Richard A. Orr

Unexpected Increased Mortality After Implementation of a Commercially Sold Computerized Physician Order Entry System

Objective. In response to the landmark 1999 report by the Institute of Medicine and safety initiatives promoted by the Leapfrog Group, our institution implemented a commercially sold computerized physician order entry (CPOE) system in an effort to reduce medical errors and mortality. We sought to test the hypothesis that CPOE implementation results in reduced mortality among children who are transported for specialized care. Methods. Demographic, clinical, and mortality data were collected of all children who were admitted via interfacility transport to our regional, academic, tertiary-care level children’s hospital during an 18-month period. A commercially sold CPOE program that operated within the framework of a general, medical-surgical clinical application platform was rapidly implemented hospital-wide over 6 days during this period. Retrospective analyses of pre-CPOE and post-CPOE implementation time periods (13 months before and 5 months after CPOE implementation) were subsequently performed. Results. Among 1942 children who were referred and admitted for specialized care during the study period, 75 died, accounting for an overall mortality rate of 3.86%. Univariate analysis revealed that mortality rate significantly increased from 2.80% (39 of 1394) before CPOE implementation to 6.57% (36 of 548) after CPOE implementation. Multivariate analysis revealed that CPOE remained independently associated with increased odds of mortality (odds ratio: 3.28; 95% confidence interval: 1.94–5.55) after adjustment for other mortality covariables. Conclusions. We have observed an unexpected increase in mortality coincident with CPOE implementation. Although CPOE technology holds great promise as a tool to reduce human error during health care delivery, our unanticipated finding suggests that when implementing CPOE systems, institutions should continue to evaluate mortality effects, in addition to medication error rates, for children who are dependent on time-sensitive therapies.

Intensive plasma exchange increases a disintegrin and metalloprotease with thrombospondin motifs-13 activity and reverses organ dysfunction in children with thrombocytopenia-associated multiple organ failure.

Background:Thrombocytopenia-associated multiple organ failure (TAMOF) is a poorly understood syndrome in critically ill children. A disintegrin and metalloprotease with thrombospondin motifs (ADAMTS-13), formerly known as von Willebrand factor (VWF) cleaving protease, is decreased in adults with VWF-mediated thrombotic microangiopathy, and intensive plasma exchange (PEx) both replenishes ADAMTS-13 and improves outcome in these patients. Objectives:To determine whether: 1) critically ill children with TAMOF syndrome have decreased ADAMTS-13 activity, 2) ADAMTS-13 activity correlates with platelet counts and VWF antigen, 3) the autopsies from patients who died with reduced ADAMTS-13 activity have VWF-rich microthrombi, and 4) intensive PEx will restore ADAMTS-13 activity and facilitate organ failure resolution. Design:First study: Observational. Second study:Randomized control trial. Setting:Single center university pediatric intensive care unit. Patients:First study: thirty-seven consecutive children (17 males and 20 females; ages ranging from 9 days to 23 years) identified with ≥2 organs dysfunction were enrolled. Seventy-six percent of these children had thrombocytopenia (platelet counts <100,000/mm3). Five additional critically ill children without MOF were also enrolled. In the second study, children with severe TAMOF (platelet counts <100,000/mm3 and >3 organ failure) were randomized to PEx or standard therapy. Primary physicians and parents agreed to enrollment in 10 of the 20 eligible patients with ages ranging from 1 year to 18 years. Five patients received PEx and 5 patients received standard therapy. Results:First study: children with TAMOF (n = 28) had decreased ADAMTS-13 activity, but similar plasminogen activator inhibitor-1 activity and prothrombin time compared to children with MOF without thrombocytopenia (n = 9, p < 0.05). All non-survivors (n = 7) had TAMOF, reduced ADAMTS-13 activity, and VWF-rich microvascular thromboses at autopsy. In the second study, PEx (n = 5, median 12 days, 4–28 days) restored ADAMTS-13 activity and organ function, compared to standard therapy (n = 5, p < 0.05). Conclusions:Children with TAMOF syndrome can have VWF-mediated thrombotic microangiopathy. Similar to adult experience, PEx can replenish ADAMTS-13 activity and reverse organ failure.

