Ricardo Abrantes do Amaral

Avaliação de instrumento de detecção de problemas relacionados ao uso do álcool (CAGE) entre trabalhadores da prefeitura do campus da Universidade de São Paulo (USP) - campus capital

Alcohol intake may play a significant role in absenteeism, delays and accidents at the workplace. However, its detection is limited by difficulties of both patients and physicians regarding the subject. The CAGE questionnaire may be an easy, fast and non intimidative alternative to detect alcohol-related problems (ARP). OBJECTIVES: To evaluate the validity coefficients of the CAGE (sensitivity, Sen; specificity, Spec; positive predictive value, PPV, and the area under the ROC curve - AUC) among employees of the Campus of the University of Sao Paulo using the Structured Clinical Interview for DSM-IV, SCID 2.0. METHODS: A random 203-worker sample was selected to be surveyed with a socio-demographic questionnaire followed by the CAGE questions and the SCID 2.0. CAGE validity coefficients were analyzed according to the SCID 2.0 results for alcohol abuse and dependence, while sociodemographic data were analyzed by the chi-square test. RESULTS: Among 192 interviewed workers, the prevalence of the CAGE-positive was 19,8%. Validity coefficients results were for ARP: Sen=84,4%, Spec=93,1%, PPV=71,1% and AUC=0,88 (p<0,01); and for alcohol dependence: Sen=91,3%, Spec=89,9%, PPV=55,3% and AUC=0,90 (p<0,01). There were significant associations between CAGE-positive and the following characteristics: 1) age (61 years or more, p=0,04), 2) male gender (p=0,01) and 3) blue color occupations (p=0,02). CONCLUSION: The PPV of the CAGE suggested its better performance in screening ARP (abuse and dependence) than only alcohol dependence. The association with age and sex could be related to limitations of the questionnaire. Blue color occupations could indicate a risk factor for ARP. The CAGE was considered valid for the screening of ARP at the workplace.

Uso de substâncias na adolescência e problemas familiares

This study aimed to evaluate the association between substance use (alcohol, tobacco, and illicit drugs) and family problems among 965 adolescents from 50 public schools in two cities in Sao Paulo State, Brazil, in 2007. The Drug Use Screening Inventory (DUSI) was used for data collection. Use of alcohol, tobacco, and illicit drugs was associated with a negative assessment of the family relationship, lack of monitoring/support, and psychoactive substance use by family members (p < 0.05). Adolescents that reported having used alcohol, tobacco, and illicit drugs had more family problems than those who did not consume any substance (p < 0.001). Adolescents that used alcohol and tobacco (p = 0.028) and illicit drugs (p < 0.001) reported having more family problems than those who used only alcohol. The results highlight the importance of awareness of alcohol and tobacco use by adolescents, since such use was associated with significant family impairments, similar to illicit drug use.

Gender parity and drug use: are girls catching up with boys?

OBJECTIVE To evaluate the association between gender and use of alcohol, tobacco, and other drugs in adolescents aged 10 to 18 years in the municipalities of Jacareí and Diadema, São Paulo, Brazil. METHODS A total of 971 adolescents completed the Drug Use Screening Inventory (DUSI). RESULTS In our sample, 55% of adolescents were male, 33.8% reported having made use in the previous month of alcohol, 13.5% of cigarettes, and 6.4% of illicit drugs. There was no significant difference between genders in the use of alcohol, tobacco, and illicit drugs in any of the analysis (p > 0.05). The use of alcohol, tobacco, and illicit drugs was associated with the city, age, educational level, school failure, and relationship with parents (p < 0.05). CONCLUSIONS Substance abuse among adolescents in our sample seems to follow the recent global trend towards the equalization of drug use between genders. This result should be taken into account by public health professionals in developing policies for this problem.

Alcohol dependence and CD4 cell count: is there a relationship?

