Richard Charles Hoying

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Featured researches published by Richard Charles Hoying.

Tetrahedron Letters | 1989

An enantioselective synthesis of loracarbef (LY163892/KT3777)

Christina Bodurow; B. D. Boyer; John Brennan; C. A. Bunnell; J. E. Burks; Michael A. Carr; Christopher W. Doecke; T. M. Eckrich; Jack W. Fisher; John P. Gardner; B. J. Graves; P. Hines; Richard Charles Hoying; Billy Grinnell Jackson; Michael Dean Kinnick; C. D. Kochert; J. S. Lewis; W. D. Luke; Larry L. Moore; J. M. Jun. Morin; R. L. Nist; D. E. Prather; D. L. Sparks; William Charles Vladuchick

Abstract An enantioselective synthesis of the new, orally absorbable, totally synthetic β-lactam antibiotic, loracarbef (LY163892/KT3777) is described.

Tetrahedron Letters | 1993

Cleavage of chiral 4-phenyl-2-oxalidinones with TMSI: Application to the synthesis of carbacephems

Jack W. Fisher; James M. Dunigan; Lowell D. Hatfield; Richard Charles Hoying; James E. Ray; Kristina Lynn Thomas

Abstract A new technique for cleaving N-substituted 4-phenyl-2-oxazolidinones is described. Thus reaction of a 7-[4-phenyl-2-oxazolidinone]-carbacephem with TMSI and HMDS in acetonitrile, followed by DABCO, then aqueous hydrochloric acid gives the carbacephem nucleus, carbon dioxide, and acetophenone. This method allows a more versatile use of 4-phenyl-2-oxazolidinone as a chiral auxiliary and N-protective group in the synthesis of carbacephems.

Archive | 2006

6-substituted 2,3,4,5-tetrahydro-1h-benzo[d]azepines as 5-ht2c receptor agonists

John Gordon Allen; Karin Briner; Anne Marie Camp; Manuel Javier Cases-Thomas; Richard Charles Hoying; Maria Angeles Martinez-Grau; Michael Philip Mazanetz; Natalia Pokrovskaia; Richard Edmund Rathmell; Roger Ryan Rothhaar; Selma Sapmaz; Andrew Caerwyn Williams

Archive | 1990

DMF solvates of a β-lactam antibiotic

Thomas Michael Eckrich; Richard Charles Hoying

Heterocycles | 2001

Synthesis of 2-Phenyloxazole Derivatives Containing Amino Acids as Insulin Sensitivity Enhancers for Treatment of Type II Diabetes

Margaret M. Faul; Leonard L. Winneroski; Jeremy Schulenburg York; Matt R. Reinhard; Richard Charles Hoying; William Harlan Gritton; Samuel J. Dominianni

Archive | 1989