Ricardo Lanzetta Haack

Queimadura solar em jovens: estudo de base populacional no Sul do Brasil

OBJETIVO: Analisar a prevalencia e fatores de risco para queimadura solar em jovens com idade entre 10 e 29 anos. METODOS: Estudo transversal de base populacional com amostragem em multiplos estagios, realizado com residentes da zona urbana de Pelotas, Rio Grande do Sul, entre os meses de outubro e dezembro de 2005. Para a coleta de dados foram feitas entrevistas com 1.604 individuos, utilizando questionario padronizado e pre-codificado com informacoes sobre a familia e outro questionario aos individuos com idade entre dez e 29 anos para avaliacao da ocorrencia de episodios de queimadura solar. Queimadura solar foi definida como ardencia na pele apos exposicao ao sol. Para as comparacoes entre proporcoes, utilizou-se teste do qui-quadrado com correcao de Yates. Na analise multivariada utilizou-se a regressao de Poisson com controle para efeito de delineamento e ajuste robusto da variância. RESULTADOS: Das pessoas com idade entre 10 e 29 anos, 1.412 relataram exposicao ao sol no ultimo verao. As perdas e recusas somaram 5,5%. Queimadura solar no ultimo ano foi relatada por 48,7% dos entrevistados. As variaveis associadas a ocorrencia de queimadura segundo a analise multivariada foram: cor da pele branca (RP=1,41; IC 95%: 1,12;1,79), maior sensibilidade da pele quando exposta ao sol (RP=1,84; IC 95%: 1,64;2,06), idade entre 15 e 19 anos (RP=1,30; IC 95%: 1,12;1,50), pertencer ao quartil de maior renda (RP=1,20; IC 95%: 1,01;1,42) e fazer uso irregular de fotoprotetor (RP=1,23; IC 95%: 1,08;1,42). CONCLUSOES: A prevalencia de queimadura solar na populacao estudada foi alta, principalmente entre jovens, de pele branca, com maior sensibilidade da pele, de maior renda e que faziam uso irregular de fotoprotetor. A exposicao solar em horarios seguros e com metodos de protecao adequados deve ser estimulada.

The hypertriglyceridemic waist phenotype in young adults from the Southern Region of Brazil

The present study aimed to assess the prevalence of the hypertriglyceridemic waist phenotype and its associated factors among subjects that have been followed up from birth. In 1982, all maternity hospitals in the city of Pelotas, in the Southern Region of Brazil, were visited and all births were recorded. Babies whose parents lived in the urban area of Pelotas were subsequently followed up on several occasions. A 22 to 23-year follow-up of this birth cohort was carried out in 2004 and 2005. The presence of the hypertriglyceridemic waist phenotype was defined as waist circumference ≥ 90 cm and triglyceride levels ≥ 177 mg/dL for males, and waist circumference ≥ 85 cm and triglyceride levels ≥ 133 mg/dL for females. The prevalence of the hypertriglyceridemic waist phenotype was 5.9% and 4.5% among men and women, respectively. Among males, a sedentary lifestyle during leisure time, smoking and obesity were associated with the presence of the hypertriglyceridemic waist phenotype, whereas among females the condition was positively associated with skin color, family income, obesity and dietary fat intake.El presente estudio tuvo como objetivo determinar la prevalencia del fenotipo de la cintura hipertrigliceridemica y sus factores asociados entre individuos que fueron observados desde su nacimiento. En 1982, las maternidades de Pelotas, sur de Brasil, fueron visitadas y todos los nacimientos fueron identificados. En 2004-2005, se decidio realizar un seguimiento de toda la cohorte. La presencia del fenotipo de la cintura hipertrigliceridemica se definio como una circunferencia de la cintura ≥ 90cm y trigliceridos ≥ 177mg/dL para el sexo masculino y circunferencia de la cintura ≥ 85cm y trigliceridos ≥ 133mg/dL para las mujeres. La prevalencia del fenotipo de la cintura hipertrigliceridemica fue de un 5,9% y un 4,5% entre los hombres y mujeres, respectivamente. Para los hombres, el sedentarismo en el ocio, tabaquismo y obesidad estuvo asociado con el fenotipo de la cintura hipertrigliceridemica. Por otro lado, entre las mujeres, el fenotipo de la cintura hipertrigliceridemica fue positivamente asociado con el color de la piel, renta familiar, obesidad y consumo de grasa.

