Richard H. Kramss

The synthesis and structure activity relationships of enantiomerically pure hydroxylated oxotremorine derivatives

Abstract The synthesis and radioligand binding data of optically active hydroxylated oxotremorine derivatives are described. These are significant pharmacological differences between the enantiomers, most notably at the 3- and 4-position of the pyrrolidinone ring. In addition, there appears to be one side of the pyrrolidinone ring that accommodates substituents better than the other (facial selectivity).