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Featured researches published by Renata Fagnani.


Medical Mycology | 2013

Is the incidence of candidemia caused by Candida glabrata increasing in Brazil? Five-year surveillance of Candida bloodstream infection in a university reference hospital in southeast Brazil

Maria Luiza Moretti; Plínio Trabasso; Luzia Lyra; Renata Fagnani; Mariangela Ribeiro Resende; Luís Gustavo de Oliveira Cardoso; Angélica Zaninelli Schreiber

From 2006 to 2010, a retrospective study was conducted in a university referral tertiary care hospital to study the frequency and distribution of Candida species in different medical specialties. The use of mechanical ventilation, central venous catheter, and urinary catheter were recorded per 1,000 patient-days and the use of antifungals was calculated using defined daily dose (DDD). A total of 313 episodes were identified and the overall incidence was 0.54 (0.41-0.71) episodes per 1,000 patient-days. Candida albicans caused 44% of the overall episodes, followed by C. tropicalis (21.7%), C. parapsilosis (14.4%), C. glabrata (11.2%), and C. krusei (3.5%). The incidence of C. glabrata significantly increased from 2006-2010 (range: 4.8-23.5%) (P = 0.024). Candida glabrata was associated with malignancies (P = 0.004) and C. krusei with hematologic malignancies (P < 0.0001). The use of antifungals was higher in the hematology/bone marrow transplant units and represented 40% of all fluconazole prescription in the hospital. There was no correlation with the use of fluconazole and the increasing ratio of C. glabrata (r = 0.60). The use of invasive devices was significantly higher in the intensive care units (ICUs) than the medical and surgical emergencies units (P < 0.001). In contrast, the emergencies had higher incidence of candidemia (2-2.1 episodes/1,000 patient-days) than the ICUs (1.6 episodes 1,000 patient-days). Candida glabrata candidemia showed a significant increase in contrast to the current national literature where C. parapsilosis remained the most important non-C. albicans Candida species in Brazilian hospitals. Our findings suggested that the increasing incidence of C. glabrata was not associated with use of fluconazole and other risk factors might play an important role.


Revista Da Sociedade Brasileira De Medicina Tropical | 2012

Successful prevention of the transmission of vancomycin-resistant enterococci in a Brazilian public teaching hospital

Flávia Alves Ferreira Rossini; Renata Fagnani; Mirtes Loeschner Leichsenring; Sônia Regina Pérez Evangelista Dantas; Luís Gustavo de Oliveira Cardoso; Carlos Emílio Levy; Maria Luiza Moretti; Plínio Trabasso

INTRODUCTION Vancomycin-resistant enterococci (VRE) can colonize or cause infections in high-risk patients and contaminate the environment. Our objective was to describe the epidemiological investigation of an outbreak of VRE, the interventions made, and their impact on its control. METHODS We conducted a retrospective, descriptive, non-comparative study by reviewing the charts of patients with a VRE-positive culture in the University Hospital of Campinas State University, comprising 380 beds, 40 of which were in intensive care units (ICUs), who were admitted from February 2008-January 2009. Interventions were divided into educational activity, reviewing the workflow processes, engineering measures, and administrative procedures. RESULTS There were 150 patients, 139 (92.7%) colonized and 11 (7.3%) infected. Seventy-three percent were cared for in non-ICUs (p = 0.028). Infection was more frequent in patients with a central-line (p = 0.043), mechanical ventilation (p = 0.013), urinary catheter (p = 0.049), or surgical drain (p = 0.049). Vancomycin, metronidazole, ciprofloxacin, and third-generation cephalosporin were previously used by 47 (31.3%), 31 (20.7%), 24 (16%), and 24 (16%) patients, respectively. Death was more frequent in infected (73%) than in colonized (17%) patients (p < 0.001). After the interventions, the attack rate fell from 1.49 to 0.33 (p < 0.001). CONCLUSIONS Classical risk factors for VRE colonization or infection, e.g., being cared for in an ICU and previous use of vancomycin, were not found in this study. The conjunction of an educational program, strict adhesion to contact precautions, and reinforcement of environmental cleaning were able to prevent the dissemination of VRE.


