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Dive into the research topics where Reinhard Fleer is active.

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Featured researches published by Reinhard Fleer.


Current Opinion in Biotechnology | 1992

Engineering yeast for high level expression

Reinhard Fleer

As a eukaryotic microbe, yeast remains an attractive host for the expression of a large variety of foreign proteins, including viral antigens, enzymes used as food additives and therapeutic agents. Important progress has been made in the understanding of the critical parameters influencing product yield, and a number of novel tools for the genetic engineering of powerful yeast expression systems have been developed. This review focuses on recent findings in foreign gene expression in the yeasts Saccharomyces, Pichia, Hansenula, and Kluyveromyces.


Archive | 1990

Albumin derivatives with therapeutic functions

Jérôme Becquart; Reinhard Fleer; Philippe Hervé Hirel; David Klatzmann; Didier Landais; Jean-François Mayaux; Patrice Yeh


Proceedings of the National Academy of Sciences of the United States of America | 1992

Design of yeast-secreted albumin derivatives for human therapy: biological and antiviral properties of a serum albumin-CD4 genetic conjugate.

Patrice Yeh; Didier Landais; M Lemaître; Isabelle Maury; J Y Crenne; J Becquart; A Murry-Brelier; F Boucher; G Montay; Reinhard Fleer


Gene | 1991

High-level secretion of correctly processed recombinant human interleukin-1β in Kluyveromyces lactis

Reinhard Fleer; Xin Jie Chen; Nacima Amellal; Patrice Yeh; Alain Fournier; Françoise Guinet; Nathalie Gault; Didier Faucher; Françoise Folliard; Fukuhara Hiroshi; Jean-François Mayaux


Archive | 1993

Antithrombotic polypeptides as antagonists of the binding of vwf to platelets or to subendothelium

Reinhard Fleer; Alain Fournier; Jean-Dominique Guitton; Gerard Jung; Patrice Yeh


Archive | 2002

Fusion polypeptides of human serum albumin and a therapeutically active polypeptide

Reinhard Fleer; Alain Fournier; Jean-Dominique Guitton; Gerard Jung; Patrice Yeh


Gene | 1995

Isolation and characterization of the gene encoding xylose reductase from Kluyveromyces lactis

Patrick Billard; Sandrine Ménart; Reinhard Fleer; Monique Bolotin-Fukuhara


Gene | 1992

Sequence of the Kluyveromyces lactis β-galactosidase : comparison with prokaryotic enzymes and secondary structure analysis

Olivier Poch; Hervé L'Hôte; Vincent Dallery; Françoise Debeaux; Reinhard Fleer; Regis Sodoyer


Applied and Environmental Microbiology | 1999

Use of the KlADH4 Promoter for Ethanol-Dependent Production of Recombinant Human Serum Albumin in Kluyveromyces lactis

Michele Saliola; Cristina Mazzoni; Nicola Solimando; Alessandra Crisà; Claudio Falcone; Gerard Jung; Reinhard Fleer


Archive | 1993

Modified fungal cells and method for producing recombinant products

Widmar Prof Dr Tanner; Sabine Strahl-Bolsinger; Reinhard Fleer; Alain Fournier

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