Renata Fagnani
State University of Campinas
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Featured researches published by Renata Fagnani.
Medical Mycology | 2013
Maria Luiza Moretti; Plínio Trabasso; Luzia Lyra; Renata Fagnani; Mariangela Ribeiro Resende; Luís Gustavo de Oliveira Cardoso; Angélica Zaninelli Schreiber
From 2006 to 2010, a retrospective study was conducted in a university referral tertiary care hospital to study the frequency and distribution of Candida species in different medical specialties. The use of mechanical ventilation, central venous catheter, and urinary catheter were recorded per 1,000 patient-days and the use of antifungals was calculated using defined daily dose (DDD). A total of 313 episodes were identified and the overall incidence was 0.54 (0.41-0.71) episodes per 1,000 patient-days. Candida albicans caused 44% of the overall episodes, followed by C. tropicalis (21.7%), C. parapsilosis (14.4%), C. glabrata (11.2%), and C. krusei (3.5%). The incidence of C. glabrata significantly increased from 2006-2010 (range: 4.8-23.5%) (P = 0.024). Candida glabrata was associated with malignancies (P = 0.004) and C. krusei with hematologic malignancies (P < 0.0001). The use of antifungals was higher in the hematology/bone marrow transplant units and represented 40% of all fluconazole prescription in the hospital. There was no correlation with the use of fluconazole and the increasing ratio of C. glabrata (r = 0.60). The use of invasive devices was significantly higher in the intensive care units (ICUs) than the medical and surgical emergencies units (P < 0.001). In contrast, the emergencies had higher incidence of candidemia (2-2.1 episodes/1,000 patient-days) than the ICUs (1.6 episodes 1,000 patient-days). Candida glabrata candidemia showed a significant increase in contrast to the current national literature where C. parapsilosis remained the most important non-C. albicans Candida species in Brazilian hospitals. Our findings suggested that the increasing incidence of C. glabrata was not associated with use of fluconazole and other risk factors might play an important role.
Revista Da Sociedade Brasileira De Medicina Tropical | 2012
Flávia Alves Ferreira Rossini; Renata Fagnani; Mirtes Loeschner Leichsenring; Sônia Regina Pérez Evangelista Dantas; Luís Gustavo de Oliveira Cardoso; Carlos Emílio Levy; Maria Luiza Moretti; Plínio Trabasso
INTRODUCTION Vancomycin-resistant enterococci (VRE) can colonize or cause infections in high-risk patients and contaminate the environment. Our objective was to describe the epidemiological investigation of an outbreak of VRE, the interventions made, and their impact on its control. METHODS We conducted a retrospective, descriptive, non-comparative study by reviewing the charts of patients with a VRE-positive culture in the University Hospital of Campinas State University, comprising 380 beds, 40 of which were in intensive care units (ICUs), who were admitted from February 2008-January 2009. Interventions were divided into educational activity, reviewing the workflow processes, engineering measures, and administrative procedures. RESULTS There were 150 patients, 139 (92.7%) colonized and 11 (7.3%) infected. Seventy-three percent were cared for in non-ICUs (p = 0.028). Infection was more frequent in patients with a central-line (p = 0.043), mechanical ventilation (p = 0.013), urinary catheter (p = 0.049), or surgical drain (p = 0.049). Vancomycin, metronidazole, ciprofloxacin, and third-generation cephalosporin were previously used by 47 (31.3%), 31 (20.7%), 24 (16%), and 24 (16%) patients, respectively. Death was more frequent in infected (73%) than in colonized (17%) patients (p < 0.001). After the interventions, the attack rate fell from 1.49 to 0.33 (p < 0.001). CONCLUSIONS Classical risk factors for VRE colonization or infection, e.g., being cared for in an ICU and previous use of vancomycin, were not found in this study. The conjunction of an educational program, strict adhesion to contact precautions, and reinforcement of environmental cleaning were able to prevent the dissemination of VRE.
Open Forum Infectious Diseases | 2014
Luís Gustavo de Oliveira Cardoso; Renata Fagnani; Mirtes Loeschner Leichsenring; Sônia Regina Pérez Evangelista Dantas; Luis Felipe Bachur; Christian Hoffling; Plínio Trabasso; Maria Luiza Moretti
BACKGROUND Several strategies have been implemented to control VRE in hospital outbreaks. The delay in time for detecting the initial VRE colonization/infection may lead to a huge hospital dissemination. A major goal in healthcare facilities has been to stop VRE transmission. VRE was first isolated in our hospital in June 2007, from a urine culture of a patient from the gastroenterology clinic with an advanced stage of cirrhosis. From 2007 to 2009, a VRE outbreak in our hospital was controlled with: active surveillance of rectal swabs, isolation of colonized/infected patients, barrier precautions and antibiotic policies . Since 2009, protocols of control measures have been continuously implemented. This study evaluated the impact of maintaining the protocols for controlling VRE colonization/infection during the period of 2010 to July 2014 compared to the study done in 2007 to 2009
European Journal of Clinical Microbiology & Infectious Diseases | 2011
Maria Luiza Moretti; L. G. de Oliveira Cardoso; Carlos Emílio Levy; A. Von Nowakosky; Luis Felipe Bachur; O.J. Bratfich; Mirtes Loeschner Leichsenring; Renata Fagnani; S. M. Peres Evangelista Dantas; Mariângela Ribeiro Resende; Plínio Trabasso
Mycopathologia | 2015
Plínio Trabasso; Tetsuhiro Matsuzawa; Renata Fagnani; Yasunori Muraosa; Kenichiro Tominaga; Mariangela Ribeiro Resende; Katsuhiko Kamei; Yuzuru Mikami; Angélica Zaninelli Schreiber; Maria Luiza Moretti
BIS. Boletim do Instituto de Saúde (Impresso) | 2013
Eliane Molina Psaltikidis; Marcelo A. Oliveira; Edson Luiz Kitaka; Mirtes Loeschner Leichsenring; Renata Fagnani; Jacques Gama; Cláudia C. M. Santos; Joicilene Oliveira Luciano; Manoel Barros Bertolo
Infectious diseases | 2015
Renata Fagnani; Mariângela Ribeiro Resende; Plínio Trabasso; Yuzuru Mikami; Angélica Zaninelli Schreiber; Ariane Fidelis Busso Lopes; Yasunori Muraosa; Katsuhiko Kamei; Maria Luiza Moretti
Value in Health | 2017
Eliane Molina Psaltikidis; Resende; Kp Mattos; Mirtes Loeschner Leichsenring; Renata Fagnani; Tc Lima; Luís Gustavo de Oliveira Cardoso; Luis Felipe Bachur; Christian Cruz Hofling; Maria Luiza Moretti
Value in Health | 2017
Sr Dantas; Renata Fagnani; Tc Lima; Va Silva; Mo Azevedo; Gc Bueno; Ap Gadanhoto; Ap Oliveira; Eliane Molina Psaltikidis; D Carrara; Resende
Archive | 2015
Renata Fagnani; Mariângela Ribeiro Resende