Ricardo F. Borghelli

Oral lichen planus in patients with diabetes: An epidemiologic study

The prevalence of oral lichen planus was studied in 729 persons with diabetes and was found to be in 0.55% of cases. This result was compared with the results obtained from a group of controls without diabetes and from a sample of the general population of similar age and sex distribution. No statistical differences were observed.

Periodontal Changes and Dental Caries in Experimental Prediabetes

The prevalence, activity and rate of progression of dental caries, as well as the periodontal histopathology (presence or absence of pathological pockets, structure and thickness of the osseous alveolar crest, and width of the marginal periodontal ligament) in prediabetic and diabetic white rats were studied. The observations of caries activity (within the prediabetic period) were made on rats sacrificed forty-five days after being 95 per cent and 80 per cent pancreatectomized. A significant increment of caries activity was found in all aspects investigated in both groups of experimental animals with respect to normal and sham operated controls. The histopathology of the periodontium of 95 per cent pancreatectomized rats sacrificed ten months after the operation with diabetes of several months and varying degrees of hyperglycemia showed morphological alterations of the osseous alveolar crest, with significant thickening of the marginal periodontal ligament. This process could be observed very early in prediabetes in rats with normal blood sugar, no glycosuria, and normal diuresis and body weight, sacrificed three months after the operation. Even though it seems to be indisputable that alterations of carbohydrate metabolism in diabetic rats have an aggravating effect, changes in prediabetes suggest that the observed caries and lesions of the periodontium start very early and independently of the diabetic changes in carbohydrate metabolism.

Dental Caries in Diabetic and Prediabetic Rats

SYNOPSIS IN INTERLINGUA CARIE DENTAL IN RATTOs DiABETic E PREDIABETIC.—Le prevalentia, incidentia, e rapiditate evolutive de carie dental esseva studiate a base de un registration del numero de afficite e destruite dentes molar e de cavitates, si ben como del typo de carie incontrate. Un convenibile indice esseva applicate pro exprimer le grado de susceptibilitate. Statos diabetic e prediabetic esseva provocate per pancreatectomia a 95 pro cento, controlate per determinationes periodic del sucro sanguinee in stato jejun. Le condition diabetic accelerava notabilemente le establite processo de carie. Un augmento significative in le prevalentia, le incidentia, e le rapiditate evolutive esseva observate non solmente in animales con confirmate e incipiente diabete sed precocemente etiam in animales prediabetic.

Focal epithelial hyperplasia: Report of five new cases from Argentina

Five cases of focal epithelial hyperplasia in Argentina from 1968 to 1974 are reported. There was an age range from 11 to 27 years, with an average of 18 years. Three of the patients were born in Jujuy in the northwest corner of the country. Two of these cases were observed in an epidemiologic study carried out among 8,895 20-year-old Argentine men from different areas.

Effect of Insulin on Caries Activity in the Rat

The effect of insulin on dental caries in pancreatectomized and nonpancreatectomized white rats was studied. The experimental rats were pancreatectomized to 95%. All rats were killed 30 days after the operation and autopsies were performed on both experimental and control rats. The results showed a significant decrease of caries activity in nonpancreatectomized rats injected with insulin, as compared with the activity in normal controls; increased caries activity in pancreatectomized rats; and suppression of the cariogenic effect of pancreatectomy by insulin that was in direct relation to the dose of insulin.