Open Forum Infectious Diseases | 2014

948Impact of active surveillance program to control VRE in a university hospital with low endemic rates

Luís Gustavo de Oliveira Cardoso; Renata Fagnani; Mirtes Loeschner Leichsenring; Sônia Regina Pérez Evangelista Dantas; Luis Felipe Bachur; Christian Hoffling; Plínio Trabasso; Maria Luiza Moretti

BACKGROUND Several strategies have been implemented to control VRE in hospital outbreaks. The delay in time for detecting the initial VRE colonization/infection may lead to a huge hospital dissemination. A major goal in healthcare facilities has been to stop VRE transmission. VRE was first isolated in our hospital in June 2007, from a urine culture of a patient from the gastroenterology clinic with an advanced stage of cirrhosis. From 2007 to 2009, a VRE outbreak in our hospital was controlled with: active surveillance of rectal swabs, isolation of colonized/infected patients, barrier precautions and antibiotic policies . Since 2009, protocols of control measures have been continuously implemented. This study evaluated the impact of maintaining the protocols for controlling VRE colonization/infection during the period of 2010 to July 2014 compared to the study done in 2007 to 2009


European Journal of Clinical Microbiology & Infectious Diseases | 2011

Controlling a vancomycin-resistant enterococci outbreak in a Brazilian teaching hospital

Maria Luiza Moretti; L. G. de Oliveira Cardoso; Carlos Emílio Levy; A. Von Nowakosky; Luis Felipe Bachur; O.J. Bratfich; Mirtes Loeschner Leichsenring; Renata Fagnani; S. M. Peres Evangelista Dantas; Mariângela Ribeiro Resende; Plínio Trabasso


Mycopathologia | 2015

Isolation and Drug Susceptibility of Candida parapsilosis Sensu Lato and other Species of C. parapsilosis Complex from Patients with Blood Stream Infections and Proposal of a Novel LAMP Identification Method for the Species

Plínio Trabasso; Tetsuhiro Matsuzawa; Renata Fagnani; Yasunori Muraosa; Kenichiro Tominaga; Mariangela Ribeiro Resende; Katsuhiko Kamei; Yuzuru Mikami; Angélica Zaninelli Schreiber; Maria Luiza Moretti


BIS. Boletim do Instituto de Saúde (Impresso) | 2013

Portal de manuais do Hospital de Clínicas da Unicamp: amplo acesso às informações institucionais

Eliane Molina Psaltikidis; Marcelo A. Oliveira; Edson Luiz Kitaka; Mirtes Loeschner Leichsenring; Renata Fagnani; Jacques Gama; Cláudia C. M. Santos; Joicilene Oliveira Luciano; Manoel Barros Bertolo


Infectious diseases | 2015

Mortality related to candidemia and risk factors associated with non-Candida albicans

Renata Fagnani; Mariângela Ribeiro Resende; Plínio Trabasso; Yuzuru Mikami; Angélica Zaninelli Schreiber; Ariane Fidelis Busso Lopes; Yasunori Muraosa; Katsuhiko Kamei; Maria Luiza Moretti


Value in Health | 2017

Identifying Inpatients To Outpatient Parenteral Antimicrobial Therapy: A Point Prevalence Study

Eliane Molina Psaltikidis; Resende; Kp Mattos; Mirtes Loeschner Leichsenring; Renata Fagnani; Tc Lima; Luís Gustavo de Oliveira Cardoso; Luis Felipe Bachur; Christian Cruz Hofling; Maria Luiza Moretti


Value in Health | 2017

Effectiveness of The Peripherally Inserted Central Venous Catheter in Adult and Pediatric Patients

Sr Dantas; Renata Fagnani; Tc Lima; Va Silva; Mo Azevedo; Gc Bueno; Ap Gadanhoto; Ap Oliveira; Eliane Molina Psaltikidis; D Carrara; Resende


Archive | 2015

Estudo epidemiológico das candidemias hospitalares de pacientes adultos atendidos no Hospital das Clínicas da Unicamp

Renata Fagnani; Mariângela Ribeiro Resende

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Maria Luiza Moretti

State University of Campinas

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Plínio Trabasso

State University of Campinas

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Carlos Emílio Levy

State University of Campinas

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Luis Felipe Bachur

State University of Campinas

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