Regina S. Druz

The feminine mystique of AUC

In her well-known book, ‘‘The Feminine Mystique’’ (1963), psychologist Betty Friedan argues that biased portrayal of women in the media created a perception that women were naturally fulfilled by domestic duties and risked unhappiness in choosing career path over family. Coining the term ‘‘feminine mystique’’ to describe this phenomenon, the author convincingly showed how it precluded many women from self-actualization beyond their biological role, and stunted their growth. Mrs. Friedan book is widely credited with ushering a second wave of feminism in the 1970s, and advancing opportunities for women in all spheres of American life. Betty Friedan died of congestive heart failure in 2006, at the age of 85. In 2003, forty years after the ‘‘Feminine Mystique,’’ the National Heart, Lung and Blood Institute, the American Heart Association, and other organizations joined forces to raise awareness with a goal to educate and unravel gender disparities in pathophysiology, presentation, and prognosis of heart disease. It is ironic, however, that we still have our own case of ‘‘feminine mystique’’ in myocardial perfusion imaging (MPI). Several recent studies suggested that women are more likely to receive inappropriate (rarely appropriate) testing, and some questioned if the use of the appropriateness use criteria (AUC, 2009) for SPECT MPI in women is justified given lower age-adjusted prevalence of CAD, and differences in pathophysiology and clinical presentations. The use of AUC is impactful on referral and reimbursement, as well as downstream resource utilization. In this issue of the journal, Doukky et al. investigated the appropriateness of AUC SPECT for women, dispelling the ‘‘feminine mystique’’ of MPI observed in prior studies. Doukky et al. report on a sub-study of the prospectively recruited cohort of 1511 patients, all undergoing clinically indicated SPECT in the officebased setting, with the majority referred by primary care physicians. The primary end-point was a composite of major adverse cardiac events (MACE), defined as cardiac death, non-fatal myocardial infarction, or coronary revascularizations triggered by MPI findings, while the secondary end-point was a similarly defined composite MACE for early (B6 months) or late ([6 months) postMPI events. Revascularization procedures performed within 6 months of SPECT were considered to be triggered by the MPI findings while those beyond the 6 months were deemed to be due to a clinical change. Using regression models, authors investigated gender association of observed outcomes with the clinical and imaging predictors across the AUC spectrum, with AUC category assigned by a computer-based logic. As may be expected, women undergoing SPECT MPI were older but at a lower 10-year Framingham risk, with lower likelihood and lower prevalence of obstructive CAD, and less likely to exercise. Women were more likely to be tested for chest pain syndromes, and had greater association for inappropriate SPECT MPI (OR 27.86, P\ .001) even after adjustment for the clinical covariates of AUC determination (age, risk factors, ischemic equivalent symptoms, interpretable ECG, ability to exercise). Women had significantly lower prevalence of abnormal MPI, including ischemia and left ventricular dysfunction, in the entire cohort, and across all AUC subgroups (Figure 1). After adjusting for the clinical covariates, no interaction was observed between gender and the AUC categories as determinants of abnormal MPI findings, indicating that women had similar relative risk of abnormal MPI irrespective of the AUC group (Figure 2). Predictably, less abnormalities Reprint requests: Regina S. Druz, MD, FACC, FASNC, Integrative Cardiology Center of Long Island, 121 Jericho Turnpike, Mineola, NY; rdruzmd@aol.com, md@iccli.com J Nucl Cardiol 2016;23:706–9. 1071-3581/

Post-ischemic left ventricular dysfunction is detected on adenosine gated SPECT in patients with extensive coronary artery disease

34.00 Copyright 2015 American Society of Nuclear Cardiology.

Myocardial perfusion and function: Single photon emission computed tomography

Abstract Background: Ischemic left ventricular (LV) dysfunction may occur after exercise, but is regarded as uncommon after vasodilator stress. We evaluated the prevalence of LV dysfunction post-adenosine (ado) in relation to the extent of reversible perfusion defects (PD) and angiographic coronary artery disease (CAD). Methods: 86 patients (pts.) referred for adenosine dual-isotope gated SPECT were studied: 43 with ≥ 1 reversible PD, and 43 age and sex matched controls without CAD who had normal LV perfusion and function. Extent of reversible PD was defined by 20-segment/5-point summed difference score (SDS), and SDS≥ 8 defined severe PD. LV ejection fraction (EF) and segmental wall thickening (WT) were quantified at rest and 60 minutes post-adenosine by QGS (Cedars-Sinai Medical Center, Los Angeles, CA). Coronary angiography was performed in 36/43 pts. with PD. Results: See Table Extent PD EF ado Drop in WT ado vs. rest Stenosis Vessels with stenosis ≥ 50% LAD stenosis ≥ 50% (% pts) SDS 55 ± 12% −3 ± 13% 38 ± 33% 1.1 ± 1.1 38% SDS ≥ 8 (n = 25) 44 ± 15% −13 ± 16% 69 ± 28% 2.5 ± 1.1 82% p 0.04 0.02 LAD = left anterior descending. SD = standard deviation. Conclusion: Global and segmental LV dysfunction indicative of stunning was observed in pts. with severe reversible PD post-adenosine, and identified pts. with more extensive CAD.