Richard E. Hoover

Trabecular and Retrocorneal Proliferation of Melanocytes and Secondary Glaucoma

A 59-year-old woman with no evidence of glaucoma developed secondary open-angle glaucoma after an intracapsular cataract extraction complicated by vitreous and iris incarceration. Histopathologic and scanning and electron microscopic studies of the enucleated eye 22 years later revealed extensive proliferation of iris melanocytes across the trabecular meshwork and posterior surface of the cornea. Proliferation of iris stromal melanocytes over the trabecular meshwork may have caused secondary open-angle glaucoma.

Iododerma of the Conjunctiva and Skin

A 60-year-old white woman developed lesions of the conjunctiva and skin consistent with iododerma. Excision and examination of one of the skin lesions and the conjunctival lesion disclosed pseudoepitheliomatous hyperplasia associated with acute and chronic inflammation. The remaining lesions disappeared with cessation of iodide. We review the clinical and histopathologic features of the halodermas and discuss the ocular manifestations of iodide hypersensitivity. Recognition may require exceedingly careful testing, but such care is necessary because fatal cases of iododerma have occurred.