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Featured researches published by Renata Zajączkowska.


Neurologia I Neurochirurgia Polska | 2014

Diagnosis and management of neuropathic pain: review of literature and recommendations of the Polish Association for the study of pain and the Polish Neurological Society - part one.

Andrzej Szczudlik; Jan Dobrogowski; Jerzy Wordliczek; Adam Stępień; Małgorzata Krajnik; Wojciech Leppert; Jarosław Woroń; Anna Przeklasa-Muszyńska; Magdalena Kocot-Kępska; Renata Zajączkowska; Marcin Janecki; Anna Adamczyk; Małgorzata Malec-Milewska

Neuropathic pain may be caused by a variety of lesions or diseases of both the peripheral and central nervous system. The most common and best known syndromes of peripheral neuropathic pain are painful diabetic neuropathy, trigeminal and post-herpetic neuralgia, persistent post-operative and post-traumatic pain, complex regional pain syndrome, cancer-related neuropathic pain, HIV-related neuropathic pain and pain after amputation. The less common central pain comprises primarily central post-stroke pain, pain after spinal cord injury, central pain in Parkinson disease or in other neurodegenerative diseases, pain in syringomyelia and in multiple sclerosis. A multidisciplinary team of Polish experts, commissioned by the Polish Association for the Study of Pain and the Polish Neurological Society, has reviewed the literature on various types of neuropathic pain, with special focus on the available international guidelines, and has formulated recommendations on their diagnosis and treatment, in accordance with the principles of evidence-based medicine (EBM). High quality studies on the efficacy of various medicines and medical procedures in many neuropathic pain syndromes are scarce, which makes the recommendations less robust.


Pharmacological Reports | 2018

Tapentadol – A representative of a new class of MOR-NRI analgesics

Renata Zajączkowska; Barbara Przewlocka; Magdalena Kocot-Kępska; Joanna Mika; Wojciech Leppert; Jerzy Wordliczek

Tapentadol is a centrally acting analgesic with a dual mode of action as a μ-opioid receptor (MOR) agonist and a noradrenaline reuptake inhibitor (NRI). It was initially approved by the US Food and Drug Administration in November 2008 for the treatment of moderate-to-severe acute pain in adult patients, and in August 2011, for chronic pain in an prolonged release form in the same population. Due to its limited protein binding capacity, the absence of active metabolites and significant microsomal enzyme induction or inhibition, tapentadol has a limited potential for drug-drug interactions. It appears to be well-tolerated and effective in the treatment of moderate-to severe acute and chronic pain. Owing to its dual mechanism of action, it is hypothesized to be good option in the treatment of both nociceptive and neuropathic pain.


BÓL | 2018

Pharmacotherapy of pain in cancer patients– recommendations of the Polish Association for the Studyof Pain, Polish Society of Palliative Medicine, Polish Societyof Oncology, Polish Society of Family Medicine, and PolishSociety of Anaesthesiology and Intensive Therapy

Jerzy Wordliczek; Aleksandra Kotlińska-Lemieszek; Wojciech Leppert; Jarosław Woroń; Jan Dobrogowski; Małgorzata Krajnik; Anna Przeklasa-Muszyńska; Jacek Jassem; Jarosław Drobnik; Anna Wrzosek; Marcin Janecki; Jadwiga Pyszkowska; Magdalena Kocot-Kępska; Renata Zajączkowska; Iwona Filipczak-Bryniarska; Krystyna Boczar; Joanna Jakowicka-Wordliczek; Małgorzata Malec-Milewska; Andrzej Kübler; Marek Suchorzewski; Sylwester Mordarski