Alcohol and other drugs use seem to be common among people infected with HIV on antiretroviral treatment (ART). Their effects on HIV progression is still in debate. This study aimed to assess the association between alcohol and drug use and an HIV disease progression biomarker (CD4 cell count) among patients on ART. A cross-sectional study was carried out at an HIV treatment center affiliated with Medical School of the University of São Paulo, Brazil. Four hundred and thirty-eight HIV-positive patients on ART were interviewed by trained psychiatrists and psychologists using the following instruments: Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I), Alcohol Use Disorders Identification Test (AUDIT), 17-item Hamilton Rating Scale for Depression, and the Simplified Medication Adherence Questionnaire (SMAQ). In the previous month, 219 (50%) and 41 (9.3%) patients reported use of alcohol and illicit drugs, respectively. Fifty patients (12.6%) were classified as having harmful alcohol use by AUDIT. According to SCID-I, 80 patients (18.3%) were alcohol abusers, 24 (5.5%) alcohol dependents, and 21 (4.2%) had a current depressive disorder. Almost 73% (n = 319–72.8%) of the patients were adherent to ART. Alcohol dependents were nine times (p < 0.01) more likely to have CD4 cell count ≤200/mm3, and this association was independent of ART adherence. In conclusion, alcohol dependence seems to be associated with low CD4 cell count in HIV-positive patients. Based on these data, HIV health care workers should always assess alcohol consumption in the treatment setting, and patients should be advised that alcohol dependence may be linked to low CD4.

Motivational Interviewing combined with chess accelerates improvement in executive functions in cocaine dependent patients: A one-month prospective study

BACKGROUND In cocaine-dependent individuals, executive function (EF) deficits are associated with poor treatment outcomes. Psychological interventions and pharmacological approaches have produced only modest effect sizes. To date, studies of this topic have been few and limited. The aim of this study was to examine the effects of a new model of intervention, which integrates chess and Motivational Interviewing, Motivational Chess (MC) METHODS: We evaluated 46 cocaine-dependent inpatients (aged 18-45), in two groups-MC (n=26); and active comparison-AC (n=20). Using neuropsychological tests and an impulsivity scale, we assessed the subjects before and after the study period (one month of abstinence monitored by urine toxicology screening). RESULTS The MC and AC groups did not differ at baseline. In the post-intervention assessment (after one month), both groups showed significant improvements in attention, mental flexibility, inhibitory control, abstraction abilities, and decision-making (p<0.01). In addition, the improvement in working memory was more significant in the MC group than in the AC group (group-by-time interaction, p=01). CONCLUSIONS One month of abstinence was sufficient to improve various attentional and executive domains in cocaine-dependent subjects. The MC intervention was associated with greater improvements in EFs, especially working memory, suggesting that tailored interventions focusing on complex EFs accelerate the process of cognitive recovery during the initial period of abstinence.

Manejo do paciente com transtornos relacionados ao uso de substância psicoativa na emergência psiquiátrica

Objective: Substance use disorders are prevalent in the emergency departments of medical and psychiatric services, accounting for up to 28% of cases in medical emergency departments. However, emergency department professionals identify less than 50% of the cases of alcoholrelated problems. This article aims to provide evidence-based interventions for the specific treatment of patients who meet diagnostic criteria for substance use disorders and who present to emergency rooms during intoxication or withdrawal. Method: A literature review was performed on the Medline database, using the English descriptors “acute intoxication”, “withdrawal”, “alcohol”, “cocaine”, “cannabis”, “opioid”, “inhalant”, and “management”. Results and Conclusion: The management of patients with substance use disorders should include a comprehensive assessment (medical and psychiatric), treatment of diagnosed disorders (withdrawal, intoxication, and clinical features that characterize an emergency), awareness of the patient to start treatment if necessary, and referral.

The association between low alcohol use and traffic risk behaviors among Brazilian college students

Although there are a large number of studies focused on binge drinking and traffic risk behaviors (TRB), little is known regarding low levels of alcohol consumption and its association to TRB. The aim of this cross-sectional study is to examine the association of low to moderate alcohol intake pattern and TRB in college students in Brazil. 7037 students from a National representative sample were selected under rigorous inclusion criteria. All study participants voluntarily fulfilled a structured, anonymous, and self-questionnaire regarding alcohol and drug use, social-demographic data, and TRB. Alcohol was assessed according to the average number of alcoholic units consumed on standard occasions over the past 12 months. The associations between alcohol intake and TRB were summarized with odds ratio and their confidence interval obtained from logistic regression. Compared with abstainers students who consumed only one alcohol unit had the risk of being a passenger in a car driven by a drunk driver increased by almost four times, students who reported using five or more units were increased by almost five times the risk of being involved in a car crash. Compared with students who consumed one alcohol unit, the risk of driving under the influence of alcohol increased four times in students using three alcohol units. Age group, use of illicit drugs, employment status, gender, and marital status significantly influenced occurrence of TRB among college students. Our study highlights the potential detrimental effects of low and moderate pattern of alcohol consumption and its relation to riding with an intoxicated driver and other TRB. These data suggest that targeted interventions should be implemented in order to prevent negative consequences due to alcohol use in this population.