Intrahospital transport of critically ill pediatric patients

OBJECTIVES To determine the frequency of adverse events during intrahospital transport; to determine the requirement of therapeutic interventions during transport; to test the hypothesis that adverse events that occur during intrahospital transport are due to the transport process itself; and to determine the factors that predict the occurrence of adverse events and the requirement of major therapeutic interventions during transport. DESIGN A two-phase study in which data were prospectively collected. In phase I, we examined the occurrence rate of adverse events, the requirement for therapeutic interventions, and the factors that predicted adverse events and the requirement of therapeutic interventions. In phase II, we tested the hypothesis that adverse events during transport were due to the transport process itself. SETTING A 250-bed university childrens hospital with a 50-bed intensive care unit (ICU). PATIENTS Phase I of the study consisted of one hundred and eighty intrahospital transports in 139 patients. These transports included patients who were transferred: a) to the ICU from the operating room, emergency department, or the general ward; b) from the ICU to the operating room; and c) from the ICU for diagnostic or therapeutic procedures. Phase II of the study consisted of 89 transports in 85 patients. INTERVENTIONS None. MEASUREMENTS AND MAIN RESULTS Vital signs and oxygen saturation were measured before and during transport. In phase I, there were no adverse events in 23.9% of transports. There was a significant change in at least one physiologic variable in 71.7% of transports, and at least one equipment-related mishap in 10% of transports. At least one major intervention was performed in 13.9% of transports in response to physiologic deterioration or an equipment-related mishap. There were no arrests or deaths during transport. The requirement for a major procedure was 34.4% in mechanically ventilated patients vs. 9.5% in nonventilated patients. Logistic regression analysis showed that both pretransport Therapeutic Intervention Scoring System and the duration of transport were significantly associated with the requirement of a major intervention and physiologic deterioration, while only the duration of transport was associated with an equipment-related event. The age of the patient and the number of escorts accompanying the transport did not affect the frequency of adverse events. Before transport in phase II study patients, no patient became hypothermic, the changes in physiologic variables were always < 20%, and there was no change > or = 5% in oxygen saturation. Hypothermia occurred in 11.2% of transports. A > or = 20% change in heart rate (15.7%), blood pressure (21.3%), and respiratory rate (23.6%) was seen only during transport. A > 5% change in oxygen saturation (5.6%) was seen only during transport. CONCLUSIONS Serious physiologic deterioration occurs during intrahospital transport of critically ill children. Severity of illness and the duration of transport are associated with the occurrence of adverse events during transport. The team composition and equipment required on transport must be commensurate with the pretransport severity of illness and the anticipated duration of transport.

Mortality and Functional Morbidity After Use of PALS/APLS by Community Physicians

OBJECTIVES: To test the hypothesis that pediatric shock is a common cause of death and functional morbidity and that pediatric advanced life support (PALS)/advanced pediatric life support (APLS) resuscitation in the community hospital setting improves child health outcomes. METHODS: This study included all children consecutively transported to 5 regional, tertiary care childrens hospitals over 4 years, and is a prospective cohort study comparing outcomes in children who did or did not receive PALS/APLS resuscitation in the community hospital. RESULTS: Shock occurred in 37% of the patients transferred to the tertiary centers. Regardless of trauma status, children with shock had an increased mortality rate compared with those without shock (all patients: 11.4% vs 2.6%), trauma patients (28.3% vs 1.2%), and nontrauma patients (10.5% vs 2.8%). Early shock reversal was associated with reduced mortality (5.06% vs 16.37%) and functional morbidity (1.56% vs 4.11%) rates. Early use of PALS/APLS-recommended interventions was associated with reduced mortality (8.69% vs 15.01%) and functional morbidity (1.24% vs 4.23%) rates. After controlling for center, severity of illness, and trauma status, early reversal of shock and use of PALS/APLS-recommended interventions remained associated with reduced morbidity and mortality rates. CONCLUSIONS: Shock is common in children who are transferred for tertiary care. Pediatric shock recognition and resuscitation in the community hospital improves survival and functional outcome regardless of diagnostic category. The development of shock/trauma systems for children with and without trauma seems prudent.

