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Dive into the research topics where Reina Natero is active.

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Featured researches published by Reina Natero.


Bioorganic & Medicinal Chemistry Letters | 2000

1-Phenyl-5-pyrazolyl ureas: potent and selective p38 kinase inhibitors

Jacques Dumas; Holia Hatoum-Mokdad; Robert Sibley; Bernd Riedl; William J. Scott; Mary Katherine Monahan; Timothy B. Lowinger; Catherine Brennan; Reina Natero; Tiffany Turner; Jeffrey S Johnson; Robert W. Schoenleber; Ajay Bhargava; Scott Wilhelm; Timothy J Housley; Gerald Ranges; Alka Shrikhande

Inhibitors of the MAP kinase p38 are potentially useful for the treatment of arthritis and osteoporosis. Several 2,3-dichlorophenyl ureas were identified as small-molecule inhibitors of p38 by a combinatorial chemistry effort. Optimization for cellular potency led to the discovery of a new class of potent and selective p38 kinase inhibitors, exemplified by the 1-phenyl-5-pyrazolyl urea 7 (IC50 = 13 nM).


Synthetic Communications | 2004

Microwave‐Assisted One‐Step Synthesis of Substituted 2‐Chloromethyl‐1,3,4‐oxadiazoles

Reina Natero; Dmitry Koltun; Jeffery A. Zablocki

Abstract We have developed a simple one‐step synthesis of 2‐chloromethyl‐1,3,4‐oxadiazoles from commercially available acylhydrazides using 1‐chloro‐2,2,2‐trimethoxyethane as a solvent under microwave irradiation.


Archive | 2001

Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors

Bernd Riedl; Jacques Dumas; Uday Khire; Timothy B. Lowinger; William J. Scott; Roger A. Smith; Jill E. Wood; Mary-Katherine Monahan; Reina Natero; Joel Renick; Robert Sibley


Archive | 2000

.omega.-carboxy aryl substituted diphenyl ureas as p38 kinase inhibitors

Bernd Riedl; Jacques Dumas; Uday Khire; Timothy B. Lowinger; William J. Scott; Roger A. Smith; Jill E. Wood; Mary-Katherine Monahan; Reina Natero; Joel Renick; Robert Sibley


Organic Process Research & Development | 2002

A Scaleable Synthesis of BAY 43-9006: A Potent Raf Kinase Inhibitor for the Treatment of Cancer

Donald Bankston; Jacques Dumas; Reina Natero; Bernd Riedl; Mary-Katherine Monahan; Robert Sibley


Bioorganic & Medicinal Chemistry Letters | 2004

Omega-carboxypyridyl substituted ureas as Raf kinase inhibitors: SAR of the amide substituent.

Uday Khire; Donald Bankston; James Barbosa; David R. Brittelli; Yolanda V Caringal; Robert O. Carlson; Jacques Dumas; Todd Gane; Sarah Heald; Barbara Hibner; Jeffrey S Johnson; Michael E. Katz; Nancy Kennure; Jill Kingery-Wood; Wendy Lee; Xiao-Gao Liu; Timothy B. Lowinger; Ian McAlexander; Mary-Katherine Monahan; Reina Natero; Joel Renick; Bernd Riedl; Hong Rong; Robert Sibley; Roger A. Smith; Donald John Wolanin


Archive | 2001

Omega-carboxyaryl subsituted diphenyl ureas as raf kinase inhibitors

Bernd Riedl; Jacques Dumas; Uday Khire; Timothy B. Lowinger; William J. Scott; Roger A. Smith; Jill E. Wood; Mary-Katherine Monahan; Reina Natero; Joel Renick; Robert Sibley


Bioorganic & Medicinal Chemistry Letters | 2004

CVT-4325: a potent fatty acid oxidation inhibitor with favorable oral bioavailability:

Elfatih Elzein; Prabha Ibrahim; Dmitry Koltun; Ken Rehder; Kevin Shenk; Timothy A. Marquart; Bob Jiang; Xiaofen Li; Reina Natero; Yuan Li; Marie Nguyen; Suresh Kerwar; Nancy Chu; Daniel Soohoo; Jia Hao; Victoria Y. Maydanik; David Lustig; Dewan Zeng; Kwan Leung; Jeff Zablocki


Archive | 2001

ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors

Bernd Riedl; Jacques Dumas; Uday Khire; Timothy B. Lowinger; William J. Scott; Roger A. Smith; Jill E. Wood; Reina Natero


Archive | 2003

Compounds dor increasing abca-1 expression useful for treating coronary artery disease and atherosclerosis

Prabha Ibrahim; Michael Campbell; Robert Jiang; Christopher Morrison; Kevin Shenk; William Shirley; Jeff Zablocki; Dmitry Koltun; Reina Natero

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