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Featured researches published by Renata Tucci.


Pesquisa Odontológica Brasileira | 2003

Homeobox genes: a molecular link between development and cancer

Fabio Daumas Nunes; Fernanda Almeida; Renata Tucci; Suzana Cantanhede Orsini Machado de Sousa

Homeobox genes are regulatory genes encoding nuclear proteins that act as transcription factors, regulating aspects of morphogenesis and cell differentiation during normal embryonic development of several animals. Vertebrate homeobox genes can be divided in two subfamilies: clustered, or HOX genes, and nonclustered, or divergent, homeobox genes. During the last decades, several homeobox genes, clustered and nonclustered ones, were identified in normal tissue, in malignant cells, and in different diseases and metabolic alterations. Homeobox genes are involved in the normal teeth development and in familial teeth agenesis. Normal development and cancer have a great deal in common, as both processes involve shifts between cell proliferation and differentiation. The literature is accumulating evidences that homeobox genes play an important role in oncogenesis. Many cancers exhibit expression of or alteration in homeobox genes. Those include leukemias, colon, skin, prostate, breast and ovarian cancers, among others. This review is aimed at introducing readers to some of the homeobox family functions in normal tissues and especially in cancer.


Annals of Diagnostic Pathology | 2003

Comparative immunoprofile of polymorphous low-grade adenocarcinoma and canalicular adenoma

Cristiane Furuse; Renata Tucci; Suzana Cantanhede Orsini Machado de Sousa; Yasmin Rodarte Carvalho; Vera Cavalcanti de Araújo

Immunohistochemistry is an important tool when dealing with salivary gland neoplasms. Canalicular adenoma and polymorphous low-grade adenocarcinoma may share some histologic characteristics that can cause difficulties in their separation. In the present study, cases of polymorphous low-grade adenocarcinoma and canalicular adenoma were submitted to a panel of antibodies to evaluate the differences in their immunoprofiles. The results obtained showed that, while vimentin is only expressed by polymorphous low-grade adenocarcinoma, CK7 and CK8 are present in both neoplasms. Therefore, vimentin is the best marker to differentiate between these tumors.


Journal of Applied Oral Science | 2011

HOXB5 expression in oral squamous cell carcinoma

Renata Tucci; Marcia Sampaio Campos; Luciana Fasanella Matizonkas-Antonio; Marcelo Doria Durazzo; Décio dos Santos Pinto Júnior; Fabio Daumas Nunes

UNLABELLED Human HOX genes encode transcription factors that act as master regulators of embryonic development. They are important in several processes such as cellular morphogenesis and differentiation. The HOXB5 gene in particular has been reported in some types of neoplasm, but not in oral cancer. OBJECTIVE The present study investigated the expression of HOXB5 in oral squamous cell carcinoma (SCC) and in non-tumoral adjacent tissues, focusing on verifying its possible role as a broad tumor-associated gene and its association with histopathological and clinical (TNM) characteristics. MATERIAL AND METHODS RT-PCR was performed to amplify HOXB5 mRNA in 15 OSCCs and adjacent non-tumoral epithelium. A possible association with TNM and histopathologic data was verified by the chi-square and post-hoc t-test. RESULTS HOXB5 was amplified in 60% non-tumoral epithelium and in 93.3% carcinomas. No statistically significant differences were found regarding the HOXB5 mRNA expression and TNM or histological grade. CONCLUSION HOXB5 is expressed in OSCCs and its role in cancer progression should be further investigated.


RPG rev. pos-grad | 2002

Extraçäo rápida de DNA para uso no diagnóstico histopatológico e estudos retrospectivos: comparaçäo de quatro métodos

Luciana Fasanella Matizonkas; Ricardo Alves Mesquita; Renata Tucci; Fabio Daumas Nunes


Oral Surgery, Oral Medicine, Oral Pathology, and Oral Radiology | 2018

Clear Cell Odontogenic Carcinoma: a Clinical Case Report

Lívia Ramalho Crescencio; Juliana Da Costa Oliveira; Maria Carolina de Lima Jacy Monteiro Barki; Vera Cavalcanti de Araújo; Rebeca De Souza Azevedo; Renata Tucci


Oral Surgery, Oral Medicine, Oral Pathology, and Oral Radiology | 2018

Recurrent Herpes Labialis Successfully Treated with Antimicrobial Photodynamic Therapy: Two Case Reports

Karla Bianca Fernandes Da Costa Fontes; Rafaela Elvira Rozza-De-Menezes; Maria Carolina De Lima Jacy Monteiro; Rebeca De Souza Azevedo; Pedro Arthur Da Silva Ramos; Renan Baere De Sá Oliveira; Renata Tucci


Oral Surgery, Oral Medicine, Oral Pathology, and Oral Radiology | 2018

Can Two Years of Use of Topical Triamcinolone Acetonide Induce Oral Candidiasis

Pedro Arthur Da Silva Ramos; Tamires Thadeu Coelho; Rafaela Elvira Rozza-De-Menezes; Maria Carolina De Lima Jacy Monteiro; Renata Tucci; Renan Baere De Sá Oliveira; Karla Bianca Fernandes Da Costa Fontes


Oral Surgery, Oral Medicine, Oral Pathology, and Oral Radiology | 2018

Demographic, Clinical, and Microscopic Findings of Biopsies From the Oral Cavity: a 6-Year Retrospective Study

Amanda Simões Santos; João Figueira Scarini; Adriele Ferreira Gouvêa; Renata Tucci; Karla Bianca Fernandes Da Costa Fontes; Rafaela Elvira Rozza-De-Menezes; Rebeca De Souza Azevedo


Oral Surgery, Oral Medicine, Oral Pathology, and Oral Radiology | 2018

High Recurrence Rate of Oral Ulcers of Unknown Cause: a Challenging Clinical Case

Philippe Moreira; Ademar Takahama Junior; Adriele Ferreira Gouvêa; Karla Bianca Fernades Da Costa Fontes; Renata Tucci; Rebeca De Souza Azevedo; Rafaela Elvira Rozza-De-Menezes


Oral Surgery, Oral Medicine, Oral Pathology, and Oral Radiology | 2018

Immunohistochemical Expression of Matrix Metalloproteinases in Actinic Cheilitis According to Epithelial Dysplasia

Juliana Costa de Oliveira; Pricilla Rodrigues Câmara; Renata Tucci; Karla Bianca Fernandes Da Costa Fontes; Ademar Takahama Junior; Rebeca De Souza Azevedo

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