TP53 gene polymorphism: Importance to cancer, ethnicity and birth weight in a Brazilian cohort

Arg72Pro SNP of p53 has been associated with many types of cancer as well as with survival and longevity. We evaluated the Arg72Pro SNP frequencies of a Brazilian birth cohort and their association with current, demographic and birth epidemiological parameters available. In 1982, all hospital births of Pelotas, southern Brazil, were identified and studied prospectively. In 2004–5, blood samples were collected and DNA extracted. PCR-RFLP was used to genotype the Arg72Pro SNP in 3794 individual samples of the Brazil birth cohort and DNA sequencing was performed to confirm the genotypes. The genotype distribution, which was in Hardy–Weinberg equilibrium, showed a predominance of the arginine amino acid with a frequency of 46.9% Arg/Arg, 42.2% Arg/Pro and 10.9% Pro/Pro. The allele frequency was 0.68 of Arginine and 0.32 of Proline. The Arg72Pro SNP genotype and allelic frequency were related to skin colour where proline amino acid was observed more among black subjects, while arginine amino acid was observed more among white subjects. The individuals without family history of cancer and those with low birth weight were associated with arginine amino acid. The Arg72Pro SNP was strongly associated with important epidemiological variables confirming that genetic profiles on cohort studies can improve our understanding of the susceptibility of diseases and its risk factors.

Prevalence of sun exposure and its associated factors in southern Brazil: a population-based study

BACKGROUND Sunlight exposure is responsible for a large number of dermatological diseases. OBJECTIVE We estimated the prevalence of sunlight exposure and its associated factors in adults from southern Brazil in a cross-sectional, population-based study. METHODS We investigated a representative sample of individuals aged ≥ 20 years (n=3,136). Sunlight exposure and its associated factors were evaluated in two distinct situations: at leisure time and at work. The time period investigated ranged from December 2004 to March 2005, comprising 120 days of the highest ultraviolet index in the urban area of the city of Pelotas, in southern Brazil. The participants were asked about sunlight exposure for at least 20 minutes between 10 A.M. and 4 P.M. The analysis was stratified by sex, and sunlight exposure was grouped into five categories. RESULTS Among the 3,136 participants, prevalence of sunlight exposure at the beach was 32.8% (95% CI, 30.3 - 35.2) and 26.3% (95% CI, 24.2 28.3) among men and women, respectively. The prevalence at work was 39.8% (95% CI, 37.2 - 42.4) among men and 10.5% (95% CI, 9.1 - 12.0) among women. Age was inversely associated with sunlight exposure. Family income and achieved schooling were positively associated with sunlight exposure at leisure time and inversely associated with sunglight exposure at work. Self-reported skin color was not associated. Knowledge of any friend or relative who has been affected by skin cancer was positively associated with sunlight exposure among men at work. CONCLUSION Despite the media campaigns on the harmful effects of excessive sunlight exposure, we found a high prevalence of sunlight exposure during a period of high ultraviolet index.

Hypertriglyceridemic Waist Phenotype: Effect of Birthweight and Weight Gain in Childhood at 23 years old.

Objective To evaluate the association of birthweight and weight gain during different periods in childhood with the prevalence of hypertriglyceridemic waist phenotype (HWP). Methods In 1982, all hospitals births in Pelotas, South Brazil, were identified, and the 5914 liveborn were examined and their mothers interviewed. This population has been followed for several times. In 2004–05, we tried to follow the whole cohort and the subjects were interviewed, examined, and a blood sample was collected. HWP was defined as a triglycerides ≥ 2 mmol/L and a waist circumference ≥ 90 cm for men, and triglycerides ≥ 1.5 mmol/L and waist circumference ≥ 85 cm for woman. Poisson regression with robust adjustment of the variance was used to obtain adjusted estimates of the prevalence ratio. Results Subjects whose weight-for-age z-score at mean age of 42 months was one or more standard deviation above the mean, according to gender and age, were 8.77 (95% confidence interval: 2.60; 29.64) times more likely of presenting the HWP than those subjects whose weight-for-age z-score at 42 months was more than one standard deviation below the mean. Among those subjects whose birthweight was adequate-for-gestational age (AGA), conditional weight at 20 months was positively associated to the risk of HWP [relative risk: 1.59 (95%: confidence interval: 1.32; 1.92)], whereas for small for gestational age (SGA) subjects conditional weight was not associated with HWP [relative risk: 1.05 (95% confidence interval: 0.77; 1.43)], p-value for interaction 0.08. Conclusion Early weight gain among SGA infants, did not increase the risk of HWP in early adulthood, whereas among those who were AGA, early weight gain increased the risk of the having the phenotype in early adulthood.

