the accumulation of small dense particles between the thin layers. This change may be specific for certain forms of hereditary nephritis.

Nephrotic Syndrome in Hodgkin's Disease.

Excerpt Idiopathic lipoid nephrosis usually does not complicate other diseases. Recently two patients presenting with the nephrotic syndrome without evidence of amyloidosis or renal vein thrombosis...

Allergic Interstitial Nephritis with Diuretics

Excerpt To the editor: After the report by Lyons and associates (1) of four cases of allergic interstitial nephritis associated with diuretic agents, a similar clinical situation was seen by us in ...

Proximal Tubular Dysfunction in the Nephrotic Syndrome.

Excerpt Abnormalities of proximal tubular function such as glycosuria, aminoaciduria, and defects in acidification have been described previously in the nephrotic syndrome. In this study proximal t...

N-acetyl-ß-glucosaminidase and ß2-Microglobulin in Renal Disease-Reply

In Reply. —We thank Dr Sogaard for his comments. His generalization that NAG excretion is correlated with GFR should not always be applied when one is comparing different types of disease. For example, our patients with obstructive nephropathy had higher serum creatinine values than our patients with membranous nephropathy (5.7±2.2 [mean±SD] v 2.1±1.9; P v 410±349; P