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Featured researches published by Reimei Moroi.


Journal of The Chemical Society-perkin Transactions 1 | 1988

Syntheses and alkaline hydrolyses of 2,2′-imino- and 2,2′-(substituted imino)-1-(2′-deoxy-β-D-arabinofuranosyl)uracils

Katsumaro Minamoto; Kishiko Azuma; Toshihiro Tanaka; Hiroshi Iwasaki; Shoji Eguchi; Reimei Moroi

In order to examine the possiblity of ‘up’ amination of the sugar part of pyrimidine nucleosides through pyrimidine N-cyclonucleosides, 2,2′-imino-1-(2′-deoxy-β-D-arabinofuranosyl)uracil (6g) and various N-substituted derivatives of (6g),(6a–f) were synthesized by amination-cyclization reactions of 2′-O-tosyl-2,5′-anhydrouridine (5). The latter was synthesized from 2,5′-anhydrouridine (4) by 2′,3′-O-dibutylstannylation followed by in situ tosylation. N-p-Methoxyphenylisocytidine (7) obtainable from (4) was also cyclized to (6d) by treatment with 1,1′-carbonyldi-imidazole. 2,2′-Arylimino analogues (6c,d) were hydrolysed with 2M NaOH–MeOH (1:1) extremely rapidly to give 2′-deoxy-2′-arylamino uracil-arabinosides (8a,b). The 2′,3′-dideoxy-2′,3′-(N-phenyl)imino analogue of arabinoside (8a), (9), was used for the purpose of structural corroboration of (8a,b). Similar dehydrative cyclization of (6g) gave the 5′,N-anhydro derivative, compound (10), while alkali-treatment gave a fragmentation product, imidazo[1,2-a]pyrimidin-7(8H)-one (11). Spectroscopic arguments which support structures (6), (10), and (11) are also presented.


Journal of The Chemical Society, Chemical Communications | 1983

Dimerization of 2-alkyl-6-methyl-4H-1,3-thiazin-4-ones

Yutaka Yamamoto; Shuhei Ohnishi; Reimei Moroi; Atomi Yoshida

Two unusual modes of dimerization of 2-alkyl-6-methyl-4H-1,3-thiazin-4-ones were observed; one gave the linearly combined dimers (3) and the other led to the novel spiro-compound (4); the structure of one of the spiro-compounds (4a) was confirmed by X-ray crystallography.


Chemical & Pharmaceutical Bulletin | 1995

Effect of Dehydration on the Formation of Levofloxacin Pseudopolymorphs

Hiroaki Kitaoka; Chisa Wada; Reimei Moroi; Hideo Hakusui


Journal of Medicinal Chemistry | 1972

Medicinal chemical studies on antiplasmin drugs. 4. Chemical modification of trans-4-aminomethylcyclohexanecarboxylic acid and its effect on antiplasmin activity

Atsuji Okano; Masato Inaoko; Shoichi Funabashi; Masahiro Iwamoto; Sumiro Isoda; Reimei Moroi; Yasushi Abiko; Miyoshi Hirata


Analytical Sciences | 1991

Crystal Structure of Ofloxacin Perchlorate

Atomi Yoshida; Reimei Moroi


Chemical & Pharmaceutical Bulletin | 1977

Metabolism of Budralazine, a New Antihypertensive Agent. II. Metabolic Pathways of Budralazine in Rats

Reimei Moroi; Kenji Ono; Tadashi Saito; Takeshi Akimoto; Mitsuji Sano


Chemical & Pharmaceutical Bulletin | 1976

Structures of Reaction Products from 1-Hydrazino-phthalazine and Some Carbonyls

Katsujiro Ueno; Reimei Moroi; Masayuki Kitagawa; Kohachiro Asano; Seiichi Miyazaki


Chemical & Pharmaceutical Bulletin | 1992

Synthesis and antiallergy activity of [1,3,4]thiadiazolo[3,2-a]-1,2,3-triazolo[4,5-d]pyrimidin-9(3H)-one derivatives II: 6-alkyl- and 6-cycloalkylalkyl derivatives

Shuichi Yokohama; Tamotsu Miwa; Shunzo Aibara; Hiroyuki Fujiwara; Hiroo Matsumoto; Kiyoshi Nakayama; Teiji Iwamoto; Mikiko Mori; Reimei Moroi; Wataru Tsukada; Sumiro Isoda


Chemical & Pharmaceutical Bulletin | 1983

1,3-Oxazines and related compounds. VII. Unusual dimerization of 2-alkyl-4H-1,3-thiazin-4-one derivatives and the structures of the dimers.

Yutaka Yamamoto; Shuhei Ohnishi; Reimei Moroi; Atomi Yoshida


Chemical & Pharmaceutical Bulletin | 1968

Medicinal Chemical Studies on Antiplasmin Drugs. II. Separation of Stereoisomers of 4-Aminomethylcyclohexanecarboxylic Acid and Assignment of Their Configuration

Takeo Naito; Atsuji Okano; Tosaku Miki; Masato Inaoka; Reimei Moroi; Masao Shimizu

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Shuhei Ohnishi

Mochida Pharmaceutical Co.

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