The state of pediatric interfacility transport: Consensus of the Second National Pediatric and Neonatal Interfacility Transport Medicine Leadership Conference

Interfacility transport of pediatric and neonatal patients for advanced or specialty medical care is an integral part of our medical delivery system. Assessment of current services and planning for the future are imperative. As part of this process, the American Academy of Pediatrics and the Section on Transport Medicine held the second National Pediatric and Neonatal Transport Leadership Conference in Chicago in June 2000. Ninety-nine total participants, representing 25 states and 5 international locations, debated and discussed issues relevant to the developing specialty of pediatric transport medicine. These topics included: 1) the role of the medical director, 2) benchmarking of neonatal and pediatric transport programs, 3) clinical research, 4) accreditation, 5) team configuration, 6) economics of transport medicine in health care delivery, 7) justification of transport teams in institutions, and 8) international transport/extracurricular transport opportunities. Insights and conclusions from this meeting of transport leaders are presented in the consensus statement.

Pretransport Pediatric Risk of Mortality (prism) score underestimates the requirement for intensive care or major interventions during interhospital transport

Objective: To test the hypothesis that a pretransport Pediatric Risk of Mortality (PRISM) score underestimates the requirement for both intensive care and interventions during pediatric interhospital transport. Design: Prospective, descriptive study. Setting: All children were treated in a regional hospital and then transported to a pediatric tertiary care center by a pediatric critical care specialty team. Patients: Children (n = 156) with a median age of 1.3 yrs (range newborn to 18 yrs). Interventions: None related to the study. Measurements and Main Results: Two sets of Pediatric Risk of Mortality scores were calculated: one from data collected over the telephone at the time of the referral (Referral PRISM), and one from both the referring hospitals records and from data collected by the transport team on arrival at the referring hospital and before the team provided any intervention (Team PRISM). The admission area used on arrival at the tertiary care center (intensive care unit [ICU] vs. non‐ICU) and the number of major clinical interventions performed by both the referring hospital staff and the transport team were recorded. The Therapeutic Intervention Scoring System was used to assess the cumulative level of medical care provided up to 8 hrs after admission to the pediatric tertiary care hospital. No patient died during transport. The overall inhospital mortality rate was 5.1%. Median Therapeutic Intervention Scoring System scores were higher for patients admitted to the ICU (16 vs. 4, p < .001). Whereas median PRISM scores were significantly higher in those children admitted to the ICU (4 vs. 0, p < .001), 58 (75%) of 77 ICU admissions had a Team PRISM score of ≤10. Fortyfour (71%) of 62 children who required at least one major intervention at some time during the transport process and 15 (63%) of 24 children who required at least one major intervention by the transport team had a Team PRISM score of ≤10. Referral PRISM scores underestimated Team PRISM scores. Conclusions: PRISM scores determined before interhospital transfer of pediatric patients underestimated the requirement for intensive care and the performance of major interventions in the pretransport setting. Many patients with low PRISM scores required intensive care on admission to the receiving hospital and major interventions during the transport process, and, therefore, were not at “low risk” for clinical deterioration. The PRISM score should not be used as a severity of illness measure or triage tool for pediatric interhospital transport. (Crit Care Med 1994; 22:101‐107)

Updated American College of Critical Care Medicine-Pediatric Advanced Life Support guidelines for management of pediatric and neonatal septic shock: relevance to the emergency care clinician.

Shock is a major preventable cause of morbidity and mortality in children referred to emergency care. The recently updated American College of Critical Care Medicine guidelines for the management of newborns and children with septic shock emphasize the role of emergency care in improving survival and functional outcomes. Implementation of these guidelines of stepwise use of fluids, antibiotics, and, if necessary, inotropes within the first hour of admission to the emergency department can reduce mortality and neurological morbidity risks 2-fold. Therapies should be goal directed to maintain age-specific threshold heart rates and blood pressure as well as a capillary refill of less than 3 seconds or 2 seconds or less. Inotropes should be delivered through peripheral intravenous or intraosseous access when central access is unavailable because delay in inotrope delivery can greatly increase mortality risks. Emergency care systems should be organized to facilitate recognition, triage, and treatment of shock in the first hour. Emergency departments should be stocked with ready access to antibiotics, fluids, and inotrope infusions, and clinicians should be trained in the delivery of goal-directed fluid, antibiotics, and inotrope therapies in the first hour of resuscitation. For newborns, in addition to fluids, antibiotics, and inotropes, a prostaglandin infusion should be available within 10 minutes if duct-dependent congenital heart disease is a possibility.

