Ricardo Martins Oliveira Filho

Chronic use of indinavir in albino rat pregnancy (Rattus norvegicus albinus, Rodentia, Mammalia): biological assay.

Aim:  Assess possible adverse effects of the chronic use of indinavir during pregnancy in a rat model.

Maternal-fetal monitoring during dental procedure in patients with heart valve disease

BACKGROUND The effects of local dental anesthesia with lidocaine and epinephrine on cardiovascular parameters of pregnant women with heart valve diseases and their fetuses are not fully understood. OBJECTIVES To assess and analyze cardiotocographic, blood pressure and electrocardiographic parameters of pregnant women with rheumatic heart valve disease undergoing local anesthesia with 1.8mL of lidocaine 2% with or without epinephrine 1:100,000 during restorative dental treatment. METHODS Maternal ambulatory blood pressure and electrocardiographic monitoring as well as cardiotocography of 31 patients with rheumatic heart disease were performed between the 28th and 37th week of gestation. The patients were divided into two groups, those with or without vasoconstrictor. RESULTS A significant reduction in maternal heart rate was shown in both groups during the procedure in comparison with the other periods (p<0.001). Cardiac arrhythmia was observed in nine (29.0%) patients, of which seven (41.8%) were from the group of 17 pregnant women who received anesthesia plus epinephrine. No difference in maternal blood pressure was observed when periods or groups were compared (p>0.05). The same occurred (p>0.05) with the number of uterine contractions, baseline level and variability, and number of accelerations of fetal heart rate. CONCLUSION The use of 1.8mL of lidocaine 2% in combination with epinephrine was safe and efficient in restorative dental procedures during pregnancy in women with rheumatic heart valve disease.FUNDAMENTO: Los efectos de la anestesia local en odontologia con lidocaina y epinefrina, sobre los parametros cardiovasculares de gestantes portadoras de valvulopatias y sus conceptos, no son claros. OBJETIVO: Evaluar y analizar parametros de la cardiotocografia, de la presion arterial y electrocardiograficos de la gestante portadora de enfermedad valvular reumatica, al someterse a anestesia local con 1,8 ml de lidocaina 2% sin vasoconstrictor y con epinefrina 1:100.000, durante procedimiento odontologico restaurador. METODOS: Realizamos monitoreo ambulatorio de la presion arterial, electrocardiografia ambulatoria materna y cardiotocografia de 31 portadoras de cardiopatia reumatica, entre la 28a y la 37a semana de gestacion, divididas en dos grupos segun la presencia o no del vasoconstrictor. RESULTADOS: Se observo reduccion significativa de los valores de frecuencia cardiaca materna en los dos grupos, durante el procedimiento, al compararlo con los demas periodos (p 0,05). Lo mismo ocurrio (p > 0,05) con el numero de contracciones uterinas, nivel de variabilidad de la linea de base y numero de aceleraciones de la frecuencia cardiaca fetal. CONCLUSION: El uso de 1,8 ml de lidocaina 2% asociado a la adrenalina se mostro seguro y eficaz en procedimiento odontologico restaurador durante la gestacion de mujeres con cardiopatia valvular reumatica.

Monitorização materno-fetal durante procedimento odontológico em portadora de cardiopatia valvar

BACKGROUND The effects of local dental anesthesia with lidocaine and epinephrine on cardiovascular parameters of pregnant women with heart valve diseases and their fetuses are not fully understood. OBJECTIVES To assess and analyze cardiotocographic, blood pressure and electrocardiographic parameters of pregnant women with rheumatic heart valve disease undergoing local anesthesia with 1.8mL of lidocaine 2% with or without epinephrine 1:100,000 during restorative dental treatment. METHODS Maternal ambulatory blood pressure and electrocardiographic monitoring as well as cardiotocography of 31 patients with rheumatic heart disease were performed between the 28th and 37th week of gestation. The patients were divided into two groups, those with or without vasoconstrictor. RESULTS A significant reduction in maternal heart rate was shown in both groups during the procedure in comparison with the other periods (p<0.001). Cardiac arrhythmia was observed in nine (29.0%) patients, of which seven (41.8%) were from the group of 17 pregnant women who received anesthesia plus epinephrine. No difference in maternal blood pressure was observed when periods or groups were compared (p>0.05). The same occurred (p>0.05) with the number of uterine contractions, baseline level and variability, and number of accelerations of fetal heart rate. CONCLUSION The use of 1.8mL of lidocaine 2% in combination with epinephrine was safe and efficient in restorative dental procedures during pregnancy in women with rheumatic heart valve disease.FUNDAMENTO: Los efectos de la anestesia local en odontologia con lidocaina y epinefrina, sobre los parametros cardiovasculares de gestantes portadoras de valvulopatias y sus conceptos, no son claros. OBJETIVO: Evaluar y analizar parametros de la cardiotocografia, de la presion arterial y electrocardiograficos de la gestante portadora de enfermedad valvular reumatica, al someterse a anestesia local con 1,8 ml de lidocaina 2% sin vasoconstrictor y con epinefrina 1:100.000, durante procedimiento odontologico restaurador. METODOS: Realizamos monitoreo ambulatorio de la presion arterial, electrocardiografia ambulatoria materna y cardiotocografia de 31 portadoras de cardiopatia reumatica, entre la 28a y la 37a semana de gestacion, divididas en dos grupos segun la presencia o no del vasoconstrictor. RESULTADOS: Se observo reduccion significativa de los valores de frecuencia cardiaca materna en los dos grupos, durante el procedimiento, al compararlo con los demas periodos (p 0,05). Lo mismo ocurrio (p > 0,05) con el numero de contracciones uterinas, nivel de variabilidad de la linea de base y numero de aceleraciones de la frecuencia cardiaca fetal. CONCLUSION: El uso de 1,8 ml de lidocaina 2% asociado a la adrenalina se mostro seguro y eficaz en procedimiento odontologico restaurador durante la gestacion de mujeres con cardiopatia valvular reumatica.