Guidelines for the pharmacotherapy of pain in cancer patients were developed by a group of 21 experts of the Polish Association for the Study of Pain, Polish Society of Palliative Medicine, Polish Society of Oncology, Polish Society of Family Medicine, and Polish Society of Anaesthesiology and Intensive Therapy. During a series of meetings, the experts carried out an overview of the available literature on the treatment of pain in cancer patients, paying particular attention to systematic reviews and more recent randomized studies not included in the reviews. The search was performed in the EMBASE, MEDLINE, and Cochrane Central Register of Controlled Trials databases using such keywords as “pain”, “cancer”, “pharmacotherapy”, “analgesics”, and similar. The overviewed articles included studies of pathomechanisms of pain in cancer patients, methods for the assessment of pain in cancer patients, and drugs used in the pharmacotherapy of pain in cancer patients, including non-opioid analgesics (paracetamol, metamizole, non-steroidal anti-inflammatory drugs), opioids (strong and weak), coanalgesics (glucocorticosteroids, α2-adrenergic receptor agonists, NMDA receptor antagonists, antidepressants, anticonvulsants, topical medications) as well as drugs used to reduce the adverse effects of the analgesic treatment and symptoms other than pain in patients subjected to opioid treatment. The principles of opioid rotation and the management of patients with opioidophobia were discussed and recommendations for the management of opioid-induced hyperalgesia were presented. Drugs used in different types of pain experienced by cancer patients, including neuropathic pain, visceral pain, bone pain, and breakthrough pain, were included in the overview. Most common interactions of drugs used in the pharmacotherapy of pain in cancer patients as well as the principles for the pharmacotherapy of pain in cancer patients with organ dysfunctions (circulatory failure, chronic obstructive pulmonary disease,


Polski Przegląd Neurologiczny | 2011

Patofizjologia i klasyfikacja bólu

Jan Dobrogowski; Renata Zajączkowska; Julian Dutka; Jerzy Wordliczek


Polski Przegląd Neurologiczny | 2011

Farmakologiczne leczenie bólu neuropatycznego

Jerzy Wordliczek; Renata Zajączkowska; Jan Dobrogowski


BÓL | 2018

Chronic pain – the idea of mechanism orientated treatment

Magdalena Kocot-Kępska; Renata Zajączkowska; Jan Dobrogowski; Anna Przeklasa-Muszyńska


Anestezjologia Intensywna Terapia | 2018

Postępowanie w bólu pooperacyjnym 2018 — stanowisko Sekcji Znieczulenia Regionalnego i Terapii Bólu Polskiego Towarzystwa Anestezjologii i Intensywnej Terapii, Polskiego Towarzystwa Znieczulenia Regionalnego i Leczenia Bólu, Polskiego Towarzystwa Badania Bólu oraz Konsultanta Krajowego w dziedzinie anestezjologii i intensywnej terapii

Hanna Misiołek; Renata Zajączkowska; Andrzej Daszkiewicz; Jarosław Woroń; Jan Dobrogowski; Jerzy Wordliczek; Radosław Owczuk


Anaesthesiology Intensive Therapy | 2018

Postoperative pain management — 2018 consensus statement of the Section of Regional Anaesthesia and Pain Therapy of the Polish Society of Anaesthesiology and Intensive Therapy, the Polish Society of Regional Anaesthesia and Pain Therapy, the Polish Association for the Study of Pain and the National Consultant in Anaesthesiology and Intensive Therapy

Hanna Misiołek; Renata Zajączkowska; Andrzej Daszkiewicz; Jarosław Woroń; Jan Dobrogowski; Jerzy Wordliczek; Radosław Owczuk


Palliative Medicine in Practice | 2017

Bone pain in cancer patients — what is known about its pathomechanisms?

Renata Zajączkowska; Wojciech Leppert; Jerzy Wordliczek


Palliative Medicine in Practice | 2017

Pharmacotherapy of neuropathic pain

Jerzy Wordliczek; Renata Zajączkowska; Wojciech Leppert

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Wojciech Leppert

Poznan University of Medical Sciences

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Magdalena Kocot-Kępska

Jagiellonian University Medical College

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Małgorzata Krajnik

Nicolaus Copernicus University in Toruń

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Andrzej Szczudlik

Jagiellonian University Medical College

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Andrzej Daszkiewicz

Medical University of Silesia

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Danuta Dyk

Poznan University of Medical Sciences

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