Cintura hipertrigliceridémica en adultos jóvenes en el sur de Brasil

The present study aimed to assess the prevalence of the hypertriglyceridemic waist phenotype and its associated factors among subjects that have been followed up from birth. In 1982, all maternity hospitals in the city of Pelotas, in the Southern Region of Brazil, were visited and all births were recorded. Babies whose parents lived in the urban area of Pelotas were subsequently followed up on several occasions. A 22 to 23-year follow-up of this birth cohort was carried out in 2004 and 2005. The presence of the hypertriglyceridemic waist phenotype was defined as waist circumference ≥ 90 cm and triglyceride levels ≥ 177 mg/dL for males, and waist circumference ≥ 85 cm and triglyceride levels ≥ 133 mg/dL for females. The prevalence of the hypertriglyceridemic waist phenotype was 5.9% and 4.5% among men and women, respectively. Among males, a sedentary lifestyle during leisure time, smoking and obesity were associated with the presence of the hypertriglyceridemic waist phenotype, whereas among females the condition was positively associated with skin color, family income, obesity and dietary fat intake.El presente estudio tuvo como objetivo determinar la prevalencia del fenotipo de la cintura hipertrigliceridemica y sus factores asociados entre individuos que fueron observados desde su nacimiento. En 1982, las maternidades de Pelotas, sur de Brasil, fueron visitadas y todos los nacimientos fueron identificados. En 2004-2005, se decidio realizar un seguimiento de toda la cohorte. La presencia del fenotipo de la cintura hipertrigliceridemica se definio como una circunferencia de la cintura ≥ 90cm y trigliceridos ≥ 177mg/dL para el sexo masculino y circunferencia de la cintura ≥ 85cm y trigliceridos ≥ 133mg/dL para las mujeres. La prevalencia del fenotipo de la cintura hipertrigliceridemica fue de un 5,9% y un 4,5% entre los hombres y mujeres, respectivamente. Para los hombres, el sedentarismo en el ocio, tabaquismo y obesidad estuvo asociado con el fenotipo de la cintura hipertrigliceridemica. Por otro lado, entre las mujeres, el fenotipo de la cintura hipertrigliceridemica fue positivamente asociado con el color de la piel, renta familiar, obesidad y consumo de grasa.

Cintura hipertrigliceridêmica em adultos jovens no Sul do Brasil

The present study aimed to assess the prevalence of the hypertriglyceridemic waist phenotype and its associated factors among subjects that have been followed up from birth. In 1982, all maternity hospitals in the city of Pelotas, in the Southern Region of Brazil, were visited and all births were recorded. Babies whose parents lived in the urban area of Pelotas were subsequently followed up on several occasions. A 22 to 23-year follow-up of this birth cohort was carried out in 2004 and 2005. The presence of the hypertriglyceridemic waist phenotype was defined as waist circumference ≥ 90 cm and triglyceride levels ≥ 177 mg/dL for males, and waist circumference ≥ 85 cm and triglyceride levels ≥ 133 mg/dL for females. The prevalence of the hypertriglyceridemic waist phenotype was 5.9% and 4.5% among men and women, respectively. Among males, a sedentary lifestyle during leisure time, smoking and obesity were associated with the presence of the hypertriglyceridemic waist phenotype, whereas among females the condition was positively associated with skin color, family income, obesity and dietary fat intake.El presente estudio tuvo como objetivo determinar la prevalencia del fenotipo de la cintura hipertrigliceridemica y sus factores asociados entre individuos que fueron observados desde su nacimiento. En 1982, las maternidades de Pelotas, sur de Brasil, fueron visitadas y todos los nacimientos fueron identificados. En 2004-2005, se decidio realizar un seguimiento de toda la cohorte. La presencia del fenotipo de la cintura hipertrigliceridemica se definio como una circunferencia de la cintura ≥ 90cm y trigliceridos ≥ 177mg/dL para el sexo masculino y circunferencia de la cintura ≥ 85cm y trigliceridos ≥ 133mg/dL para las mujeres. La prevalencia del fenotipo de la cintura hipertrigliceridemica fue de un 5,9% y un 4,5% entre los hombres y mujeres, respectivamente. Para los hombres, el sedentarismo en el ocio, tabaquismo y obesidad estuvo asociado con el fenotipo de la cintura hipertrigliceridemica. Por otro lado, entre las mujeres, el fenotipo de la cintura hipertrigliceridemica fue positivamente asociado con el color de la piel, renta familiar, obesidad y consumo de grasa.

Síndrome de Chilaiditi associada a volvo de cólon sigmóide: relato de caso

INTRODUCTION: This study aims at reporting a case of Chilaiditi Syndrome associated to sigmoid colon volvulus. CASE REPORT: Male patient, white, 51 years old, arrives at an emergency hospital in Pelotas with complaints of stoping the elimination of gases, diffuse abdominal pain, increase of abdominal volume, gradual and progressive inappetence, accepting only liquid. He is diagnosed with mental retardation and a situation of intestinal constipation. An acute abdomen Rx highlighted a diffuse colon distension, suggestive of sigmoid volvulus with tranversum colon image between the liver and the diaphragm. The patient was submitted to exploratory laparotomy being highlighted sigmoid volvulus, diffuse megacolon and interposition of the transverse colon between the liver and the diaphragm. Subtotal colectomy with terminal ascending colon colostomy was proceeded. The patient evolved satisfactorily being discharged on the 9th day. DISCUSSION: The interposition of the colon between the liver and the diaphragmatic cupula (Chilaiditi syndrome) associated to sigmoid colon volvulus constitutes a rare cause of obstructive acute abdomen, though the sigmoid volvulus is one of the main causes of mechanic intestinal obstruction in Brazil. Usually a clinical treatment is done, although when associated to complications the treatment is surgical.