Monitoreo maternofetal durante procedimiento odontológico en portadora de cardiopatía valvular

BACKGROUND The effects of local dental anesthesia with lidocaine and epinephrine on cardiovascular parameters of pregnant women with heart valve diseases and their fetuses are not fully understood. OBJECTIVES To assess and analyze cardiotocographic, blood pressure and electrocardiographic parameters of pregnant women with rheumatic heart valve disease undergoing local anesthesia with 1.8mL of lidocaine 2% with or without epinephrine 1:100,000 during restorative dental treatment. METHODS Maternal ambulatory blood pressure and electrocardiographic monitoring as well as cardiotocography of 31 patients with rheumatic heart disease were performed between the 28th and 37th week of gestation. The patients were divided into two groups, those with or without vasoconstrictor. RESULTS A significant reduction in maternal heart rate was shown in both groups during the procedure in comparison with the other periods (p<0.001). Cardiac arrhythmia was observed in nine (29.0%) patients, of which seven (41.8%) were from the group of 17 pregnant women who received anesthesia plus epinephrine. No difference in maternal blood pressure was observed when periods or groups were compared (p>0.05). The same occurred (p>0.05) with the number of uterine contractions, baseline level and variability, and number of accelerations of fetal heart rate. CONCLUSION The use of 1.8mL of lidocaine 2% in combination with epinephrine was safe and efficient in restorative dental procedures during pregnancy in women with rheumatic heart valve disease.FUNDAMENTO: Los efectos de la anestesia local en odontologia con lidocaina y epinefrina, sobre los parametros cardiovasculares de gestantes portadoras de valvulopatias y sus conceptos, no son claros. OBJETIVO: Evaluar y analizar parametros de la cardiotocografia, de la presion arterial y electrocardiograficos de la gestante portadora de enfermedad valvular reumatica, al someterse a anestesia local con 1,8 ml de lidocaina 2% sin vasoconstrictor y con epinefrina 1:100.000, durante procedimiento odontologico restaurador. METODOS: Realizamos monitoreo ambulatorio de la presion arterial, electrocardiografia ambulatoria materna y cardiotocografia de 31 portadoras de cardiopatia reumatica, entre la 28a y la 37a semana de gestacion, divididas en dos grupos segun la presencia o no del vasoconstrictor. RESULTADOS: Se observo reduccion significativa de los valores de frecuencia cardiaca materna en los dos grupos, durante el procedimiento, al compararlo con los demas periodos (p 0,05). Lo mismo ocurrio (p > 0,05) con el numero de contracciones uterinas, nivel de variabilidad de la linea de base y numero de aceleraciones de la frecuencia cardiaca fetal. CONCLUSION: El uso de 1,8 ml de lidocaina 2% asociado a la adrenalina se mostro seguro y eficaz en procedimiento odontologico restaurador durante la gestacion de mujeres con cardiopatia valvular reumatica.

Parâmetros endócrinos em ratos tratados cronicamente com extrato concentrado de Stevia rebaudiana (Bert.) Bertoni

The effects of active principles os Stevia rebaudiana (Bert.) Bertoni on some endocrine functions in rats were studied after chronic administration (60 days) of a concentrated aqueous extract of the leaves, starting at pre-pubertal age (25-30 days). The following measurements have been carried out: glicemia, T3 and T4serum levels, available T3 binding sites in plasma (T3R), [3H]R1881 binding to prostate cytosol, Zn content in prostate, testis, submaxillary gland and pancreas, and hydric content in testis and prostate. Also, it has been studied the curve of body weight gain and the final weight of testis, prostate, seminal vesicle, submaxillary gland and adrenal. Any significant difference between experimental and control groups were seen, except for the weigth of seminal vesicle which. It was concluded that pharmacological doses of active principles of S.rebaudiana chronically administered to rats did not elicit any fundamental alternation of the endocrine functions studied.