Richa Chauhan

Mucosal Melanoma of the Sino-nasal Tract - A Rare Case Report

Sino nasal malignant melanoma is a very aggressive and rare neoplasm of the head and neck region. Less than 2% of all mucosal melanomas originate from the sino-nasal region demanding a high index of suspicion to diagnose these tumours. The patients developing sino-nasal melanomas are usually in their sixties and seventies. These patients often present in an advanced stage due to its nature of rapid progression associated with non-specific symptoms. The present case report highlights a rare case of malignant melanoma of the maxillary sinus, involving orbit in a 56 years

Molecular subtyping of invasive breast cancer and its relation to common risk factors: a hospital based study

Background: Breast cancer is the most common cancer among Indian women. Majority of our patients do not have the traditional risk factors, and present in a locally advanced stage which progresses despite treatment. Studies have shown that it can be stratified in molecular subtypes by using a panel of immunohistochemical markers for estrogen, progesterone and HER 2neu receptor, which is closely related to its prognosis. Aim: This study was done to determine the prevalence of various molecular subtypes in our patients and its relation to various risk factors. Materials and Method: 446 breast cancer patients treated at Mahavir Cancer Sansthan, Patna from January 2015 toDecember 2015 were retrospectively analysed for their age, parity, history of breast feeding, menopausal status, height, weight, ER, PR & HER2neu receptor status. They were then classified in four molecular subgroups, Luminal A, Luminal B, Triple negative and HER2neu positive cancers and its relation to menopausal status and body mass index was analysed. Observations and Results: 68.38% patients were premenopausal with a mean age of 47.12 years. 24.38% patients were obese or overweight, with an average BMI of 22.38. Luminal A subtype followed by Triple Negative subtype was found in 37% and 29% of the patients respectively. The prevalence of Triple Negative subtype was more in premenopausal and overweight patients. Conclusion: Overall prevalence of triple negative subtype in our patient population is high esp. among premenopausal overweight patients.

DUCTAL CARCINOM A OF BREAST WITH EPITROCHLEAR LYMPH NODE METASTASIS : A RARE CASE REPORT.

Vasudha singh 1 , Vinita Trivedi 1 , Richa Chauhan 1 , Manashi ghosh 1 , Kaustav mandal 1 and Ravishwar Narayan 2 . 1. Department of Radiation Oncology, Mahavir Cancer Sansthan. 2. Department of Nuclear Medicine, Mahavir Cancer Sansthan. ...................................................................................................................... Manuscript Info Abstract ......................... ........................................................................ Manuscript History

Determinants of Survival of Cervical Cancer: A Hospital Based Study

Globally uterine cervix cancer is one of the leading causes of death in females due to cancer, especially in developing countries. The aim of the study was to analyse the survival as well as understanding various prognostic factors for survival in patients of carcinoma cervix presenting in our hospital. A total of 508 patients were evaluated in radiotherapy department of Mahavir Cancer Sansthan and Research centre Patna, Bihar who came for follow up between April 2015 to March 2016 after completion of radical radiotherapy. Out of 508 patients 3.54% (n 18), 71.65% (n 364), 22.83% (n 116) and 1.9% (n 10) patients presented in sage I, II, III and IV A respectively. 53.54% of patients belonged to age group of 35 to 50 years with Survival of 937 ± 53.49 days. 46.46% of the patients were more than 50 years age and their survival was 933.3 ± 57.12 days. The mean duration for overall survival for all cases evaluated was 957.4 ± 39.49 days. The mean duration for survival of stages I, II, III and IVA was 1186 ± 281.8 days, 960 ± 85.04 days, 945.1 ± 45.66 days and 765 ± 181.5 days respectively. Survival of patients having squamous cell carcinoma was 970 ± 42.89 days and that of adenocarcinoma was 669.5 ± 120 days and that of premenopausal and postmenopausal lady was 997.5 ± 79.28 and 940.1 ± 45.39 days respectively. It was evident from study that patients who presented in early stage had a better survival. There was no significant difference in survival of cervix cancer patients in different age groups while survival was greater in premenopausal cervical cancer patients.