Effectiveness of the CAGE questionnaire, gamma-glutamyltransferase and mean corpuscular volume of red blood cells as markers for alcohol-related problems in the workplace

OBJECTIVE To evaluate the usefulness of gamma-glutamyltransferase (GGT) and mean corpuscular volume (MCV), as well as that of the CAGE questionnaire, in workplace screening for alcohol abuse/dependence. METHODS A total of 183 male employees were submitted to structured interviews (Structured Clinical Interview for DSM-IV 2.0 and CAGE questionnaire). Blood samples were collected. Diagnostic accuracy and odds ratio were determined for the CAGE, GGT and MCV. RESULTS The CAGE questionnaire presented the best sensitivity for alcohol dependence (91%; specificity, 87.8%) and for alcohol abuse (87.5%, specificity, 80.9%), which increased when the questionnaire was used in combination with GGT (sensitivity, 100% and 87.5%, respectively; specificity, 68% and 61.5, respectively). CAGE positive results and/or alterations in GGT were less likely to occur among employees not presenting alcohol abuse/dependence than among those presenting such abuse (OR for CAGE=13, p<0.05; OR for CAGE-GGT=11, p<0.05) or dependence (OR for CAGE=76, p<0.01; OR for GGT=5, p<0.01). Employees not presenting alcohol abuse/dependence were also several times more likely to present negative CAGE or GGT results. CONCLUSIONS The use short, simple questionnaires, combined with that of low-cost biochemical markers, such as GGT, can serve as an initial screening for alcohol-related problems, especially for employees in hazardous occupations. The data provided can serve to corroborate clinical findings.

The influence of depressive symptoms and substance use on adherence to antiretroviral therapy. A cross-sectional prevalence study

CONTEXT AND OBJECTIVE Adherence to antiretroviral treatment (ART) is not a stable condition, but is dynamic, like mental conditions. The aim of this study was to examine whether non-adherence to ART is related to demographic and immunological variables, substance use and presence of depressive symptoms. DESIGN AND SETTING This was a cross-sectional prevalence study carried out at a public AIDS treatment center in the city of São Paulo, Brazil, between July 2006 and January 2007. METHODS 438 patients on regular ART schedules with recent laboratory tests answered a demographic questionnaire, questions about substance use, the Hamilton Depression Rating Scale (HDRS) and the Simplified Medication Adherence Questionnaire (SMAQ). RESULTS The prevalence of non-adherence over the past three months (a pattern of treatment interruption) was 46.3%, and 27.2% also reported this in the past week (a pattern of missed doses). ART interruption was significantly related to older age, lower CD4+ cell count and homosexual/bisexual transmission. The pattern of missed doses was significantly related to younger age, higher HDRS scores and higher viral load of RNA HIV. CONCLUSION ART interruption may reflect recall errors and changes to the Brazilian demographic characteristics of HIV infection. The missed doses may reflect lifestyle characteristics of younger individuals. Attendance for HIV-positive individuals, particularly younger patients, should involve interventions and counseling in relation to the presence of depressive symptoms.

The DSM-5 and the diagnosis of substance use disorders: Reflection about validity of the new criteria and possible 'missing pieces' in the puzzle.

Australian & New Zealand Journal of Psychiatry, 49(10) men, presenting in metropolitan outdoor areas, and involved police co-attendance, compared with nondrug-related attendances. In addition, significantly more individuals with non-drug-related psychosis had a selfreported past history of psychosis, and had presentations that involved self-harm. These findings demonstrate that a proportion of individuals who use stimulants may develop transient psychotic symptoms that require intervention by acute health services. While previous studies have identified that the presenting symptoms of stimulant-related psychosis may be indistinguishable from non-drug-related psychosis (Hermens et al., 2009), these data do demonstrate a number of socio-demographic factors that differ between the two types of acute presentations. Acknowledgements