New pigtail catheter for pleural drainage in pediatric patients.

The conventional method of pleural drainage is tube thoracotomy, accomplished by chest wall dissection and blunt puncture. While this method is successful, it is relatively traumatic. We have designed a pigtail catheter which may be inserted into the pleural space by a modified Seldinger technique. This 8.5-Fr polyurethane catheter has six side ports inside its circular distal end. An airtight plastic bag is attached to the insertion needle to confirm pleural placement. Nineteen catheters were inserted in 16 neonates and small children with either pneumothorax or pneumomediastinum. No complications were noted. All but one pneumothorax was successfully evacuated; however, the pneumomediastinum reaccumulated. Insertion proved to be safe, simple, and atraumatic. This pigtail pleural drainage catheter provides an alternative to standard tube thoracotomy.

Variables predicting the need for a pediatric critical care transport team.

To determine when a pediatric critical care transport team is required to transport a patient to a referral center, this cross-sectional study evaluated 369 consecutive pediatric transports by stepwise multiple logistic regression analysis of six variables: age, vital signs, seizure activity, current endotracheal intubation, respiratory distress, and respiratory diagnosis.Models were developed for three outcome variables: 1) Major procedures were required in 8.9% of cases. The predicted probability of needing a major procedure was increased for intubated patients (probability of 12.9%), patients <1 year of age with unstable vital signs (12.9%), and patients meeting both these criteria (23.2%). 2) A posttransport assessment of need for a physician on the team was positive in 43% of cases. The probability of needing a physician was increased for intubated patients (probability of 68.8%), patients <1 year of age with unstable vital signs (58.7%), and patients meeting both these criteria (79.9%). 3) Category 1 drugs, ie, medications requiring ICU monitoring, were used in 19% of transports. The probability of this occurring was increased for intubated patients with stable vital signs (probability of 24.7%) and for intubated patients with unstable vital signs (41.4%). None of the other pretransport variables, alone or in pairs, was a significant predictor of any of the three outcome variables.The data indicate that intubation, age, and vital sign status can be used in predicting whether a transport team is needed.

Interfacility Transport Shock Index Is Associated With Decreased Survival in Children

Background Shock index, the ratio of heart rate to systolic blood pressure that changes with age, is associated with mortality in adults after trauma and in children with sepsis. We assessed the utility of shock index to predict sepsis diagnosis and survival in children requiring interfacility transport to a tertiary care center. Methods We studied children aged 1 month to 21 years who had at least 2 sets of vital signs recorded during interfacility transport to the Children’s Hospital of Pittsburgh by our critical care transport team. Subjects were divided into 4 age groups: group 1 (<1 year), group 2 (1–3 years), group 3 (4–11 years), and group 4 (≥12 years). Children were also grouped into sepsis or nonsepsis group based on the International Classification of Diseases, Ninth Revision categories. Primary outcome was survival to hospital discharge. Results Of 3519 children studied, 493 (14%) had sepsis. Initial shock index decreased with increasing age: group 1, 1.45 ± 0.42 (mean ± SD); group 2, 1.35 ± 0.32; group 3, 1.20 ± 0.34; and group 4, 1.00 ± 0.32 (P < 0.001). Initial shock index was increased in children with sepsis versus those with no sepsis overall and in all age groups (all P < 0.05). Initial shock index showed a trend for association with survival in univariate analysis (P = 0.05) but was not associated with survival in a multivariable logistic regression. Highest quartile of shock index was associated with need for intensive care unit admission posttransport. Conclusions Increased shock index in children requiring intrafacility transport was associated with hospital discharge diagnosis of sepsis but not hospital survival.