Richard H. Follis

Thyroiditis resulting from administration of excess iodine to hamsters with hyperplastic goiters.

Summary Administration of large amounts of iodine to hamsters which have hyperplastic goiters produced by an iodine-deficient diet or by a goitrogen results in a morphologic response which is different from that encountered when iodine is given in physiological amounts. An acute inflammatory reaction and a diminution of the accumulation of colloid are found, neither of which has been observed in animals treated with smaller amounts of iodine.

Experimental lathyrism in the rat; nature of defect in epiphysial cartilage.

Summary The hydroxyproline, and hence collagen, content of epiphysial cartilage from rats treated with AAN is not reduced from the normal. Homogenized fractions of cartilage from rats which have received AAN are virtually devoid of collagen fibrils when examined with electron microscope. The defect appears to be a failure of the tropocollagen molecule to form collagen fibers.

A kwashiorkor-like syndrome observed in monkeys fed maize.

Summary Growing monkeys have been maintained up to 41 weeks on a diet of maize. Animals exhibit growth failure, loss of weight, weakness, apathy, edema with hypoalbuminemia and fat accumulation in the liver, which begins periportally and then spreads to involve the entire lobule. This syndrome appears to have many of the characteristics of kwashiorkor in children.

Experimental Colloid Goiter in the Hamster.

Summary Extreme hyperplasia of the thyroid gland has been produced in hamsters by placing them on iodine-deficient diets. When iodine is administered large amounts of colloid accumulate in the thyroid follicles, giving rise to the morphological picture of diffuse colloid goiter. Marines concept of the pathogenesis of colloid goiter: normal gland → hyperplasia → (iodine treatment) → colloid goiter, appears to have been proved under laboratory conditions, in the hamster at least.

Iodine-Induced Submandibular Sialadenitis in the Hamster

Summary Administration of large amounts of potassium iodide to the hamster leads to an inflammatory reaction in the submandibular glands, but not in the parotid or sublingual structures. The primary site of damage is the distal duct system. Such selective damage by this agent may be related to the greater concentrating ability of iodine by the submandibular glands in contrast to the parotids and sublinguals.

Dehydrogenase Activity of Rat Epiphyseal Cartilage.

Summary Utilizing the tetrazolium technic, intracellular dehydrogenase activity has been localized in epiphyseal cartilage cells. The most favorabe substrates appear to be succinate. isocitrate, citrate, lactate and malate.

Iodinated protein patterns in thyroids from normal and iodine deficient hamsters.

Summary The patterns of soluble iodinated proteins from the thyroid glands of iodine deficient hamsters differ from the normal in that a component other than thyroglobulin is found in increasing amounts as the deficient state develops.

Psammoma Bodies Associated with Experimental Thyroid Hyperplasia in the Rat

Summary Psammoma bodies have been noted in the hyperplastic thyroid glands of rats which were fed iodine-deficient diets. Such bodies have not been observed in hamsters, mice, and monkeys maintained on similar diets.

Spontaneous hemorrhage induced by administration of aminoacetonitrile and papain or anticoagulants to rats.

Summary When appropriate amounts of the lathyrogenic agent, AAN, are administered together with papain or the anti-coagulants, heparin or polyglucose sulfate, widespread spontaneous subperiosteal hemorrhages are seen. These do not occur when these materials are administered by themselves. The possible underlying mechanisms of this change are discussed.

PANEL DISCUSSION ON PROPER NUTRITION FOR THE OLDER AGE GROUP

Moderator: CLIVE M. MCCAY, PH.D., Professor of Nutrition, Cornell University, Ithaca, N.Y. Panelists: RICHARD H. FOLLIS, JR., M.D., V. A. Central Laboratory for Anatomical Pathology and Research, Armed Forces Institute of Pathology, Washington, D.C. NORMAN JOLLIFFE, M.D., Director, Bureau of Nutrition, Department of Health, New York, N. Y. WILLIAM B. KOUNTZ, M.D., Assistant Professor of Clinical Medicine, Washington University, St. Louis, Missouri. S. O. WAIFE, M.D., Editor-in-Chief, The American Journal of Clinical Nutrition, New York, N. Y.