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Rebecca A. Stephenson

Hoffmann-La Roche

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Publication

Featured researches published by Rebecca A. Stephenson.

Bioorganic & Medicinal Chemistry Letters | 2009

Non-nucleoside inhibitors of HCV polymerase NS5B. Part 2: Synthesis and structure―activity relationships of benzothiazine-substituted quinolinediones

Javier de Vicente; Robert Than Hendricks; David Bernard Smith; Jay Bradford Fell; John Fischer; Stacey Renee Spencer; Peter J. Stengel; Peter Mohr; John E. Robinson; James F. Blake; Ramona K. Hilgenkamp; Calvin Yee; George Adjabeng; Todd R. Elworthy; Jahari Laurant Tracy; Elbert Chin; Jim Li; Beihan Wang; Joe Timothy Bamberg; Rebecca A. Stephenson; Connie Oshiro; Seth F. Harris; Manjiri Ghate; Vincent Leveque; Isabel Najera; Sophie Le Pogam; Sonal Rajyaguru; Gloria Ao-Ieong; Ludmila Alexandrova; Susan Larrabee

A new series of benzothiazine-substituted quinolinediones were evaluated as inhibitors of HCV polymerase NS5B. SAR studies on this series revealed a methyl sulfonamide group as a high affinity feature. Analogues with this group showed submicromolar potencies in the HCV cell based replicon assay. Pharmacokinetic and toxicology studies were also performed on a selected compound (34) to evaluate in vivo properties of this new class of inhibitors of HCV NS5B polymerase.

Journal of Medicinal Chemistry | 1985

Diterpenoid sweeteners. Synthesis and sensory evaluation of stevioside analogues with improved organoleptic properties

Grant E. Dubois; Rebecca A. Stephenson

Journal of Medicinal Chemistry | 1981

Dihydrochalcone sweeteners. A study of the atypical temporal phenomena.

Grant E. Dubois; Guy A. Crosby; Rebecca A. Stephenson

Journal of Medicinal Chemistry | 1996

Structure-activity relationships for inhibition of inosine monophosphate dehydrogenase by nuclear variants of mycophenolic acid.

Peter H. Nelson; Stephen F. Carr; Bruce H. Devens; Elsie M. Eugui; Fidencio Franco; Carlos Gonzalez; Ronald Charles Hawley; David G. Loughhead; David J. Milan; Eva Papp; John W. Patterson; Sussan Rouhafza; Eric Brian Sjogren; David Bernard Smith; Rebecca A. Stephenson; Francisco Xavier Talamas; Ann-Marie Waltos; Robert James Weikert; John C. Wu

Journal of Agricultural and Food Chemistry | 1984

Diterpenoid sweeteners. Synthesis and sensory evaluation of biologically stable analogues of stevioside

Grant E. Dubois; Leonard A. Bunes; Paul S. Dietrich; Rebecca A. Stephenson

Journal of Medicinal Chemistry | 1981

Diterpenoid sweeteners. Synthesis and sensory evaluation of stevioside analogues nondegradable to steviol.

Grant E. Dubois; Paul S. Dietrich; Janice F. Lee; Geoff V. McGarraugh; Rebecca A. Stephenson

Archive | 1981

Glucosubstituented diterpenoid sweeteners

Rebecca A. Stephenson; Paul S. Dietrich; Grant E. Dubois; Leonard A. Bunes

Journal of Organic Chemistry | 1982

Observations on the chemistry of .alpha.-azido ester. Efficient synthesis of a potently sweet homoserine-dihydrochalcone conjugate

Grant E. Dubois; Guy A. Crosby; Geoff V. McGarraugh; Steve Y. W. Ng; Rebecca A. Stephenson; Patricia C. Wang; Robert E. Wingard

Archive | 1979

Alpha amino acid dihydrochalcones

Grant E. Dubois; Rebecca A. Stephenson; Guy A. Crosby

Archive | 1980

Sulfamo dihydrochalcone sweeteners

Grant E. Dubois; Rebecca A. Stephenson

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Grant E. Dubois

The Coca-Cola Company

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David Bernard Smith

Hoffmann-La Roche

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Beihan Wang

Hoffmann-La Roche

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Calvin Yee

Hoffmann-La Roche

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Connie Oshiro

Hoffmann-La Roche

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David G. Loughhead

Hoffmann-La Roche

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David J. Milan

Harvard University

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Elbert Chin

Hoffmann-La Roche

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Eric Brian Sjogren

Hoffmann-La Roche

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Fidencio Franco

Hoffmann-La Roche

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